Publications by authors named "Minoru Ubukata"

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Correction to "Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors".
Kazuki Otake, Yoshinori Hara, Minoru Ubukata, Masafumi Inoue, Noboru Nagahashi

J Med Chem· September 2024

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Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.
Kazuki Otake, Yoshinori Hara, Minoru Ubukata, Masafumi Inoue, Noboru Nagahashi

J Med Chem· March 2024

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Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Kazuki Otake, Minoru Ubukata, Noboru Nagahashi, Naoki Ogawa, Yoshiji Hantani

ACS Med Chem Lett· May 2023

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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.
Yuki Bessho, Tatsuo Akaki, Yoshinori Hara, Maki Yamakawa, Shingo Obika, Minoru Ubukata

Bioorg Med Chem· December 2021

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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.
Tatsuo Akaki, Yuki Bessho, Takashi Ito, Shingo Fujioka, Minoru Ubukata

Bioorg Med Chem· August 2021

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Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists.
Kazuhito Harada, Jun Mizukami, Takashi Watanabe, Genki Mori, Minoru Ubukata

Bioorg Med Chem Lett· August 2019

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Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure.
Kazuhito Harada, Jun Mizukami, Takashi Watanabe, Genki Mori, Minoru Ubukata

Bioorg Med Chem Lett· February 2019

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Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.
Tetsuya Iida, Minoru Ubukata, Ikuo Mitani, Yuichi Nakagawa, Katsuya Maeda

Eur J Med Chem· October 2018

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Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.
Makoto Shiozaki, Katsuya Maeda, Tomoya Miura, Masayuki Kotoku, Takayuki Yamasaki, Minoru Ubukata

J Med Chem· April 2011

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One-step synthesis of heteroaromatic-fused pyrrolidines via cyclopropane ring-opening reaction: application to the PKCbeta inhibitor JTT-010.
Masahiro Tanaka, Minoru Ubukata, Takafumi Matsuo, Katsutaka Yasue, Katsuya Matsumoto

Org Lett· August 2007

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Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCbeta-selective inhibitors.
Masahiro Tanaka, Shoichi Sagawa, Jun-ichi Hoshi, Fumito Shimoma, Katsutaka Yasue, Minoru Ubukata

Bioorg Med Chem· September 2006

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Rhodium-Catalyzed Intermolecular [4+2] Cycloaddition of Unactivated Substrates.
Masahiro Murakami, Minoru Ubukata, Kenichiro Itami, Yoshihiko Ito

Angew Chem Int Ed Engl· September 1998

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Iridium-Catalyzed [5 + 1] Cycloaddition: Allenylcyclopropane as a Five-Carbon Assembling Unit.
Masahiro Murakami, Kenichiro Itami, Minoru Ubukata, Itaru Tsuji, Yoshihiko Ito

J Org Chem· January 1998

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