Publications by authors named "Motasem Melhem"

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Effect of Ethnicity on the Relationship Between Telomere Length and Metabolic Markers in Kuwait.
Thangavel Alphonse Thanaraj, Mohamed Abu-Farha, Ahmed N Albatineh, Arshad Channanath, Motasem Melhem

J Clin Endocrinol Metab· October 2025

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The miR-668 binding site variant rs1046322 on is associated with obesity in Southeast Asians.
Maha M Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Emil Anoop, Betty Chandy, Motasem Melhem

Front Endocrinol (Lausanne)· November 2023

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Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.
Abdur Rahman, Mohamed Abu-Farha, Arshad Channanath, Maha M Hammad, Emil Anoop, Motasem Melhem

Front Endocrinol (Lausanne)· November 2023

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variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts.
Mohammed Dashti, Rasheeba Nizam, Sumi Elsa John, Motasem Melhem, Arshad Channanath

Front Genet· October 2023

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rs1997623 variant and adult metabolic syndrome-Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians.
Ashraf Al Madhoun, Prashantha Hebbar, Rasheeba Nizam, Dania Haddad, Motasem Melhem

Front Genet· October 2022

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rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level.
Mohammad Qaddoumi, Prashantha Hebbar, Mohamed Abu-Farha, Aseelah Al Somaly, Motasem Melhem

Genes (Basel)· July 2022

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Identification of Maturity-Onset-Diabetes of the Young (MODY) mutations in a country where diabetes is endemic.
Hessa Al-Kandari, Dalia Al-Abdulrazzaq, Lena Davidsson, Rasheeba Nizam, Sindhu Jacob, Motasem Melhem

Sci Rep· August 2021

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Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort.
Maha M Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Preethi Cherian, Irina Al Khairi, Motasem Melhem

Front Endocrinol (Lausanne)· May 2021

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ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals.
Muath Alanbaei, Mohamed Abu-Farha, Prashantha Hebbar, Motasem Melhem, Betty S Chandy

Genes (Basel)· May 2021

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Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells.
Fatema Al-Rashed, Zunair Ahmad, Ashley J Snider, Reeby Thomas, Shihab Kochumon, Motasem Melhem

Sci Rep· April 2021

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Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait.
Mohammed Dashti, Hussain Alsaleh, Muthukrishnan Eaaswarkhanth, Sumi Elsa John, Rasheeba Nizam, Motasem Melhem

Front Genet· February 2021

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Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α.
Fatema Al-Rashed, Zunair Ahmad, Reeby Thomas, Motasem Melhem, Ashley J Snider

Sci Rep· October 2020

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Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells.
Ashraf Al Madhoun, Sulaiman K Marafie, Dania Haddad, Motasem Melhem, Mohamed Abu-Farha

Int J Mol Sci· September 2020

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Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study.
Samy M Abdel-Halim, Ashraf Al Madhoun, Rasheeba Nizam, Motasem Melhem, Preethi Cherian

Biology (Basel)· August 2020

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Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.
Prashantha Hebbar, Mohamed Abu-Farha, Fadi Alkayal, Rasheeba Nizam, Naser Elkum, Motasem Melhem

Sci Rep· January 2020

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Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population.
Prashantha Hebbar, Mohamed Abu-Farha, Anwar Mohammad, Fadi Alkayal, Motasem Melhem

Front Genet· January 2020

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Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin.
Irina AlKhairi, Preethi Cherian, Mohamed Abu-Farha, Ashraf Al Madhoun, Rasheeba Nizam, Motasem Melhem

Cells· October 2019

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Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locus [Response to Letter].
Ashraf Al Madhoun, Fahad Alnaser, Motasem Melhem, Rasheeba Nizam, Tala Al-Dabbous

Appl Clin Genet· August 2019

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Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the .
Ashraf Al Madhoun, Fahad Alnaser, Motasem Melhem, Rasheeba Nizam, Tala Al-Dabbous

Appl Clin Genet· June 2019

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Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population.
Muthukrishnan Eaaswarkhanth, Motasem Melhem, Prem Sharma, Rasheeba Nizam, Ashraf Al Madhoun

Appl Clin Genet· May 2019

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Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population.
Prashantha Hebbar, Rasheeba Nizam, Motasem Melhem, Fadi Alkayal, Naser Elkum

J Lipid Res· October 2018

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Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals.
Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M Ali

J Transl Med· January 2018

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Exome sequencing for the differential diagnosis of ciliary chondrodysplasias: Example of a WDR35 mutation case and review of the literature.
Dinu Antony, Narayanan Nampoory, Chiara Bacchelli, Motasem Melhem, Kaman Wu

Eur J Med Genet· December 2017

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The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity-related traits and mediates by interacting with Apo-A1.
Prashantha Hebbar, Fadi Alkayal, Rasheeba Nizam, Motasem Melhem, Naser Elkum

Obesity (Silver Spring)· June 2017

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Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia.
Motasem Melhem, Mohamed Abu-Farha, Dinu Antony, Ashraf Al Madhoun, Chiara Bacchelli

Eur J Haematol· March 2017

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