Publications by authors named "Milton Packer"

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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
Milton Packer, Michael R Zile, Christopher M Kramer, Seth J Baum, Sheldon E Litwin, Venu Menon, Junbo Ge, Govinda J Weerakkody, Yang Ou, Mathijs C Bunck

N Engl J Med· January 2025

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Lessons for Cardiovascular Clinical Investigators: The Tumultuous 2,500-Year Journey of Physicians Who Ignited Our Fire.
Milton Packer

J Am Coll Cardiol· July 2024

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Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure.
Milton Packer, Stefan D Anker, Javed Butler, Gerasimos Filippatos, Stuart J Pocock, Peter Carson, James Januzzi, Subodh Verma, Hiroyuki Tsutsui, Martina Brueckmann

N Engl J Med· October 2020

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Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.
Scott D Solomon, John J V McMurray, Inder S Anand, Junbo Ge, Carolyn S P Lam, Aldo P Maggioni, Felipe Martinez, Milton Packer, Marc A Pfeffer, Burkert Pieske

October 2019

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Declining Risk of Sudden Death in Heart Failure.
Li Shen, Pardeep S Jhund, Mark C Petrie, Brian L Claggett, Simona Barlera, John G F Cleland, Henry J Dargie, Christopher B Granger, John Kjekshus, Lars Køber

N Engl J Med· July 2017

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Angiotensin-neprilysin inhibition versus enalapril in heart failure.
John J V McMurray, Milton Packer, Akshay S Desai, Jianjian Gong, Martin P Lefkowitz, Adel R Rizkala, Jean L Rouleau, Victor C Shi, Scott D Solomon, Karl Swedberg

N Engl J Med· September 2014

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What Causes Inflammation in Heart Failure With a Preserved Ejection Fraction?: Potential Role of Eicosanoid Adipokines.
Milton Packer

JACC Heart Fail· December 2025

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Adipoexosomal MicroRNAs as Adipose Tissue-Derived Messengers in Heart Failure With a Preserved Ejection Fraction.
Milton Packer

JACC Heart Fail· December 2025

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Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis.
William G Herrington, Zhaojing J Che, Rebecca Sardell, Alistair J Roddick, Parminder K Judge, Milton Packer

Lancet Diabetes Endocrinol· December 2025

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Natriuretic Peptides, Body Mass Index, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.
John W Ostrominski, Brendon L Neuen, Brian L Claggett, Inder S Anand, Akshay S Desai, Milton Packer

J Am Coll Cardiol· November 2025

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Is Type 2 Diabetes a Modifiable Risk Factor for the Evolution and Progression of Heart Failure With a Preserved Ejection Fraction?
Milton Packer, Carolyn S P Lam, Javed Butler, Faiez Zannad, Muthiah Vaduganathan

J Am Coll Cardiol· November 2025

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Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction?
Milton Packer, Javed Butler, Carolyn S P Lam, Faiez Zannad, Muthiah Vaduganathan

J Am Coll Cardiol· November 2025

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Chronic Kidney Disease in Patients With Heart Failure With a Preserved Ejection Fraction: The Underlying Role of Visceral Adiposity.
Milton Packer, Jeffrey Testani, Javed Butler, Faiez Zannad, Carolyn S P Lam

J Am Coll Cardiol· November 2025

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Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta-Analysis.
Natalie Staplin, Alistair J Roddick, Brendon L Neuen, Stefan D Anker, Deepak L Bhatt, Milton Packer

JAMA· November 2025

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SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria: A Meta-Analysis.
Brendon L Neuen, Robert A Fletcher, Stefan D Anker, Deepak L Bhatt, Javed Butler, Milton Packer

JAMA· November 2025

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Conceptual Models to Explain Heart Failure With a Preserved Ejection Fraction: a Tale of Futility, Frustration, and Perhaps, Fruition.
Milton Packer

Circulation· November 2025

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Sodium-glucose co-transporter 2 inhibitors in severe estimated glomerular filtration rate deterioration across cardiovascular-kidney- metabolic conditions: A pooled analysis of randomized trials.
João Pedro Ferreira, Pedro Marques, Stefan D Anker, Javed Butler, Gerasimos Filippatos, Milton Packer

Eur J Heart Fail· November 2025

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Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular-kidney-metabolic conditions: A pooled analysis of randomised trials.
João Pedro Ferreira, Pedro Marques, Stefan D Anker, Javed Butler, Gerasimos Filippatos, Milton Packer

Diabetes Obes Metab· November 2025

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Response by Zile et al to Letter Regarding Article, "Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity".
Michael R Zile, Barry A Borlaug, Christopher M Kramer, Milton Packer

Circulation· November 2025

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How Applicable Is the Adipokine Hypothesis to the General Population of Heart Failure and a Preserved Ejection Fraction?
Milton Packer

J Card Fail· November 2025

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Is It Time to Abandon Phenomapping of Heterogeneity to Elucidate the Mechanisms or Define the Treatment of Heart Failure with a Preserved Ejection Fraction?
Milton Packer

J Card Fail· November 2025

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Obesity, aldosterone, and natriuretic peptide in patients with heart failure and reduced ejection fraction.
Shingo Matsumoto, Jawad H Butt, Kieran F Docherty, Pardeep S Jhund, William T Abraham, Milton Packer

Cardiovasc Res· November 2025

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Evolutionary History of the Comorbidity-Driven Coronary Microvascular Endothelial Inflammation Hypothesis and Its Metamorphosis to the Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction.
Milton Packer

JACC Heart Fail· November 2025

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Vericiguat in heart failure with reduced ejection fraction: being confident in the face of uncertainty.
Antonio Cannata, Milton Packer

Eur Heart J· November 2025

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Serum Magnesium and the Effect of Empagliflozin in Heart Failure With Reduced Ejection Fraction: Findings From EMPEROR-Reduced.
João Pedro Ferreira, Stefan D Anker, Javed Butler, Francisco Vasques-Nóvoa, Pedro Marques, Milton Packer

JACC Heart Fail· October 2025

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Reply: Metabolic Health Status: A Critical Unaddressed Dimension in Obesity Phenotyping for Heart Failure With Preserved Ejection Fraction.
Barry A Borlaug, Michael R Zile, Christopher M Kramer, Milton Packer

J Am Coll Cardiol· October 2025

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Do obesity and visceral adiposity promote heart failure with reduced ejection fraction?
Milton Packer

Eur Heart J· September 2025

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Albuminuria Is the Key Driver of Kidney Benefit with Aldosterone Receptor Antagonists in Type 2 Diabetes.
João Pedro Ferreira, Luís Mendonça, Pedro Marques, João Sérgio Neves, Faiez Zannad, Milton Packer

J Am Soc Nephrol· September 2025

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Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity: A Prespecified Stratification-Based Analysis.
Milton Packer, Michael R Zile, Christopher M Kramer, Joseph M DiMaria, Seth J Baum

J Am Coll Cardiol· September 2025

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Intensity, Duration, and Context Dependency of the Responses to Nutrient Surplus and Deprivation Signaling in the Heart: Insights Into the Complexities of Cardioprotection.
Milton Packer

Circulation· September 2025

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Heart failure outcomes and empagliflozin effects in patients with heart failure and reduced ejection fraction in sinus rhythm or atrial fibrillation: Data from EMPEROR-Reduced.
Michael Böhm, Javed Butler, Amr Abdin, Gerasimos Filippatos, João Pedro Ferreira, Milton Packer

Eur J Heart Fail· September 2025

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