Publications by authors named "Michael L McCaleb"

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A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy.
Sean J Barbour, Michelle A Hladunewich, Michael L McCaleb, Richard Robson, Terrance D Barrett

Kidney Int· December 2025

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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen.
Michael L McCaleb, Steven G Hughes, Tamar R Grossman, Ashley Frazer-Abel, Bill Jung

Immunobiology· March 2025

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TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis.
Tomas Ganz, Elizabeta Nemeth, Stefano Rivella, Paul Goldberg, Andrew R Dibble, Michael L McCaleb

Adv Ther· April 2023

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Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide.
Tamar R Grossman, Michele Carrer, Lijiang Shen, Robert B Johnson, Lisa A Hettrick, Michael L McCaleb

Mol Vis· April 2018

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IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.
Shih-Yen Weng, Xiaoyu Wang, Santosh Vijayan, Yilang Tang, Yong Ook Kim, Michael L McCaleb

EBioMedicine· March 2018

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Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in mice.
Tamar R Grossman, Lisa A Hettrick, Robert B Johnson, Gene Hung, Raechel Peralta, Michael L McCaleb

Immunobiology· June 2016

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In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.
Gaetan Billioud, Robert L Kruse, Melissa Carrillo, Christina Whitten-Bauer, Dacao Gao, Michael L McCaleb

J Hepatol· April 2016

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Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.
Susan F Murray, Ali Jazayeri, Michael T Matthes, Douglas Yasumura, Haidong Yang, Michael L McCaleb

Invest Ophthalmol Vis Sci· October 2015

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Clinical Trial Design for Alpha-1 Antitrypsin Deficiency: A Model for Rare Diseases.
Adam Wanner, Stephen C Groft, J Russell Teagarden, Jeffrey Krischer, Barry R Davis, Michael L McCaleb

Chronic Obstr Pulm Dis· April 2015

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Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease.
Shuling Guo, Sheri L Booten, Andrew Watt, Luis Alvarado, Susan M Freier, Michael L McCaleb

Rare Dis· July 2014

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Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.
Xing Xian Yu, Lynnetta M Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P Monia, Michael L McCaleb

PLoS One· February 2014

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Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.
Shuling Guo, Sheri L Booten, Mariam Aghajan, Gene Hung, Chenguang Zhao, Michael L McCaleb

J Clin Invest· January 2014

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