Publications by authors named "Mike Randal"

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Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Alice Lee-Dutra, Danielle K Wiener, Kristen L Arienti, Jing Liu, Neelakandha Mani, Mike Randal

Bioorg Med Chem Lett· April 2010

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Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Michael K Ameriks, Frank U Axe, Scott D Bembenek, James P Edwards, Yin Gu, Mike Randal

Bioorg Med Chem Lett· November 2009

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Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
Wenjin Yang, Raymond V Fucini, Bruce T Fahr, Mike Randal, Kenneth E Lind

Biochemistry· June 2009

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Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
Wenjin Yang, Wanli Lu, Yafan Lu, Min Zhong, Jian Sun, Mike Randal

J Med Chem· February 2006

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Allosteric inhibition of protein tyrosine phosphatase 1B.
Christian Wiesmann, Kenneth J Barr, Jenny Kung, Jiang Zhu, Daniel A Erlanson, Mike Randal

Nat Struct Mol Biol· August 2004

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Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
Brian C Raimundo, Johan D Oslob, Andrew C Braisted, Jennifer Hyde, Robert S McDowell, Mike Randal

J Med Chem· June 2004

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Potent small-molecule binding to a dynamic hot spot on IL-2.
Christopher D Thanos, Mike Randal, James A Wells

J Am Chem Soc· December 2003

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Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2.
Jennifer Hyde, Andrew C Braisted, Mike Randal, Michelle R Arkin

Biochemistry· June 2003

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Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering.
Daniel A Erlanson, Robert S McDowell, Molly M He, Mike Randal, Robert L Simmons

J Am Chem Soc· May 2003

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Binding of small molecules to an adaptive protein-protein interface.
Michelle R Arkin, Mike Randal, Warren L DeLano, Jennifer Hyde, Tinh N Luong

Proc Natl Acad Sci U S A· February 2003

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