Publications by authors named "Naing Aay"

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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
James Cregg, Anne V Edwards, Stephanie Chang, Bianca J Lee, John E Knox, Naing Aay

J Med Chem· March 2025

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Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
Craig S Takeuchi, Byung Gyu Kim, Charles M Blazey, Sunghoon Ma, Henry W B Johnson, Naing Aay

J Med Chem· March 2013

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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Timothy Forsyth, Patrick C Kearney, Byung Gyu Kim, Henry W B Johnson, Naing Aay

Bioorg Med Chem Lett· December 2012

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Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.
Joerg Bussenius, Charles M Blazey, Naing Aay, Neel K Anand, Arlyn Arcalas

Bioorg Med Chem Lett· September 2012

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The design, synthesis, and biological evaluation of PIM kinase inhibitors.
Amy Lew Tsuhako, David S Brown, Elena S Koltun, Naing Aay, Arlyn Arcalas

Bioorg Med Chem Lett· June 2012

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Discovery of XL413, a potent and selective CDC7 inhibitor.
Elena S Koltun, Amy Lew Tsuhako, David S Brown, Naing Aay, Arlyn Arcalas

Bioorg Med Chem Lett· June 2012

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Discovery and characterization of an inhibitor of glucosylceramide synthase.
Steven Richards, Christopher J Larson, Elena S Koltun, Art Hanel, Vicky Chan, Naing Aay

J Med Chem· May 2012

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Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973).
Kenneth D Rice, Naing Aay, Neel K Anand, Charles M Blazey, Owen J Bowles

ACS Med Chem Lett· May 2012

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Discovery of a new class of glucosylceramide synthase inhibitors.
Elena Koltun, Steven Richards, Vicky Chan, Jason Nachtigall, Hongwang Du, Naing Aay

Bioorg Med Chem Lett· November 2011

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