Publications by authors named "Murad Melhem"

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Development of a Joint Tumor Size-Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision-Making.
Herbert Struemper, Chetan Rathi, Morris Muliaditan, Sebastiaan C Goulooze, Richard C Franzese, Murad Melhem

CPT Pharmacometrics Syst Pharmacol· June 2025

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Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development.
Sebastiaan C Goulooze, Morris Muliaditan, Richard C Franzese, Alejandro Mantero, Sandra A G Visser, Murad Melhem

CPT Pharmacometrics Syst Pharmacol· April 2025

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Population pharmacokinetics and exposure-response relationships of dostarlimab in primary advanced or recurrent endometrial cancer in part 1 of RUBY.
Mita Kuchimanchi, Trine Lembrecht Jørgensen, Eva Hanze, Thierry André, Angela Jain, Murad Melhem

Br J Clin Pharmacol· March 2025

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Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper.
Divya Samineni, Karthik Venkatakrishnan, Ahmed A Othman, Yazdi K Pithavala, Srinivasu Poondru, Murad Melhem

Clin Pharmacol Ther· September 2024

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Dostarlimab, an anti-programmed death-1 monoclonal antibody, does not cause QT prolongation in patients with solid tumours: A concentration-QT analysis.
Mita Kuchimanchi, Christine Dabrowski, Sharon Lu, Murad Melhem

Br J Clin Pharmacol· July 2023

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Comparative analysis of PD-1 target engagement of dostarlimab and pembrolizumab in advanced solid tumors using ex vivo IL-2 stimulation data.
Daren Austin, Murad Melhem, Yash Gandhi, Sharon Lu, Sandra Visser

CPT Pharmacometrics Syst Pharmacol· January 2023

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Population pharmacokinetics and exposure-response of anti-programmed cell death protein-1 monoclonal antibody dostarlimab in advanced solid tumours.
Murad Melhem, Eva Hanze, Sharon Lu, Oskar Alskär, Sandra Visser

Br J Clin Pharmacol· September 2022

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Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome.
John Harrold, Per Olsson Gisleskog, Juan Jose Perez-Ruixo, Isabelle Delor, Andrew Chow, Murad Melhem

Clin Transl Sci· July 2020

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Quantification of Radiation Injury on Neutropenia and the Link between Absolute Neutrophil Count Time Course and Overall Survival in Nonhuman Primates Treated with G-CSF.
John Harrold, Per Olsson Gisleskog, Isabelle Delor, Philippe Jacqmin, Juan Jose Perez-Ruixo, Murad Melhem

Pharm Res· May 2020

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Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet.
Ping Chen, Winnie Sohn, Adimoolam Narayanan, Per Olsson Gisleskog, Murad Melhem

Br J Clin Pharmacol· June 2019

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Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions.
John David Clements, Juan Jose Perez Ruixo, John P Gibbs, Sameer Doshi, Carlos Perez Ruixo, Murad Melhem

CPT Pharmacometrics Syst Pharmacol· November 2018

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Data standards for model-informed drug development: an ISoP initiative.
Andrijana Radivojevic, Brian Corrigan, Nicholas Downie, Robert Fox, Jill Fiedler-Kelly, Murad Melhem

J Pharmacokinet Pharmacodyn· October 2018

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Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis.
Benjamin Wu, Murad Melhem, Raju Subramanian, Ping Chen, Bethlyn Jaramilla Sloey

J Clin Pharmacol· June 2018

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Pharmacokinetic-pharmacodynamic modelling of neutrophil response to G-CSF in healthy subjects and patients with chemotherapy-induced neutropenia.
Murad Melhem, Isabelle Delor, Juan Jose Pérez-Ruixo, John Harrold, Andrew Chow

Br J Clin Pharmacol· May 2018

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Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.
Ping Chen, Adimoolam Narayanan, Benjamin Wu, Per Olsson Gisleskog, John P Gibbs, Murad Melhem

Clin Pharmacokinet· January 2018

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Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis.
Liviawati Wu, Murad Melhem, Raju Subramanian, Benjamin Wu

J Pharmacokinet Pharmacodyn· February 2017

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Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
Joshua T Schiffer, David A Swan, Amalia Magaret, Lawrence Corey, Anna Wald, Murad R Melhem

Sci Transl Med· February 2016

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Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.
Sireen A R Shilbayeh, Sherwin K B Sy, Murad Melhem, Rawan Zmeili, Hartmut Derendorf

Clin Pharmacol Drug Dev· September 2015

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Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis.
Ping Chen, Murad Melhem, Jim Xiao, Mita Kuchimanchi, Juan Jose Perez Ruixo

J Clin Pharmacol· June 2015

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Population pharmacokinetic analysis for hydrocodone following the administration of hydrocodone bitartrate extended-release capsules.
Murad R Melhem, Christopher M Rubino, Stephen J Farr, Cynthia Y Robinson

Clin Pharmacokinet· October 2013

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Translation of central nervous system occupancy from animal models: application of pharmacokinetic/pharmacodynamic modeling.
Murad Melhem

J Pharmacol Exp Ther· October 2013

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Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin's lymphoma.
Joel S Owen, Murad Melhem, Julie A Passarell, Denise D'Andrea, Mona Darwish

Cancer Chemother Pharmacol· November 2010

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Development of a local perivascular paclitaxel delivery system for hemodialysis vascular access dysfunction: polymer preparation and in vitro activity.
Murad Melhem, Burnett Kelly, Jianhua Zhang, Gerald Kasting, Jinsong Li

Blood Purif· September 2006

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Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model.
Burnett Kelly, Murad Melhem, Jianhua Zhang, Gerald Kasting, Jinsong Li

Nephrol Dial Transplant· September 2006

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Vascular access in hemodialysis: issues, management, and emerging concepts.
Prabir Roy-Chaudhury, Burnett S Kelly, Murad Melhem, Jianhua Zhang, Jinsong Li

Cardiol Clin· August 2005

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