PubHawk
N Engl J Med July 2017 PMID 28679089

Declining Risk of Sudden Death in Heart Failure.

Li Shen, Pardeep S Jhund, Mark C Petrie, Brian L Claggett, Simona Barlera, John G F Cleland, Henry J Dargie, Christopher B Granger, John Kjekshus, Lars Køber, Roberto Latini, Aldo P Maggioni, Milton Packer, Bertram Pitt, Scott D Solomon

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Mentions

69
Peak: 8 in Jul 2020
across 6 sources since May 2019

Extended reach

426,918
potential audience

Total likes

139

Video views

846

Mentions per month

May 2019 – Aug 2025

Where it's discussed

  • X / Twitter34 posts
  • News18 articles
  • Facebook8 posts
  • YouTube4 videos
  • Blogs4 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The social discussions frequently reference major studies and trials, such as the NEJM analysis and Shen et al., emphasizing the declining rates of sudden death due to improved therapy options. The tone across posts is both analytical and optimistic, reflecting a shared recognition of the progress made in managing heart failure through medication and device-based therapies.

AgreementStrong agreement

Most discussions agree that the study shows significant improvements in reducing sudden death risk in heart failure patients due to modern therapies.

InterestHigh interest

The posts demonstrate high interest, referencing new trials, therapy advancements, and detailed analyses like the NEJM study.

EngagementHigh engagement

Many participants cite specific studies, such as the Shen et al. analysis and the EMPHASIS-HF data, indicating deep engagement and critical discussion.

ImpactHigh impact

The discussions highlight the substantial clinical impact of the findings, emphasizing how they influence treatment strategies and future research directions.

Abstract in brief

  • The study shows that the risk of sudden death in patients with heart failure and reduced ejection fraction has decreased significantly over time, especially with the introduction of medications like ACE inhibitors, ARBs, beta-blockers, and mineralocorticoid receptor antagonists.
  • The decline in sudden death rates was most notable within the first 90 days after treatment began, with a reduction from 24% in earlier trials to 10% in more recent ones, indicating improvements in both medication use and management strategies.
  • The decreased risk was observed across patients regardless of how long they had been diagnosed with heart failure, suggesting that modern treatments are beneficial for both new and long-standing cases of the condition.
Read the full abstract

Top posts

Most liked on X and Bluesky
まめたろう,MD, PhD
@mameeps · X

EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaWdHmld8V AF+HF βblocker有効な患者層 https://t.co/QlNFvsfi1I #EP大学

May 31, 2023 · 37 likes · 8 shares · 4,925 followers View post →
Benedikt Schrage
@BenediktSchrage · X

Most importantly, due to the massive improvements in medical therapies, the overall risk of SCD in patients with HFrEF has declined in the past years, as shown in this elegant study by Shen et al. https://t.co/SRjpCjvy9N 5/x

Jun 19, 2022 · 19 likes · 2 shares · 934 followers View post →
Prof Chris P Gale
@cpgale3 · X

Rationale for our ⁦@HorizonEU⁩ #PROFID RCT: ⬇️ing benefit of prophylactic ICD in #heartfailure due to novel drug classes that ⬇️ mortality & SCD ⬇️ing SCD risk over the last two decades & ⬇️ annual shock rate Complication rates of ICD therapy >10% https://t.co/DPSbj4Sjfk

Jun 18, 2023 · 16 likes · 1 share · 13,471 followers View post →
John Mandrola, MD
@drjohnm · X

This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https://t.co/bIcUNbHktJ Also — These data inform the “priors” of Bayesian interpretation of RCTs in this space. Cc @SteveStiles2 @pwendl https://t.co/rSCvumR7op

Feb 2, 2021 · 15 likes · 4 shares · 68,462 followers View post →
British Society for Heart Failure #theFword
@BSHeartFailure · X

Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med 2017; 377:41 DOI: 10.1056/NEJMoa1609758

Jul 30, 2020 · 9 likes · 5 shares · 11,450 followers View post →
Muthu Vaduganathan
@mvaduganathan · X

@GAggarwalMD @AndrewJSauer @FH_Verbrugge @djc795 @venkmurthy Shifting patterns of death across trials over time nicely demonstrated by Dr. Li Shen @PSJhund @markcpetrie20 & colleagues at @UoGHeartFailure in @NEJM Difficult to design RCTs powered for mortality alone in the current era https://t.co/UfywtNvOeY https://t.co/TUn1eyLwfy

