Publications by authors named "Michelle Clements"

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A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis.
Edward C Parkinson, W John Watkins, Sarah Edkins, James E McLaren, Michelle N Clements

Sci Transl Med· November 2025

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B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Kristina Pentieva, Aoife Caffrey, Bethany Duffy, Mary Ward, Michelle Clements

Proc Nutr Soc· September 2025

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A Bayesian framework to evaluate noninferiority in randomized controlled trials of uncommon conditions.
Victoria R Cornelius, Jack Elkes, Ian R White, Rebecca M Turner, Michelle Clements

J Clin Epidemiol· September 2025

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Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus.
Joshua D Vardigan, Parul S Pall, Dillon S McDevitt, ChienJung Huang, Michelle K Clements

Pain· March 2025

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Humanized Na1.8 rats overcome cross-species potency shifts in developing novel Na1.8 inhibitors.
Dillon S McDevitt, Joshua D Vardigan, Xiaoping Zhou, Thomas W Rosahl, Heather Zhou, Michelle K Clements

Neurobiol Pain· March 2025

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Exploring different objectives in non-inferiority trials.
Conor D Tweed, Matteo Quartagno, Michelle N Clements, Rebecca M Turner, Andrew J Nunn

BMJ· June 2024

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2-Aminopyridines as Potent and Selective Na1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model.
Michael J Breslin, Jeffrey W Schubert, Deping Wang, Chienjung Huang, Michelle K Clements

ACS Med Chem Lett· June 2024

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Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial.
Neal Russell, Michelle N Clements, Kazi Shammin Azmery, Adrie Bekker, Julia Bielicki

EClinicalMedicine· March 2024

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Incidence, pathogens and antimicrobial resistance of blood and cerebrospinal fluid isolates from a tertiary neonatal unit in South Africa: A 10 year retrospective review.
Reenu Thomas, Claude Ondongo-Ezhet, Nini Motsoaledi, Mike Sharland, Michelle Clements

PLoS One· January 2024

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Association of dietary flavan-3-ol intakes with plasma phenyl-γ-valerolactones: analysis from the TUDA cohort of healthy older adults.
Donato Angelino, Aoife Caffrey, Helene McNulty, Chris Ir Gill, Pedro Mena, Michelle Clements

Am J Clin Nutr· August 2023

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Practical approaches to Bayesian sample size determination in non-inferiority trials with binary outcomes.
Rebecca M Turner, Michelle N Clements, Matteo Quartagno, Victoria Cornelius, Suzie Cro

Stat Med· April 2023

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A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status.
Michelle Clements, Maria Heffernan, Mary Ward, Leane Hoey, Leanne C Doherty

J Bone Miner Res· December 2022

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Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve.
Rebecca M Klein, Mark E Layton, Hillary Regan, Christopher P Regan, Yuxing Li, Michelle K Clements

Channels (Austin)· December 2022

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Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults.
Martina Rooney, Catherine F Hughes, J J Strain, Michelle Clements, Helene McNulty

J Hum Nutr Diet· August 2022

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Improving clinical trial interpretation with ACCEPT analyses.
Michelle N Clements, Ian R White, Andrew J Copas, Victoria Cornelius, Suzie Cro

NEJM Evid· August 2022

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Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial.
Louise F Hill, Michelle N Clements, Mark A Turner, Daniele Donà, Irja Lutsar

Lancet Child Adolesc Health· January 2022

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Effectiveness of a fortified drink in improving B vitamin biomarkers in older adults: a controlled intervention trial.
Maria Heffernan, Leanne C Doherty, Roberta Hack Mendes, Michelle Clarke, Stephanie Hodge, Michelle Clements

Nutr Metab (Lond)· December 2021

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Global antibiotic dosing strategies in hospitalised children: Characterising variation and implications for harmonisation of international guidelines.
Michelle N Clements, Neal Russell, Julia A Bielicki, Sally Ellis, Silke Gastine

PLoS One· October 2021

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Associations of atrophic gastritis and proton-pump inhibitor drug use with vitamin B-12 status, and the impact of fortified foods, in older adults.
Kirsty M Porter, Leane Hoey, Catherine F Hughes, Mary Ward, Michelle Clements

Am J Clin Nutr· October 2021

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Constructing a representative in-silico population for paediatric simulations: Application to HIV-positive African children.
Roeland E Wasmann, Elin M Svensson, A Sarah Walker, Michelle N Clements, Paolo Denti

Br J Clin Pharmacol· July 2021

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Discovery of Arylsulfonamide Na1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.
Anthony J Roecker, Mark E Layton, Joseph E Pero, Michael J Kelly, Thomas J Greshock, Michelle Clements

ACS Med Chem Lett· June 2021

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Na1.7 target modulation and efficacy can be measured in nonhuman primate assays.
Richard L Kraus, Fuqiang Zhao, Parul S Pall, Dan Zhou, Joshua D Vardigan, Michelle K Clements

Sci Transl Med· May 2021

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Variation in Target Attainment of Beta-Lactam Antibiotic Dosing Between International Pediatric Formularies.
Silke Gastine, Yingfen Hsia, Michelle Clements, Charlotte I S Barker, Julia Bielicki

Clin Pharmacol Ther· April 2021

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The DURATIONS randomised trial design: Estimation targets, analysis methods and operating characteristics.
Matteo Quartagno, James R Carpenter, A Sarah Walker, Michelle Clements, Mahesh Kb Parmar

Clin Trials· December 2020

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Nationwide Remapping of Infection in Rwanda Using Circulating Cathodic Antigen Rapid Test: Taking Steps toward Elimination.
Eugene Ruberanziza, Udo Wittmann, Aimable Mbituyumuremyi, Alphonse Mutabazi, Carl H Campbell, Michelle N Clements

Am J Trop Med Hyg· July 2020

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