Publications by authors named "Mischa Machius"

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Editorial Expression of Concern: Munc13 CB domain is an activity-dependent Ca regulator of synaptic exocytosis.
Ok-Ho Shin, Jun Lu, Jeong-Seop Rhee, Diana R Tomchick, Zhiping P Pang, Mischa Machius

Nat Struct Mol Biol· December 2025

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Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB.
Sean McNeme, Yun Young Yim, Ashwani Kumar, Yi Li, Brandon Hughes, Mischa Machius

bioRxiv· October 2025

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Efficient pharmacological inhibition of ΔFOSB, an AP1 transcription factor, in brain.
Sean McNeme, Anil Kumar, Yun Young Yim, Brandon W Hughes, Corey St Romain, Mischa Machius

bioRxiv· October 2025

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Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function.
Hubert Lee, Nicolas Chofflet, Jianfang Liu, Shanghua Fan, Zhuoyang Lu, Mischa Machius

J Biol Chem· April 2023

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Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
Ashwani Kumar, Galina Aglyamova, Yun Young Yim, Aaron O Bailey, Haley M Lynch, Mischa Machius

Nucleic Acids Res· September 2022

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Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges.
Shanghua Fan, Shanti Pal Gangwar, Mischa Machius, Gabby Rudenko

Structure· July 2021

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Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
Harikanth Venkannagari, James M Kasper, Anurag Misra, Scott A Rush, Shanghua Fan, Mischa Machius

J Mol Biol· September 2020

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Self-assembly of the bZIP transcription factor ΔFosB.
Zhou Yin, Harikanth Venkannagari, Haley Lynch, Galina Aglyamova, Mukund Bhandari, Mischa Machius

Curr Res Struct Biol· December 2019

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Activator Protein-1: redox switch controlling structure and DNA-binding.
Zhou Yin, Mischa Machius, Eric J Nestler, Gabby Rudenko

Nucleic Acids Res· November 2017

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Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.
Shanti Pal Gangwar, Xiaoying Zhong, Suchithra Seshadrinathan, Hui Chen, Mischa Machius

Neuron· June 2017

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TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in .
Marc T Nishimura, Ryan G Anderson, Karen A Cherkis, Terry F Law, Qingli L Liu, Mischa Machius

Proc Natl Acad Sci U S A· March 2017

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Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
Andrew L McIver, Weihe Zhang, Qingyang Liu, Xinpeng Jiang, Michael A Stashko, Mischa Machius

ChemMedChem· February 2017

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Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
Xiaodong Wang, Jing Liu, Weihe Zhang, Michael A Stashko, James Nichols, Mischa Machius

ACS Med Chem Lett· December 2016

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Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Polina V Danshina, Weidong Qu, Brenda R Temple, Rafael J Rojas, Michael J Miley, Mischa Machius

Mol Hum Reprod· June 2016

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Computational de novo design of a four-helix bundle protein--DND_4HB.
Grant S Murphy, Bharatwaj Sathyamoorthy, Bryan S Der, Mischa C Machius, Surya V Pulavarti

Protein Sci· April 2015

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Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.
Weihe Zhang, Dehui Zhang, Michael A Stashko, Deborah DeRyckere, Debra Hunter, Mischa Machius

J Med Chem· December 2013

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Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
Weihe Zhang, Andrew L McIver, Michael A Stashko, Deborah DeRyckere, Brian R Branchford, Mischa Machius

J Med Chem· December 2013

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Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.
Dustin E Bosch, Adam J Kimple, Robin E Muller, Patrick M Giguère, Mischa Machius

PLoS Pathog· April 2013

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Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.
Dustin E Bosch, Adam J Kimple, Alyssa J Manning, Robin E Muller, Francis S Willard, Mischa Machius

Structure· January 2013

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Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.
Chad A Brautigam, Ranjit K Deka, Zhiming Ouyang, Mischa Machius, Gregory Knutsen

J Bacteriol· December 2012

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Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core.
Grant S Murphy, Jeffrey L Mills, Michael J Miley, Mischa Machius, Thomas Szyperski

Structure· June 2012

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Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
Jing Liu, Chao Yang, Catherine Simpson, Deborah Deryckere, Amy Van Deusen, Mischa Machius

ACS Med Chem Lett· February 2012

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Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
Bryan S Der, Mischa Machius, Michael J Miley, Jeffrey L Mills, Thomas Szyperski

J Am Chem Soc· January 2012

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Computational design of a symmetric homodimer using β-strand assembly.
P Benjamin Stranges, Mischa Machius, Michael J Miley, Ashutosh Tripathy, Brian Kuhlman

Proc Natl Acad Sci U S A· December 2011

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A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation.
Donovan C Haines, Amita Hegde, Baozhi Chen, Weiqiang Zhao, Muralidhar Bondlela, Mischa Machius

Biochemistry· October 2011

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