Publications by authors named "Nancy Ratner"

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Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas.
Niousha Ahmari, Kwangmin Choi, Jianqiang Wu, Tilat A Rizvi, Mark Jackson, Nancy Ratner

Life Sci Alliance· December 2025

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Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors.
Kyle B Williams, Alex T Larsson, Bryant J Keller, Katherine E Chaney, Rory L Williams, Nancy Ratner

Mol Cancer Ther· October 2025

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Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation.
Jay Pundavela, Ashley Hall, Samantha Anne Dinglasan, Kwangmin Choi, Tilat A Rizvi, Nancy Ratner

Cancers (Basel)· March 2025

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Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors.
Kyle B Williams, Alex T Larsson, Bryant J Keller, Katherine E Chaney, Rory L Williams, Nancy Ratner

bioRxiv· November 2024

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Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance.
Jay Pundavela, Samantha Anne Dinglasan, Melissa Touvron, Sarah A Hummel, Liang Hu, Nancy Ratner

Sci Adv· October 2024

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Corrigendum: Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.
Siddhi N Paudel, Brian J Hutzen, Katherine E Miller, Elizabeth A R Garfinkle, Chun-Yu Chen, Nancy Ratner

Front Immunol· July 2024

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Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.
Siddhi N Paudel, Brian J Hutzen, Katherine E Miller, Elizabeth A R Garfinkle, Chun-Yu Chen, Nancy Ratner

Front Immunol· July 2024

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NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14.
Jennifer Patritti-Cram, Eric P Rahrmann, Tilat A Rizvi, Katherine C Scheffer, Timothy N Phoenix, Nancy Ratner

iScience· July 2024

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C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis.
Melissa R Perrino, Niousha Ahmari, Ashley Hall, Mark Jackson, Youjin Na, Nancy Ratner

Life Sci Alliance· May 2024

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Schwann cells modulate nociception in neurofibromatosis 1.
Namrata Gr Raut, Laura A Maile, Leila M Oswalt, Irati Mitxelena, Aaditya Adlakha, Nancy Ratner

JCI Insight· January 2024

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Shedding New Light: Novel Therapies for Common Disorders in Children with Neurofibromatosis Type I.
Natasha Pillay-Smiley, Jonathan S Fletcher, Peter de Blank, Nancy Ratner

Pediatr Clin North Am· October 2023

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Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis.
Teresa González-Muñoz, Angela Di Giannatale, Susana García-Silva, Vanesa Santos, Sara Sánchez-Redondo, Nancy Ratner

Clin Cancer Res· September 2023

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Motor Function and Physiology in Youth With Neurofibromatosis Type 1.
Alexander C Doherty, David A Huddleston, Paul S Horn, Nancy Ratner, Brittany N Simpson

Pediatr Neurol· June 2023

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Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage.
Mark Jackson, Niousha Ahmari, Jianqiang Wu, Tilat A Rizvi, Elizabeth Fugate, Nancy Ratner

J Pharmacol Exp Ther· May 2023

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Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.
Youjin Na, Ashley Hall, Yanan Yu, Liang Hu, Kwangmin Choi, Nancy Ratner

Oncogene· March 2023

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Merlin tumor suppressor function is regulated by PIP2-mediated dimerization.
Robert F Hennigan, Craig S Thomson, Kye Stachowski, Nicolas Nassar, Nancy Ratner

PLoS One· February 2023

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Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Nancy Ratner

iScience· February 2023

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Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment.
Leah J Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa Perrino, Nancy Ratner

JCI Insight· September 2022

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The Need for New Treatments Targeting MPNST: The Potential of Strategies Combining MEK Inhibitors with Antiangiogenic Agents.
Teresa González-Muñoz, AeRang Kim, Nancy Ratner, Héctor Peinado

Clin Cancer Res· August 2022

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P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis.
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Nancy Ratner

Elife· March 2022

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Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis.
Anna Heinrich, Bidur Bhandary, Sarah J Potter, Nancy Ratner, Tony DeFalco

Cell Rep· October 2021

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WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth.
Craig S Thomson, Jay Pundavela, Melissa R Perrino, Robert A Coover, Kwangmin Choi, Nancy Ratner

Oncogene· June 2021

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NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas.
Brian D Weiss, Pamela L Wolters, Scott R Plotkin, Brigitte C Widemann, James H Tonsgard, Nancy Ratner

J Clin Oncol· March 2021

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Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib.
Robert Galvin, Adrienne L Watson, David A Largaespada, Nancy Ratner, Sara Osum

Curr Oncol Rep· March 2021

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Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development.
Germán L Vélez-Reyes, Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah Berner, Nancy Ratner

Cancers (Basel)· March 2021

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