Publications by authors named "Brian M Fox"

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Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions.
Madhuja Samaddar, Gabriel A Fitzgerald, Ann Hong Nguyen, Sonnet S Davis, Shourya Jain, Brian M Fox

Cell Rep· September 2025

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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Brian M Fox

J Biol Chem· February 2024

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Robert A Craig, Brian M Fox, Cheng Hu, Katrina W Lexa, Maksim Osipov

J Med Chem· December 2022

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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Maurits F J M Vissers, Jules A A C Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Brian M Fox

Clin Transl Sci· August 2022

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A selective prostaglandin E2 receptor subtype 2 (EP2) antagonist increases the macrophage-mediated clearance of amyloid-beta plaques.
Brian M Fox, Hilary P Beck, Philip M Roveto, Frank Kayser, Qingwen Cheng

J Med Chem· July 2015

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Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
Yosup Rew, Daqing Sun, Xuelei Yan, Hilary P Beck, Jude Canon, Brian M Fox

J Med Chem· December 2014

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Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
Ana Z Gonzalez, Zhihong Li, Hilary P Beck, Jude Canon, Ada Chen, Brian M Fox

J Med Chem· April 2014

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Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.
Brian M Fox, Kazuyuki Sugimoto, Kiyosei Iio, Atsuhito Yoshida, Jian Ken Zhang

J Med Chem· April 2014

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Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Ana Z Gonzalez, John Eksterowicz, Michael D Bartberger, Hilary P Beck, Jude Canon, Brian M Fox

J Med Chem· March 2014

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Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
Daqing Sun, Zhihong Li, Yosup Rew, Michael Gribble, Michael D Bartberger, Brian M Fox

J Med Chem· February 2014

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Structure-based design of novel inhibitors of the MDM2-p53 interaction.
Yosup Rew, Daqing Sun, Felix Gonzalez-Lopez De Turiso, Michael D Bartberger, Hilary P Beck, Brian M Fox

J Med Chem· June 2012

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Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition.
Brian M Fox, Reina Natero, Kevin Richard, Richard Connors, Philip M Roveto

Bioorg Med Chem Lett· April 2011

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Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.
Brian M Fox, Kiyosei Iio, Kexue Li, Rebeka Choi, Takashi Inaba

Bioorg Med Chem Lett· October 2010

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Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan, Brian M Fox, Marintha Rae Meckley

Bioorg Med Chem Lett· August 2006

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Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
Brian M Fox, Xiangshu Xiao, Smitha Antony, Glenda Kohlhagen, Yves Pommier

J Med Chem· July 2003

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Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model.
Muthusamy Jayaraman, Brian M Fox, Melinda Hollingshead, Glenda Kohlhagen, Yves Pommier

J Med Chem· January 2002

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