Publications by authors named "Michael Witty"

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Transformation of struvite from wastewater to a hydrogen fuel storage compound ammonia borane.
Nin Dingra, Michael Witty, Marie Celis, Narendra Boppana, Theppawut Ayudhya

Front Chem· November 2023

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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
Alasdair Smith, Richard J Wall, Stephen Patterson, Tim Rowan, Eva Rico Vidal, Michael J Witty

J Med Chem· April 2022

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Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Michael J Witty

PLoS Pathog· November 2020

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Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Michael J Witty

Antimicrob Agents Chemother· November 2018

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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Michael J Witty

Antimicrob Agents Chemother· September 2018

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The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty

PLoS Pathog· September 2018

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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Tsutomu Akama, Yong-Kang Zhang, Yvonne R Freund, Pamela Berry, Joanne Lee, Michael J Witty

Bioorg Med Chem Lett· January 2018

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Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold.
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, Michael Witty

J Med Chem· December 2017

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The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold.
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, Michael Witty

J Med Chem· August 2017

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Antimalarial efficacy of MMV390048, an inhibitor of phosphatidylinositol 4-kinase.
Tanya Paquet, Claire Le Manach, Diego González Cabrera, Yassir Younis, Philipp P Henrich, Michael J Witty

Sci Transl Med· April 2017

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Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
Claire Le Manach, Aloysius T Nchinda, Tanya Paquet, Diego Gonzàlez Cabrera, Yassir Younis, Michael J Witty

J Med Chem· November 2016

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A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
Claire Le Manach, Tanya Paquet, Christel Brunschwig, Mathew Njoroge, Ze Han, Michael J Witty

J Med Chem· November 2015

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Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines.
Diego Gonzàlez Cabrera, Frederic Douelle, Claire Le Manach, Ze Han, Tanya Paquet, Michael J Witty

J Med Chem· September 2015

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Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Yassir Younis, Dale Taylor, Michael J Witty

J Med Chem· November 2014

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Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives.
María J Chaparro, Jaume Vidal, Iñigo Angulo-Barturen, José M Bueno, Jeremy Burrows, Michael Witty

ACS Med Chem Lett· June 2014

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Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
Claire Le Manach, Diego Gonzàlez Cabrera, Frederic Douelle, Aloysius T Nchinda, Yassir Younis, Michael J Witty

J Med Chem· March 2014

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2,4-Diaminothienopyrimidines as orally active antimalarial agents.
Diego González Cabrera, Claire Le Manach, Frederic Douelle, Yassir Younis, Tzu-Shean Feng, Michael J Witty

J Med Chem· February 2014

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Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
Yassir Younis, Frederic Douelle, Diego González Cabrera, Claire Le Manach, Aloysius T Nchinda, Michael J Witty

J Med Chem· November 2013

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.
Claire Le Manach, Christian Scheurer, Sibylle Sax, Sarah Schleiferböck, Diego Gonzalez Cabrera, Michael J Witty

Malar J· November 2013

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Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries.
Yassir Younis, Leslie J Street, David Waterson, Michael J Witty, Kelly Chibale

J Med Chem· October 2013

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Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
Diego González Cabrera, Frederic Douelle, Yassir Younis, Tzu-Shean Feng, Claire Le Manach, Michael J Witty

J Med Chem· December 2012

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Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.
Tanya Paquet, Richard Gordon, David Waterson, Michael J Witty, Kelly Chibale

Future Med Chem· December 2012

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A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.
Félix Calderón, Jaume Vidal-Mas, Jeremy Burrows, Juan Carlos de la Rosa, María Belén Jiménez-Díaz, Michael Witty

ACS Med Chem Lett· May 2012

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3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
Yassir Younis, Frederic Douelle, Tzu-Shean Feng, Diego González Cabrera, Claire Le Manach, Michael J Witty

J Med Chem· April 2012

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Novel orally active antimalarial thiazoles.
Diego González Cabrera, Frederic Douelle, Tzu-Shean Feng, Aloysius T Nchinda, Yassir Younis, Michael J Witty

J Med Chem· November 2011

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