Publications by authors named "Michael Lenardo"

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The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer.
Chen Xiang, Ann Y Park, Sarah E Weber, Michael J Lenardo, Ahmet Ozen

Nat Immunol· September 2025

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CARD11 signaling regulates CD8 T cell tumoricidal function.
Yu Hu, Qifan Zhao, Yingquan Qin, Song Mei, Benyu Wang, Michael J Lenardo

Nat Immunol· July 2025

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The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology.
Alison M Pagalilauan, Elif Everest, Suzanna Rachimi, Daniel S Reich, Alex D Waldman, Michael J Lenardo

Front Neurol· March 2025

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The patient experience of CHAPLE disease: results from interviews conducted as part of a clinical trial for an ultra-rare condition.
Leighann Litcher-Kelly, Ahmet Ozen, Sarah Ollis, Hagit Baris Feldman, Andrew Yaworsky, Michael J Lenardo

Orphanet J Rare Dis· February 2025

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pH-dependent dissociation from CTLA-4 in early endosomes improves both safety and antitumor activity of anti-CTLA-4 antibodies.
Meiyu Zhang, Jinmei Li, Kepeng Yan, Haoyue Zhou, Song Mei, Michael J Lenardo

Proc Natl Acad Sci U S A· February 2025

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AMBRA1 controls the translation of immune-specific genes in T lymphocytes.
Simone Gottlieb, Wanjing Shang, Deji Ye, Satoshi Kubo, Ping Du Jiang, Michael J Lenardo

Proc Natl Acad Sci U S A· October 2024

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Germline mutations in a G protein identify signaling cross-talk in T cells.
Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Michael J Lenardo

Science· September 2024

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Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments.
Leighann Litcher-Kelly, Ahmet Ozen, Sarah Ollis, Hagit Baris Feldman, Andrew Yaworsky, Michael J Lenardo

Orphanet J Rare Dis· August 2024

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Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Ann Y Park, Michael Leney-Greene, Matthew Lynberg, Justin Q Gabrielski, Xijin Xu, Michael J Lenardo

Nat Immunol· April 2024

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The Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis cohort population structure and disease etiology.
Alison M Pagalilauan, Elif Everest, Suzanna Rachimi, Daniel Reich, Alex D Waldman, Michael J Lenardo

medRxiv· April 2024

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The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study.
Alex D Waldman, Cecilia Catania, Marco Pisa, Mark Jenkinson, Michael J Lenardo

Acta Neuropathol· March 2024

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GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Ann Y Park, Michael Leney-Greene, Matthew Lynberg, Justin Q Gabrielski, Xijin Xu, Michael J Lenardo

Nat Immunol· February 2024

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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ahmet Ozen, Voranush Chongsrisawat, Asena Pinar Sefer, Burcu Kolukisa, Jessica J Jalbert, Michael J Lenardo

Lancet· February 2024

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Interim analysis: Open-label extension study of leniolisib for patients with APDS.
V Koneti Rao, Elaine Kulm, Anna Šedivá, Alessandro Plebani, Catharina Schuetz, Michael J Lenardo

J Allergy Clin Immunol· January 2024

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Adult-onset neurodegeneration in XMEN disease.
Daniel Benavides, Anusha Ebrahim, Juan C Ravell, Michael Lenardo, William A Gahl

J Neuroimmunol· January 2024

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Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards.
Holm H Uhlig, Claire Booth, Judy Cho, Marla Dubinsky, Anne M Griffiths, Michael J Lenardo

Nat Rev Gastroenterol Hepatol· December 2023

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Protein-Losing Enteropathy. Reply.
Ahmet Ozen, Michael J Lenardo

N Engl J Med· November 2023

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Protein-Losing Enteropathy.
Ahmet Ozen, Michael J Lenardo

N Engl J Med· August 2023

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A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome.
V Koneti Rao, Sharon Webster, Anna Šedivá, Alessandro Plebani, Catharina Schuetz, Michael J Lenardo

Blood· March 2023

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Death receptor 5 rises to the occasion.
Lixin Zheng, Yikun Yao, Michael J Lenardo

Cell Res· March 2023

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Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease.
Jian Li, Lisen Lu, Kyle Binder, Jian Xiong, Lilin Ye, Michael J Lenardo

Sci Adv· March 2023

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HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions.
Sarah Cook, Michael J Lenardo, Alexandra F Freeman

J Clin Immunol· November 2022

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ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA.
Ersilia Varone, Alexander Chernorudskiy, Alessandro Cherubini, Angela Cattaneo, Angela Bachi, Michael J Lenardo

Redox Biol· October 2022

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Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.
Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q Gabrielski, Lixin Zheng, Michael J Lenardo

Proc Natl Acad Sci U S A· August 2022

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Utility of targeted next generation sequencing for inborn errors of immunity at a tertiary care centre in North India.
Amit Rawat, Madhubala Sharma, Pandiarajan Vignesh, Ankur Kumar Jindal, Deepti Suri, Michael Lenardo

Sci Rep· June 2022

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