Jul 30, 2020 · 6 likes · 3 shares · 9,131 followers View post →

All mentions

Brendon Neuen
@brendonneuen.bsky.social · Bluesky

I was specifically referring to CKD, with anticipated uptake of therapies that all reduce HF hospitalisations. Here's a slightly older analysis from the HFrEF trials, but suspect still holds true now pubmed.ncbi.nlm.nih.gov/28679089/

Jan 24, 2025 · 2 likes · 1 share View post →
Gregg Fonarow MD
@gcfmd · X

@KismetRasmu @JavedButler1 @SJGreene_md https://t.co/QmadaVdlIb

Aug 11, 2023 · 4 likes · 11,769 followers View post →
Hany Ragy
@Hragy · X

RT @cpgale3: Rationale for our ⁦@HorizonEU⁩ #PROFID RCT: ⬇️ing benefit of prophylactic ICD in #heartfailure due to novel drug classes that…

Jun 18, 2023 · 1 share · 80,360 followers View post →
Prof Chris P Gale
@cpgale3 · X

Rationale for our ⁦@HorizonEU⁩ #PROFID RCT: ⬇️ing benefit of prophylactic ICD in #heartfailure due to novel drug classes that ⬇️ mortality & SCD ⬇️ing SCD risk over the last two decades & ⬇️ annual shock rate Complication rates of ICD therapy >10% https://t.co/DPSbj4Sjfk

Jun 18, 2023 · 16 likes · 1 share · 13,471 followers View post →
lal0155
@lal0155 · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 11 followers View post →
U40心不全ネットワーク@U40HFnetwork
@U40HF · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 7,431 followers View post →
ふみいぴい
@mmmmmmmiya11 · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 392 followers View post →
色々自粛中(ガラス細工の様な繊細なハートを持つ貴公子
@ECGEPSCADEVICE · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 9,374 followers View post →
高麗謙吾@心臓
@ken_korai · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 11,135 followers View post →
ぽん@
@pharma_pon · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 964 followers View post →
Hiroyuki Sato 佐藤宏行
@foreverhero0819 · X

RT @Crypto1835: EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaW…

May 31, 2023 · 8 shares · 3,765 followers View post →
まめたろう,MD, PhD
@mameeps · X

EMPHASIS-HFにおけるAF/AFL発症 https://t.co/k2eykguX2l SGLT2阻害薬とAF/AFL発症 https://t.co/aWNkFYOHQq HFrEF　突然死リスク https://t.co/AaWdHmld8V AF+HF βblocker有効な患者層 https://t.co/QlNFvsfi1I #EP大学

May 31, 2023 · 37 likes · 8 shares · 4,925 followers View post →
Linda
@wordfinga · X

RT @BenediktSchrage: Most importantly, due to the massive improvements in medical therapies, the overall risk of SCD in patients with HFrEF…

Jun 22, 2022 · 2 shares · 4,599 followers View post →
Andrew J Sauer MD
@AndrewJSauer · X

RT @BenediktSchrage: Most importantly, due to the massive improvements in medical therapies, the overall risk of SCD in patients with HFrEF…

Jun 20, 2022 · 2 shares · 19,218 followers View post →
Benedikt Schrage
@BenediktSchrage · X

Most importantly, due to the massive improvements in medical therapies, the overall risk of SCD in patients with HFrEF has declined in the past years, as shown in this elegant study by Shen et al. https://t.co/SRjpCjvy9N 5/x

Jun 19, 2022 · 19 likes · 2 shares · 934 followers View post →
Anne-Christine Ruwald
@ARuwald · X

RT @drjohnm: This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https:/…

Feb 12, 2021 · 4 shares · 233 followers View post →
Yury Mareev
@YMareev · X

RT @drjohnm: This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https:/…

Feb 3, 2021 · 4 shares · 681 followers View post →
Martin Frydland, MD, PhD
@joyland2704 · X

RT @drjohnm: This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https:/…

Feb 2, 2021 · 4 shares · 635 followers View post →
Copenhagen Cardiovascular Research Center
@CopCard · X

RT @drjohnm: This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https:/…

Feb 2, 2021 · 4 shares · 4,147 followers View post →
John Mandrola, MD
@drjohnm · X

This is a very nice paper. (A good use of observational research). Pair with “Declining risk of SCD in Heart Failure” https://t.co/bIcUNbHktJ Also — These data inform the “priors” of Bayesian interpretation of RCTs in this space. Cc @SteveStiles2 @pwendl https://t.co/rSCvumR7op

