Publications by authors named "Nancy Bump"

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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Steven P Langston, Stephen Grossman, Dylan England, Roushan Afroze, Neil Bence, Nancy Bump

J Med Chem· March 2021

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Nancy Bump

Nat Med· February 2018

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Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.
James M Gavin, Kara Hoar, Qing Xu, Jingya Ma, Yafang Lin, Nancy J Bump

J Biol Chem· August 2014

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Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Matthew O Duffey, Tricia J Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Nancy J Bump

J Med Chem· January 2012

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Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.
Jesse J Chen, Christopher A Tsu, James M Gavin, Michael A Milhollen, Frank J Bruzzese, Nancy J Bump

J Biol Chem· November 2011

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Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Christopher Blackburn, Cynthia Barrett, Jonathan L Blank, Frank J Bruzzese, Nancy Bump

Bioorg Med Chem Lett· November 2010

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Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit.
Christopher Blackburn, Kenneth M Gigstad, Paul Hales, Khristofer Garcia, Matthew Jones, Nancy Bump

Biochem J· September 2010

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
James E Brownell, Michael D Sintchak, James M Gavin, Hua Liao, Frank J Bruzzese, Nancy J Bump

Mol Cell· January 2010

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Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105.
Yong Jia, Christopher M Quinn, Nancy J Bump, Kevin M Clark, Anca Clabbers

Arch Biochem Biophys· September 2005

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