Publications by authors named "Stephen Hatfield"

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Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors.
Ryan Murray, Md Raihan Chowdhury, Nuria Roxana Botticello-Romero, Kashvi Desai, Shanmuga Reddy Chilakapati, Stephen M Hatfield

Nat Commun· November 2025

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Polymer oxidation: A strategy for the controlled degradation of injectable cryogels.
Alexandra Nukovic, Mohammad Hamrangsekachaee, Mahalakshmi Rajkumar, Gwyneth Wong, Emily R Tressler, Stephen M Hatfield

Mater Today Bio· June 2025

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Breaking barriers: Smart vaccine platforms for cancer immunomodulation.
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M Hatfield

Cancer Commun (Lond)· May 2025

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Oxygen-carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced immunosuppression.
Katarina Halpin-Veszeleiova, Michael P Mallouh, Lucy M Williamson, Ashley C Apro, Nuria R Botticello-Romero, Stephen M Hatfield

JCI Insight· March 2025

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Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients.
Katarina Halpin-Veszeleiova, Stephen M Hatfield

Physiology (Bethesda)· January 2022

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Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors.
Thibault Colombani, Loek J Eggermont, Stephen M Hatfield, Zachary J Rogers, Mahboobeh Rezaeeyazdi

Adv Funct Mater· September 2021

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Targeting Hypoxia-A2A Adenosinergic Immunosuppression of Antitumor T Cells During Cancer Immunotherapy.
Joseph M Steingold, Stephen M Hatfield

Front Immunol· May 2021

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Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy.
Stephen M Hatfield, Michail V Sitkovsky

J Clin Invest· November 2020

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Oxygenation and A2AR blockade to eliminate hypoxia/HIF-1α-adenosinergic immunosuppressive axis and improve cancer immunotherapy.
Katarina Halpin-Veszeleiova, Stephen M Hatfield

Curr Opin Pharmacol· August 2020

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Editorial overview: Cancer 2020 current mechanistic insights into the hypoxia-adenosine-A2A adenosinergic immunosuppressive axis in cancer immunotherapies.
Paul A Beavis, Stephen M Hatfield

Curr Opin Pharmacol· August 2020

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Mechanistic Justifications of Systemic Therapeutic Oxygenation of Tumors to Weaken the Hypoxia Inducible Factor 1α-Mediated Immunosuppression.
Stephen Hatfield, Katarina Veszeleiova, Joe Steingold, Jyothi Sethuraman, Michail Sitkovsky

Adv Exp Med Biol· August 2019

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Corrigendum: Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.
Claudia Sorrentino, Fokhrul Hossain, Paulo C Rodriguez, Rosa A Sierra, Antonio Pannuti, Stephen Hatfield

Front Immunol· May 2019

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A Adenosine Receptor Gene Deletion or Synthetic A Antagonist Liberate Tumor-Reactive CD8 T Cells from Tumor-Induced Immunosuppression.
Jorgen Kjaergaard, Stephen Hatfield, Graham Jones, Akio Ohta, Michail Sitkovsky

J Immunol· July 2018

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Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.
Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M Hatfield

PLoS One· December 2017

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Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.
Murillo Silva, Thao H Nguyen, Phaethon Philbrook, Matthew Chu, Olivia Sears, Stephen Hatfield

Cell Rep· December 2017

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Fluorinated Adenosine A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.
Gengyang Yuan, Tanner C Jankins, Christopher G Patrick, Phaethon Philbrook, Olivia Sears, Stephen Hatfield

Int J Med Chem· October 2017

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The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.
Robert K Abbott, Murillo Silva, Jasmine Labuda, Molly Thayer, Derek W Cain, Stephen Hatfield

J Biol Chem· January 2017

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Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.
Robert K Abbott, Molly Thayer, Jasmine Labuda, Murillo Silva, Phaethon Philbrook, Stephen Hatfield

J Immunol· November 2016

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A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.
Stephen M Hatfield, Michail Sitkovsky

Curr Opin Pharmacol· August 2016

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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.
Stephen M Hatfield, Michail Sitkovsky

Oncoimmunology· December 2015

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Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Taylor H Schreiber, Bryan Belikoff

Sci Transl Med· March 2015

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Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
Stephen M Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Bryan Belikoff, Taylor H Schreiber

J Mol Med (Berl)· December 2014

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Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists.
Michail V Sitkovsky, Stephen Hatfield, Robert Abbott, Bryan Belikoff, Dmitriy Lukashev

Cancer Immunol Res· July 2014

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Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
Rhiannon Thomas, Joslynn Lee, Vincent Chevalier, Sara Sadler, Kaisa Selesniemi, Stephen Hatfield

Bioorg Med Chem· December 2013

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Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model.
Peter Georgiev, Bryan G Belikoff, Stephen Hatfield, Akio Ohta, Michail V Sitkovsky

Eur J Immunol· March 2013

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