Publications by authors named "Mirko Brunetti"

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Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies.
Simona Barone, Ivana Bello, Anna Guadagni, Carmen Cerchia, Gessica Filocamo, Mirko Brunetti

Eur J Med Chem· August 2025

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MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
Gessica Filocamo, Mirko Brunetti, Fabrizio Colaceci, Romina Sasso, Mirella Tanori

Mol Cancer Ther· June 2016

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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Olaf Kinzel, Anna Alfieri, Sergio Altamura, Mirko Brunetti, Simone Bufali

Bioorg Med Chem Lett· August 2011

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Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.
Bruno Cadot, Mirko Brunetti, Sabina Coppari, Silvia Fedeli, Emanuele de Rinaldis

Cancer Res· August 2009

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Alessandro Vannini, Cinzia Volpari, Gessica Filocamo, Elena Caroli Casavola, Mirko Brunetti

Proc Natl Acad Sci U S A· October 2004

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Mechanism of activation of human heparanase investigated by protein engineering.
Caterina Nardella, Armin Lahm, Michele Pallaoro, Mirko Brunetti, Alessandro Vannini

Biochemistry· February 2004

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A scintillation proximity active site binding assay for the hepatitis C virus serine protease.
Christian Steinkühler, Gabriella Biasiol, Mauro Cerretani, Laura Di Renzo, Mirko Brunetti

Anal Biochem· August 2002

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A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.
Frank Narjes, Konrad F Koehler, Uwe Koch, Benjamin Gerlach, Stefania Colarusso, Mirko Brunetti

Bioorg Med Chem Lett· February 2002

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