Publications by authors named "Miles D Houslay"

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DISC1-PML protein interaction for congenital CMV infection-induced cortical neural progenitor deficit: perturbance of host signaling via viral IE1.
Atsushi Saito, Stephanie Tankou, Kazuhiro Ishii, Makiko Sakao-Suzuki, Edwin C Oh, Miles D Houslay

bioRxiv· September 2025

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Withdrawal: RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells.
Martin J Lynch, George S Baillie, Ahmed Mohamed, Xiang Li, Charlotte Maisonneuve, Miles D Houslay

J Biol Chem· March 2025

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Activation of Phosphodiesterase 3A: New Hope for Cardioprotection.
Mario Chiong, Miles D Houslay, Sergio Lavandero

Circulation· December 2022

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Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.
Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Miles D Houslay

Mol Psychiatry· March 2022

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Correction for Bjørgo et al., "Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex".
Elisa Bjørgo, Silje A Solheim, Hilde Abrahamsen, George S Baillie, Kim M Brown, Miles D Houslay

Mol Cell Biol· February 2022

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Withdrawal: Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5.
Xiang Li, George S Baillie, Miles D Houslay

J Biol Chem· August 2020

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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Faisa Omar, Jane E Findlay, Gemma Carfray, Robert W Allcock, Zhong Jiang, Miles D Houslay

Proc Natl Acad Sci U S A· July 2019

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The Association of the Long Prostate Cancer Expressed PDE4D Transcripts to Poor Patient Outcome Depends on the Tumour's TMPRSS2-ERG Fusion Status.
Dianne van Strijp, Christiane de Witz, Birthe Heitkötter, Sebastian Huss, Martin Bögemann, Miles D Houslay

Prostate Cancer· June 2019

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A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.
Eirini Vagena, Jae Kyu Ryu, Bernat Baeza-Raja, Nicola M Walsh, Catriona Syme, Miles D Houslay

Transl Psychiatry· May 2019

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Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).
Dave J P Henderson, Miles D Houslay, Chris H Bangma, Ralf Hoffmann

Clin Sci (Lond)· January 2019

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DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness.
Elise L V Malavasi, Kyriakos D Economides, Ellen Grünewald, Paraskevi Makedonopoulou, Philippe Gautier, Miles D Houslay

Transl Psychiatry· September 2018

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The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.
Dianne van Strijp, Christiane de Witz, Pieter C Vos, Eveline den Biezen-Timmermans, Anne van Brussel, Miles D Houslay

Prostate Cancer· July 2018

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Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.
Marcia Alves de Inda, Dianne van Strijp, Eveline den Biezen-Timmermans, Anne van Brussel, Janneke Wrobel, Miles D Houslay

Eur Urol Focus· April 2018

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Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.
Motomasa Tanaka, Koko Ishizuka, Yoko Nekooki-Machida, Ryo Endo, Noriko Takashima, Miles D Houslay

J Clin Invest· April 2017

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Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.
Kirsty F Houslay, Frank Christian, Ruth MacLeod, David R Adams, Miles D Houslay

Biochem J· February 2017

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Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases.
René Böttcher, Kalyan Dulla, Dianne van Strijp, Natasja Dits, Esther I Verhoef, Miles D Houslay

Oncotarget· October 2016

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Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.
Robbert Havekes, Alan J Park, Jennifer C Tudor, Vincent G Luczak, Rolf T Hansen, Miles D Houslay

Elife· August 2016

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Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Robbert Havekes, Alan J Park, Rosa E Tolentino, Vibeke M Bruinenberg, Jennifer C Tudor, Miles D Houslay

J Neurosci· August 2016

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SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.
Stephanie Tankou, Kazuhiro Ishii, Christina Elliott, Krishna C Yalla, Jon P Day, Miles D Houslay

Mol Neuropsychiatry· May 2016

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Melanoma, Viagra, and PDE5 Inhibitors: Proliferation and Metastasis.
Miles D Houslay

Trends Cancer· April 2016

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p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.
Bernat Baeza-Raja, Benjamin D Sachs, Pingping Li, Frank Christian, Eirini Vagena, Miles D Houslay

Cell Rep· January 2016

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Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Christian Schachtrup, Jae Kyu Ryu, Könül Mammadzada, Abdullah S Khan, Peter M Carlton, Miles D Houslay

Nat Neurosci· August 2015

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The role of ventral striatal cAMP signaling in stress-induced behaviors.
Florian Plattner, Kanehiro Hayashi, Adan Hernández, David R Benavides, Tara C Tassin, Miles D Houslay

Nat Neurosci· August 2015

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Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Graeme B Bolger, Allan J Dunlop, Dong Meng, Jon P Day, Enno Klussmann, Miles D Houslay

Cell Signal· April 2015

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Editorial: Reflections on being 'founding' Editor-in-Chief of Cellular Signalling.
Miles D Houslay

Cell Signal· March 2015

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