Publications by authors named "Michail Sitkovsky"

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Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors.
Ryan Murray, Md Raihan Chowdhury, Nuria Roxana Botticello-Romero, Kashvi Desai, Shanmuga Reddy Chilakapati, Michail V Sitkovsky

Nat Commun· November 2025

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Oxygen-carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced immunosuppression.
Katarina Halpin-Veszeleiova, Michael P Mallouh, Lucy M Williamson, Ashley C Apro, Nuria R Botticello-Romero, Michail V Sitkovsky

JCI Insight· March 2025

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Correction: A2B Adenosine Receptor Expression by Myeloid Cells is Proinflammatory in Murine Allergic-Airway Inflammation.
Bryan G Belikoff, Louis J Vaickus, Michail Sitkovsky, Daniel G Remick

J Immunol· February 2024

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Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors.
Thibault Colombani, Loek J Eggermont, Stephen M Hatfield, Zachary J Rogers, Mahboobeh Rezaeeyazdi, Michail V Sitkovsky

Adv Funct Mater· September 2021

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Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy.
Stephen M Hatfield, Michail V Sitkovsky

J Clin Invest· November 2020

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Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia.
Pierpaolo Correale, Massimo Caracciolo, Federico Bilotta, Marco Conte, Maria Cuzzola, Michail Sitkovsky

PLoS One· October 2020

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Sufficient numbers of anti-tumor T cells is a condition of maximal efficacy of anti-hypoxia-A2-adenosinergic drugs during cancer immunotherapy.
Michail V Sitkovsky

Curr Opin Pharmacol· August 2020

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Lessons from the A2A Adenosine Receptor Antagonist-Enabled Tumor Regression and Survival in Patients with Treatment-Refractory Renal Cell Cancer.
Michail V Sitkovsky

Cancer Discov· January 2020

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Mechanistic Justifications of Systemic Therapeutic Oxygenation of Tumors to Weaken the Hypoxia Inducible Factor 1α-Mediated Immunosuppression.
Stephen Hatfield, Katarina Veszeleiova, Joe Steingold, Jyothi Sethuraman, Michail Sitkovsky

Adv Exp Med Biol· August 2019

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A Adenosine Receptor Gene Deletion or Synthetic A Antagonist Liberate Tumor-Reactive CD8 T Cells from Tumor-Induced Immunosuppression.
Jorgen Kjaergaard, Stephen Hatfield, Graham Jones, Akio Ohta, Michail Sitkovsky

J Immunol· July 2018

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Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.
Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M Hatfield, Michail V Sitkovsky

PLoS One· December 2017

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Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.
Murillo Silva, Thao H Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Michail V Sitkovsky

Cell Rep· December 2017

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Fluorinated Adenosine A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.
Gengyang Yuan, Tanner C Jankins, Christopher G Patrick, Phaethon Philbrook, Olivia Sears, Michail Sitkovsky

Int J Med Chem· October 2017

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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
Almut Grenz, Jessica D Bauerle, Julee H Dalton, Douglas Ridyard, Alexander Badulak, Michail Sitkovsky

J Clin Invest· June 2017

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Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases.
Bruce N Cronstein, Michail Sitkovsky

Nat Rev Rheumatol· January 2017

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The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.
Robert K Abbott, Murillo Silva, Jasmine Labuda, Molly Thayer, Derek W Cain, Michail Sitkovsky

J Biol Chem· January 2017

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Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.
Robert K Abbott, Molly Thayer, Jasmine Labuda, Murillo Silva, Phaethon Philbrook, Michail Sitkovsky

J Immunol· November 2016

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A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.
Stephen M Hatfield, Michail Sitkovsky

Curr Opin Pharmacol· August 2016

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Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma.
Dashnamoorthy Ravi, Afshin Beheshti, Nasséra Abermil, Frank Passero, Jaya Sharma, Michail V Sitkovsky

Cancer Res· June 2016

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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.
Stephen M Hatfield, Michail Sitkovsky

Oncoimmunology· December 2015

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Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Taylor H Schreiber, Bryan Belikoff, Michail V Sitkovsky

Sci Transl Med· March 2015

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Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
Stephen M Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Bryan Belikoff, Taylor H Schreiber, Michail Sitkovsky

J Mol Med (Berl)· December 2014

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Postoperative hyperoxia (60%) worsens hepatic injury in mice.
Quirin Zangl, André Martignoni, Sharon H Jackson, Akio Ohta, Brenda Klaunberg, Michail Sitkovsky

Anesthesiology· December 2014

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Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists.
Michail V Sitkovsky, Stephen Hatfield, Robert Abbott, Bryan Belikoff, Dmitriy Lukashev

Cancer Immunol Res· July 2014

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Extracellular adenosine-mediated modulation of regulatory T cells.
Akio Ohta, Michail Sitkovsky

Front Immunol· July 2014

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