Publications by authors named "Michael D Shultz"

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Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
Christopher G Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M Gardinier, Michael D Shultz

ACS Med Chem Lett· December 2023

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Evolution of Novartis' Small Molecule Screening Deck Design.
Ansgar Schuffenhauer, Nadine Schneider, Samuel Hintermann, Douglas Auld, Jutta Blank, Michael D Shultz

J Med Chem· December 2020

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
Matthew J LaMarche, Michael Acker, Andreea Argintaru, Daniel Bauer, Julie Boisclair, Michael D Shultz

J Med Chem· November 2020

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Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Jeffrey T Bagdanoff, Zhouliang Chen, Michael Acker, Ying-Nan Chen, Homan Chan, Michael D Shultz

J Med Chem· April 2019

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Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Patrick Sarver, Michael Acker, Jeffrey T Bagdanoff, Zhouliang Chen, Ying-Nan Chen, Michael D Shultz

J Med Chem· April 2019

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Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs.
Michael D Shultz

J Med Chem· February 2019

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Dual Allosteric Inhibition of SHP2 Phosphatase.
Michelle Fodor, Edmund Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Michael David Shultz

ACS Chem Biol· March 2018

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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Ying Huang, Jeff Zhang, Zhengtian Yu, Hailong Zhang, Youzhen Wang, Michael D Shultz

J Med Chem· March 2017

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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Andreas Lingel, Martin Sendzik, Ying Huang, Michael D Shultz, John Cantwell

J Med Chem· January 2017

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Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis.
Brian A Shapiro, Ngoc T Vu, Michael D Shultz, Jacqueline C Shultz, Jennifer A Mietla

J Biol Chem· October 2016

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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Jorge Garcia Fortanet, Christine Hiu-Tung Chen, Ying-Nan P Chen, Zhouliang Chen, Zhan Deng, Michael D Shultz

J Med Chem· September 2016

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan, Peter Fekkes, Jorge Garcia-Fortanet, Michael D Shultz

Nature· July 2016

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Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis.
Ngoc T Vu, Margaret A Park, Michael D Shultz, Gamze B Bulut, Amy C Ladd

Cancer Res· May 2016

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Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol - Optimization for Heating and Broad Stability in Biomedical Applications.
Stanley E Gilliland, Everett E Carpenter, Michael D Shultz

Nanobiomedicine (Rij)· January 2014

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Improving the plausibility of success with inefficient metrics.
Michael D Shultz

ACS Med Chem Lett· January 2014

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Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters.
Michael D Shultz

Bioorg Med Chem Lett· November 2013

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The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations.
Michael D Shultz

Bioorg Med Chem Lett· November 2013

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Metallofullerenes: a new class of MRI agents and more?
Panos P Fatouros, Michael D Shultz

Nanomedicine (Lond)· November 2013

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Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.
Michael D Shultz, Dyuti Majumdar, Donovan N Chin, Pascal D Fortin, Yun Feng

J Med Chem· September 2013

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Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
Michael D Shultz, Atwood K Cheung, Christina A Kirby, Brant Firestone, Jianmei Fan

J Med Chem· August 2013

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Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.
Jennifer A Mietla, Dayanjan S Wijesinghe, L Alexis Hoeferlin, Michael D Shultz, Ramesh Natarajan

J Lipid Res· July 2013

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hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.
Ngoc T Vu, Margaret A Park, Jacqueline C Shultz, Rachel W Goehe, L Alexis Hoeferlin, Michael D Shultz

J Biol Chem· March 2013

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Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.
John D Wilson, William C Broaddus, Harry C Dorn, Panos P Fatouros, Charles E Chalfant, Michael D Shultz

Bioconjug Chem· September 2012

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Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).
Andreas Fredenhagen, Matthias Kittelmann, Lukas Oberer, Anton Kuhn, Jürgen Kühnöl, Michael D Shultz

Drug Metab Dispos· May 2012

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The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.
Jacqueline C Shultz, Ngoc Vu, Michael D Shultz, Mba-Uzoma U Mba, Brian A Shapiro

Mol Cancer Res· May 2012

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