Publications by authors named "Michele Launay"

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Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
Scott H Watterson, Zili Xiao, Dharmpal S Dodd, David R Tortolani, Wayne Vaccaro, Michele Launay

J Med Chem· May 2010

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An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
Suzanne J Suchard, Dawn K Stetsko, Patricia M Davis, Stacey Skala, Dominique Potin, Michele Launay

J Immunol· April 2010

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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.
Dharmpal S Dodd, Steven Sheriff, ChiehYing J Chang, Dawn K Stetsko, Linda M Phillips, Michele Launay

Bioorg Med Chem Lett· April 2007

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Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
Dominique Potin, Michele Launay, Francoise Monatlik, Patrice Malabre, Maud Fabreguettes

J Med Chem· November 2006

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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Dominique Potin, Michele Launay, Eric Nicolai, Maud Fabreguette, Patrice Malabre

Bioorg Med Chem Lett· February 2005

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