Publications by authors named "Michael J Topper"

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MYC plus class IIa HDAC inhibition drives mitochondrial dysfunction in non-small cell lung cancer.
Jina Park, Ying-Yu Chen, Jennie J Cao, Julia An, Ray-Whay Chiu Yen, Michael J Topper

Cell Rep· June 2025

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ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.
Lora Stojanovic, Rachel Abbotts, Kaushelendra Tripathi, Collin M Coon, Saranya Rajendran, Michael J Topper

Cancer Res· April 2025

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Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.
Michael J Topper, Joseph W Guarnieri, Jeffrey A Haltom, Amy Chadburn, Henry Cope

Proc Natl Acad Sci U S A· December 2024

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Bone marrow microenvironment signatures associate with patient survival after guadecitabine and atezolizumab therapy in HMA-resistant MDS.
H Josh Jang, Guillermo Urrutia, Andreas Due Orskov, Hyeon Jin Kim, Seth A Nelson, Michael J Topper

bioRxiv· November 2024

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ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer.
Lora Stojanovic, Rachel Abbotts, Kaushlendra Tripathi, Collin M Coon, Saranya Rajendran, Michael J Topper

bioRxiv· October 2024

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Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling.
Alison A Chomiak, Rochelle L Tiedemann, Yanqing Liu, Xiangqian Kong, Ying Cui, Michael J Topper

Sci Adv· March 2024

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Derivation of CD8 T cell infiltration potentiators in non-small-cell lung cancer through tumor microenvironment analysis.
Michael J Topper, Valsamo Anagnostou, Kristen A Marrone, Victor E Velculescu, Peter A Jones

iScience· July 2023

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A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
H Josh Jang, Galen Hostetter, Alexander W Macfarlane, Zachary Madaj, Eric A Ross, Michael J Topper

Clin Cancer Res· June 2023

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A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.
David A Jamison, S Anand Narayanan, Nídia S Trovão, Joseph W Guarnieri, Michael J Topper

Eur J Hum Genet· August 2022

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Activating STING1-dependent immune signaling in mutant and wild-type acute myeloid leukemia.
Aksinija A Kogan, Michael J Topper, Anna J Dellomo, Lora Stojanovic, Lena J McLaughlin

Proc Natl Acad Sci U S A· July 2022

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Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a -Dependent Manner.
James I McDonald, Noor Diab, Elisa Arthofer, Melissa Hadley, Tomas Kanholm, Michael J Topper

Cancer Res· October 2021

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Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
Lena J McLaughlin, Lora Stojanovic, Aksinija A Kogan, Julia L Rutherford, Eun Yong Choi, Michael J Topper

Proc Natl Acad Sci U S A· July 2020

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Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
Zhihao Lu, Jianling Zou, Shuang Li, Michael J Topper, Yong Tao

Nature· March 2020

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The emerging role of epigenetic therapeutics in immuno-oncology.
Michael J Topper, Michelle Vaz, Kristen A Marrone, Julie R Brahmer, Stephen B Baylin

Nat Rev Clin Oncol· February 2020

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DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
Rachel Abbotts, Michael J Topper, Christopher Biondi, Daniel Fontaine, Reena Goswami

Proc Natl Acad Sci U S A· November 2019

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Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.
Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M Brown, Yi Cai, Michael J Topper

Cancer Cell· April 2019

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Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic.
Meredith L Stone, Katherine B Chiappinelli, Huili Li, Lauren M Murphy, Meghan E Travers, Michael J Topper

Proc Natl Acad Sci U S A· September 2018

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Reflections and inspirations: my year as your AVMA president.
Michael J Topper

J Am Vet Med Assoc· July 2018

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Building strong and sustainable partnerships to protect, promote, and advance your interests.
Michael J Topper

J Am Vet Med Assoc· May 2018

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Cultivating our next generation of leaders.
Michael J Topper

J Am Vet Med Assoc· February 2018

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Resolve to volunteer and give back to the profession.
Michael J Topper

J Am Vet Med Assoc· January 2018

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Enhancing our commitment to wellness, diversity, and inclusion in the veterinary profession.
Michael J Topper

J Am Vet Med Assoc· December 2017

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Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.
Meredith L Stone, Katherine B Chiappinelli, Huili Li, Lauren M Murphy, Meghan E Travers, Michael J Topper

Proc Natl Acad Sci U S A· December 2017

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What do pets in New Mexico have to do with one health?
Michael J Topper

J Am Vet Med Assoc· November 2017

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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
Michael J Topper, Michelle Vaz, Katherine B Chiappinelli, Christina E DeStefano Shields, Noushin Niknafs

Cell· November 2017

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