Publications by authors named "Musheng Xu"

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
Robert A Craig, Javier De Vicente, Anthony A Estrada, Jianwen A Feng, Katrina W Lexa, Musheng Xu

J Med Chem· April 2024

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Resin-based iron-manganese binary oxide for phosphate selective removal.
Jie Wang, Yongcan Jiang, Musheng Xu, Cong Han, Lichao Zhang

Environ Sci Pollut Res Int· January 2023

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Robert A Craig, Brian M Fox, Cheng Hu, Katrina W Lexa, Maksim Osipov, Musheng Xu

J Med Chem· December 2022

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Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides.
Chunliang Liu, Luke Steere, Cari McGregor, Brittany H Frederick, Timothy Pastoor, Musheng Xu

Bioorg Med Chem Lett· July 2021

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Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with Efficacy in Multiple Myeloma.
Obdulia Rabal, Edurne San José-Enériz, Xabier Agirre, Juan Antonio Sánchez-Arias, Irene de Miguel, Musheng Xu

J Med Chem· March 2021

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Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles.
Obdulia Rabal, Juan A Sánchez-Arias, Mar Cuadrado-Tejedor, Irene de Miguel, Marta Pérez-González, Musheng Xu

ACS Chem Neurosci· September 2019

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Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.
Obdulia Rabal, Juan A Sánchez-Arias, Mar Cuadrado-Tejedor, Irene de Miguel, Marta Pérez-González, Xu Musheng

ACS Chem Neurosci· March 2019

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Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces.
Obdulia Rabal, Juan Antonio Sánchez-Arias, Edurne San José-Enériz, Xabier Agirre, Irene de Miguel, Musheng Xu

J Med Chem· August 2018

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Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.
Obdulia Rabal, Edurne San José-Enériz, Xabier Agirre, Juan Antonio Sánchez-Arias, Amaia Vilas-Zornoza, Musheng Xu

J Med Chem· August 2018

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Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.
Irene de Miguel, Josune Orbe, Juan A Sánchez-Arias, José A Rodríguez, Agustina Salicio, Musheng Xu

ACS Med Chem Lett· May 2018

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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Obdulia Rabal, Juan A Sánchez-Arias, Mar Cuadrado-Tejedor, Irene de Miguel, Marta Pérez-González, Xu Musheng

Eur J Med Chem· April 2018

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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Tsutomu Akama, Yong-Kang Zhang, Yvonne R Freund, Pamela Berry, Joanne Lee, Musheng Xu

Bioorg Med Chem Lett· January 2018

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Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
Juan A Sánchez-Arias, Obdulia Rabal, Mar Cuadrado-Tejedor, Irene de Miguel, Marta Pérez-González, Xu Musheng

ACS Chem Neurosci· March 2017

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Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.
Obdulia Rabal, Juan A Sánchez-Arias, Mar Cuadrado-Tejedor, Irene de Miguel, Marta Pérez-González, Xu Musheng

J Med Chem· October 2016

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Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.
Josune Orbe, Juan A Sánchez-Arias, Obdulia Rabal, José A Rodríguez, Agustina Salicio, Musheng Xu

J Med Chem· March 2015

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Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.
Xianfeng Li, Yong-Kang Zhang, Jacob J Plattner, Weimin Mao, M R K Alley, Musheng Xu

Bioorg Med Chem Lett· February 2013

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Photogeneration and chemistry of biphenyl quinone methides from hydroxybiphenyl methanols.
Musheng Xu, Matthew Lukeman, Peter Wan

Photochem Photobiol· June 2006

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Ketonization of the remarkably strongly acidic elongated enol generated by flash photolytic decarboxylation of p-benzoylphenylacetic acid in aqueous solution.
Yvonne Chiang, A Jerry Kresge, Ikenna Onyido, John P Richard, Peter Wan, Musheng Xu

Chem Commun (Camb)· September 2005

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Photohydration and photosolvolysis of biphenyl alkenes and alcohols via biphenyl quinone methide-type intermediates and diarylmethyl carbocations.
Darryl W Brousmiche, Musheng Xu, Matthew Lukeman, Peter Wan

J Am Chem Soc· October 2003

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Excited state intramolecular redox reaction of 2-(hydroxymethyl)anthraquinone in aqueous solution.
Matthew Lukeman, Musheng Xu, Peter Wan

Chem Commun (Camb)· January 2002

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