Publications by authors named "Michael J Root"

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Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env.
Hannah M Schapiro, Mukta D Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Michael J Root

PLoS Pathog· May 2022

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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.
Shiyu Zhang, Andrew P Holmes, Alexej Dick, Adel A Rashad, Lucía Enríquez Rodríguez, Michael J Root

Retrovirology· October 2021

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Characterization of resistance to a potent D-peptide HIV entry inhibitor.
Amanda R Smith, Matthew T Weinstock, Amanda E Siglin, Frank G Whitby, J Nicholas Francis, Michael J Root

Retrovirology· October 2019

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Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors.
Koree W Ahn, Michael J Root

J Biol Chem· October 2017

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Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity.
Maarten Danial, Angela N Stauffer, Frederik R Wurm, Michael J Root, Harm-Anton Klok

Bioconjug Chem· March 2017

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Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
Mukta D Khasnis, Konstantine Halkidis, Anshul Bhardwaj, Michael J Root

PLoS Pathog· December 2016

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Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.
George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Michael J Root

PLoS Pathog· November 2016

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Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors.
Maarten Danial, Michael J Root, Harm-Anton Klok

Biomacromolecules· May 2012

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Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin α5.
Ruth A Pumroy, Jonathan D Nardozzi, Darren J Hart, Michael J Root, Gino Cingolani

J Biol Chem· January 2012

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Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance.
Brett D Welch, J Nicholas Francis, Joseph S Redman, Suparna Paul, Matthew T Weinstock, Michael J Root

J Virol· November 2010

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Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding.
Kristen M Kahle, H Kirby Steger, Michael J Root

PLoS Pathog· November 2009

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Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil.
Kelly Champagne, Akira Shishido, Michael J Root

J Biol Chem· February 2009

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Implantable cardiac rhythm device batteries.
Michael J Root

J Cardiovasc Transl Res· December 2008

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Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain.
Sharad P Adekar, Tsuyoshi Takahashi, R Mark Jones, Fetweh H Al-Saleem, Denise M Ancharski, Michael J Root

PLoS One· August 2008

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Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins.
Sharad P Adekar, R Mark Jones, M D Elias, Fetweh H Al-Saleem, Michael J Root

J Immunol Methods· April 2008

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A human monoclonal antibody that binds serotype A botulinum neurotoxin.
Sharad P Adekar, R Mark Jones, M D Elias, Fetweh H Al-Saleem, Michael J Root

Hybridoma (Larchmt)· February 2008

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C34, a membrane fusion inhibitor, blocks HIV infection of langerhans cells and viral transmission to T cells.
Makoto Sugaya, Oliver Hartley, Michael J Root, Andrew Blauvelt

J Invest Dermatol· June 2007

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Kinetic dependence to HIV-1 entry inhibition.
H Kirby Steger, Michael J Root

J Biol Chem· September 2006

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HIV-1 gp41 as a target for viral entry inhibition.
Michael J Root, H Kirby Steger

Curr Pharm Des· June 2004

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Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein.
Michael J Root, Dean H Hamer

Proc Natl Acad Sci U S A· April 2003

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Clinical pharmacology of human growth hormone and its secretagogues.
Allen W Root, Michael J Root

Curr Drug Targets Immune Endocr Metabol Disord· April 2002

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