Publications by authors named "Mohammed AlAwadh"

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Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients.
Ali Alghubayshi, Mohammad A Alshabeeb, Dayanjan Wijesinghe, Mohammed AlAwadh, Suad Alshammari

Front Bioinform· December 2025

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Comparative study of the chemical profile, cytotoxic activity, and molecular docking of Serenoa repens extract and a pharmaceutical product.
Ehab M Mostafa, Nasser M Aldekhail, Taghreed Stum Alnusaire, Shaimaa Hussein, Alaa M Khedr, Mohammed A AlAwadh

Sci Rep· October 2025

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Exploitation of novel pyrazolo[3,4-d]pyrimidine scaffold tethered to thiazole as potential EGFR/HER2 dual kinase inhibitor to overcome lapatinib resistant breast cancer: Design, synthesis, in silico docking and molecular dynamic simulation.
Ibrahim M Salem, Osama I El-Sabbagh, Samia M Mostafa, Ismail Salama, Mohammed A Al-Awadh

Bioorg Chem· August 2025

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Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies.
Marwa A Aziz, Ibrahim M Salem, Mohammed A Al-Awadh, Abdulrahman S Alharbi, Deiaa E Elsayed Abouzed

Bioorg Chem· March 2025

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Targeted modification of furan-2-carboxaldehydes into Michael acceptor analogs yielded long-acting hemoglobin modulators with dual antisickling activities.
Abdelsattar M Omar, Osheiza Abdulmalik, Khalid M El-Say, Mohini S Ghatge, Mojisola Cyril-Olutayo

Chem Biol Drug Des· January 2024

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Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway.
Angela Tramonti, Akua K Donkor, Alessia Parroni, Faik N Musayev, Anna Barile, Mohammed AlAwadh

FEBS J· December 2023

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Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Boshi Huang, Mohini S Ghatge, Akua K Donkor, Faik N Musayev, Tanvi M Deshpande

Molecules· October 2022

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In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.
Tarek S Ibrahim, Ehab S Taher, Ebtihal Samir, Azizah M Malebari, Ahdab N Khayyat, Mohammed A AlAwadh

Molecules· July 2020

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Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.
Tarek S Ibrahim, Riham M Bokhtia, Amany M M Al-Mahmoudy, Ehab S Taher, Mohammed A AlAwadh

Bioorg Chem· June 2020

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Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity.
Tarek S Ibrahim, Taghreed A Sheha, Nader E Abo-Dya, Mohammed A AlAwadh, Nabil A Alhakamy

Bioorg Chem· June 2020

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