Publications by authors named "Murugaiah A M Subbaiah"

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Beyond Bioisosteres: Impact of Replacing a Benzene Ring with sp-Rich Three-Dimensional Saturated Bridged Bicyclic Match Pairs on Biotransformation, Metabolic Stability, and Other ADME Profiles.
Shruti Surendran, Sivashankaran Raju, Naveen Kalyani, Gaurav Saini, Joyson Nandha, Murugaiah A M Subbaiah

J Med Chem· October 2025

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Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach.
Yam B Poudel, Julian C Lo, Derek J Norris, Matthew Cox, Liqi He, Murugaiah A M Subbaiah

ACS Med Chem Lett· January 2025

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Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent.
Murugaiah A M Subbaiah, Thangeswaran Ramar, Maheswara Reddy, Sankara Sivaprasad Lvj, Shekhar Yeshwante

J Med Chem· November 2024

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Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy.
Murugaiah A M Subbaiah, Umasankar Mandal, Vidya Patankar, Selvakumar Bhaskaran, Ravikumar Nutakki

Eur J Med Chem· October 2024

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Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Murugaiah A M Subbaiah, Jarkko Rautio, Nicholas A Meanwell

Chem Soc Rev· February 2024

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Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
Yam B Poudel, Liqi He, Matthew Cox, Qian Zhang, Walter L Johnson, Murugaiah A M Subbaiah

ACS Med Chem Lett· February 2024

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Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
Liqi He, Meng Yao Zhang, Matthew Cox, Qian Zhang, Andrew F Donnell, Murugaiah A M Subbaiah

ACS Med Chem Lett· February 2024

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Promoting Catalytic -Selective Sulfonylation of Cyclopropanols against Conventional -Sulfonylation Using Readily Available Sulfonyl Chlorides.
Thangeswaran Ramar, Andivelu Ilangovan, Murugaiah A M Subbaiah

J Org Chem· October 2023

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Examining the Scope of Deriving β-Aryl Enones from Enol Silanes as Ketone Equivalents Pd(II)-Mediated Sequential Dehydrosilylation and Arylation.
Subba Rao Polimera, Andivelu Ilangovan, Murugaiah A M Subbaiah

J Org Chem· June 2023

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Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access β-Hydrazino Ketone Motifs.
Thangeswaran Ramar, Andivelu Ilangovan, Nicholas A Meanwell, Murugaiah A M Subbaiah

J Org Chem· November 2022

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Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.
Subba Rao Polimera, Andivelu Ilangovan, Nicholas A Meanwell, Murugaiah A M Subbaiah

J Org Chem· November 2022

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Improving Drug Delivery While Tailoring Prodrug Activation to Modulate and by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
Murugaiah A M Subbaiah, Lakshumanan Subramani, Thangeswaran Ramar, Salil Desai, Sarmistha Sinha

J Med Chem· August 2022

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Orchestrating a β-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents.
Thangeswaran Ramar, Murugaiah A M Subbaiah, Andivelu Ilangovan

J Org Chem· April 2022

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The Ligand Free Palladium(II)-Catalyzed Regioselective 1,2-Addition of Enol Silanes to Quinones to Access 4-Hydroxy-4-(2-oxo-2-arylethyl)cyclohexadien-1-ones and Synthetic Applications.
Subba Rao Polimera, Murugaiah A M Subbaiah, Andivelu Ilangovan

J Org Chem· November 2021

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Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
Murugaiah A M Subbaiah, Nicholas A Meanwell

J Med Chem· October 2021

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(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Murugaiah A M Subbaiah, Thangeswaran Ramar, Lakshumanan Subramani, Salil D Desai, Sarmistha Sinha

Eur J Med Chem· December 2020

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Utility of Organoboron Reagents in Arylation of Cyclopropanols via Chelated Pd(II) Catalysis: Chemoselective Access to β-Aryl Ketones.
Thangeswaran Ramar, Murugaiah A M Subbaiah, Andivelu Ilangovan

J Org Chem· June 2020

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Correction to "Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges".
Murugaiah A M Subbaiah

J Med Chem· November 2019

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Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
Murugaiah A M Subbaiah, Sandhya Mandlekar, Sridhar Desikan, Thangeswaran Ramar, Lakshumanan Subramani

J Med Chem· April 2019

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Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
Murugaiah A M Subbaiah, Nicholas A Meanwell, John F Kadow, Lakshumanan Subramani, Mathiazhagan Annadurai

J Med Chem· May 2018

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Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
Murugaiah A M Subbaiah

J Med Chem· March 2018

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Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.
Murugaiah A M Subbaiah, Nicholas A Meanwell, John F Kadow

Eur J Med Chem· October 2017

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