Feb 2, 2021 · 15 likes · 4 shares · 68,462 followers View post →
John Mandrola, MD
@drjohnm · X

@ESMDcan123 @kaulcsmc @venkmurthy @brophyj @f2harrell @ADAlthousePhD Yes, https://t.co/WutoHpInZ3. This is why Danish was null https://t.co/GtxDocveuE

Dec 17, 2020 · 68,462 followers View post →
Ethical GmbH
@Ethicalgmbh · X

Declining Risk of Sudden Death in Heart Failure https://t.co/Tr0CVyaWee #clinicalresearch #clinicaltrials #endpointadjudication #electronichealthrecords #clinicalstudies #digitalsignatures #patientengagement #pharmacovigilance #eclinical https://t.co/PkTzM6dBkL

Sep 30, 2020 · 488 followers View post →
Dr H O Savage
@savodoc · X

@drstephenpettit https://t.co/hBkJWZo43f This has got to be a reasonable assumption. GDMT>>>>>Device Rx #Undefeated

Aug 29, 2020 · 900 followers View post →
Jim Moore
@moorejb57 · X

RT @BSHeartFailure: Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med…

Aug 8, 2020 · 5 shares · 166 followers View post →
Joanne Pepper (Checkley)
@jocheckers · X

RT @BSHeartFailure: Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med…

Jul 31, 2020 · 5 shares · 282 followers View post →
John Gierula PhD
@JohnGierula · X

RT @BSHeartFailure: Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med…

Jul 30, 2020 · 5 shares · 739 followers View post →
Matthew Kahn
@cardiologyMCR · X

RT @BSHeartFailure: Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med…

Jul 30, 2020 · 5 shares · 863 followers View post →
Sinead Hughes
@SineadHughes19 · X

RT @BSHeartFailure: Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med…

Jul 30, 2020 · 5 shares · 1,673 followers View post →
British Society for Heart Failure #theFword
@BSHeartFailure · X

Falling rates of sudden death in trials of patients with HeFREF with time - more than halved since 1990s. N Engl J Med 2017; 377:41 DOI: 10.1056/NEJMoa1609758

Jul 30, 2020 · 9 likes · 5 shares · 11,450 followers View post →
Amitoj Singh
@amitojdr · X

RT @mvaduganathan: @GAggarwalMD @AndrewJSauer @FH_Verbrugge @djc795 @venkmurthy Shifting patterns of death across trials over time nicely d…

Jul 30, 2020 · 3 shares · 180 followers View post →
Andrew J Sauer MD
@AndrewJSauer · X

RT @mvaduganathan: @GAggarwalMD @AndrewJSauer @FH_Verbrugge @djc795 @venkmurthy Shifting patterns of death across trials over time nicely d…

Jul 30, 2020 · 3 shares · 19,218 followers View post →
Muthu Vaduganathan
@mvaduganathan · X

@GAggarwalMD @AndrewJSauer @FH_Verbrugge @djc795 @venkmurthy Shifting patterns of death across trials over time nicely demonstrated by Dr. Li Shen @PSJhund @markcpetrie20 & colleagues at @UoGHeartFailure in @NEJM Difficult to design RCTs powered for mortality alone in the current era https://t.co/UfywtNvOeY https://t.co/TUn1eyLwfy

Jul 30, 2020 · 6 likes · 3 shares · 9,131 followers View post →
Mike Drozd
@DrMikeDrozd · X

@paton_maria @ESC @UoL_LICAMM @JohnGierula @JudithLowry1 @pswoboda81 @cpgale3 Do you mean this one? Figure 1 of https://t.co/vzue93bdVt

Jul 17, 2019 · 3 likes · 1,136 followers View post →
Cardiac Surgery Congress
@CongressCardiac · X

Declining Risk of Sudden Death in Heart Failure To know more : https://t.co/PlN7Kplo1l #cardiacconference #cardiacsurgerymeet #cardiologygathering #healthylife #cardiacrhymth #cardiolife https://t.co/N1xUkoAtsa

May 20, 2019 · 153 followers View post →
John Mandrola, MD
@drjohnm · X

Which is similar to NEJM analysis of heart failure trials here https://t.co/bIcUNbHktJ https://t.co/N2CCYdRg9L

May 20, 2019 · 4 likes · 68,462 followers View post →