Publications by authors named "Naoki Toyooka"

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Acute toxicity of frog-skin-homologous synthetic alkaloids and frog-skin extracts: miniaturized test to evaluate toxicity with Daphnia magna.
Michael Méndez-Rivera, Didier Ramírez-Morales, Abel Mora-Machado, Heike Pröhl, Ariel Rodríguez, Naoki Toyooka

Toxicon· December 2025

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Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models.
Yusuke Shintani, Atsuko Hayata-Takano, Ichiro Takasaki, Takashi Kurihara, Atsuro Miyata, Naoki Toyooka

Mol Psychiatry· September 2025

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HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice.
Maho Tsubota, Kana Sasaki, Eunkyung Shin, Yuta Okamura, Ayaka Nishimura, Naoki Toyooka

Eur J Pharmacol· July 2025

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Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice.
Ichiro Takasaki, Ryota Nagashima, Takahiro Ueda, Yuya Ashihara, Tomoya Nakamachi, Naoki Toyooka

J Pain· February 2025

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Construction of -2,6-Disubstituted Piperidine Skeleton and Its Application to the Total Synthesis of (-)-Myrtine and -Piperidine-Type Poison-Frog Alkaloids.
Takuya Okada, Kenta Eguchi, Fumiaki Hasegawa, Mir Mohd Ikhlaq, Takahiro Yoshikawa, Naoki Toyooka

J Org Chem· February 2025

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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors.
Takeshi Yokoyama, Satoru Fujiwara, Kai Nishikubo, Mineyuki Mizuguchi, Yuko Nabeshima, Naoki Toyooka

J Med Chem· January 2025

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Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor.
Takeshi Yokoyama, Kotono Hisatomi, Saki Oshima, Ichiro Tanaka, Takuya Okada, Naoki Toyooka

Eur J Med Chem· December 2024

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Involvement of Ca3.2 T-type Ca channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice.
Maho Tsubota, Yuriko Iba, Tsukasa Hatakeyama, Myu Honda, Yoshihito Kasanami, Naoki Toyooka

J Pharmacol Sci· December 2024

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Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis.
Nguyen Ngoc Thanh Luan, Takuya Okada, Takeshi Yokoyama, Mie Suzuki, Yuko Nabeshima, Naoki Toyooka

J Nat Prod· November 2024

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Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner.
Abdul Hayee, Eiji Kobayashi, Chihiro Motozono, Hiroshi Hamana, Ha Thi Viet My, Naoki Toyooka

Cells· October 2024

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Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, , and Evaluations.
Takeyoshi Yamazaki, Nguyen Duy Phan, Juthamart Maneenet, Mitsuki Yamagishi, Yuya Nishikawa, Naoki Toyooka

J Med Chem· August 2024

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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
Mineyuki Mizuguchi, Yusuke Nakagawa, Takeshi Yokoyama, Takuya Okada, Kanako Fujii, Naoki Toyooka

J Med Chem· April 2024

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Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice.
Hiroshi Tsuneki, Masanori Sugiyama, Kiyofumi Sato, Hisakatsu Ito, Sanaka Nagai, Naoki Toyooka

Eur J Pharmacol· December 2023

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Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin.
Takeshi Yokoyama, Mineyuki Mizuguchi, Yuko Nabeshima, Yusuke Nakagawa, Takuya Okada, Naoki Toyooka

FEBS J· November 2023

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Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity.
Takuya Okada, Kaho Yamabe, Michiko Jo, Yuko Sakajiri, Tomokazu Shibata, Naoki Toyooka

Bioorg Med Chem Lett· September 2023

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Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Mineyuki Mizuguchi, Takeshi Yokoyama, Takuya Okada, Yusuke Nakagawa, Kanako Fujii, Naoki Toyooka

Bioorg Med Chem· July 2023

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Design and Pharmacological Chaperone Effects of -(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase.
Atsushi Kato, Izumi Nakagome, Maki Kise, Kousuke Yoshimura, Nobutada Tanaka, Naoki Toyooka

J Med Chem· July 2023

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Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model.
Nguyen Duy Phan, Ashraf M Omar, Ikue Takahashi, Hayato Baba, Tomoyuki Okumura, Naoki Toyooka

J Nat Prod· June 2023

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Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, and Evaluation.
Suresh Awale, Hayato Baba, Nguyen Duy Phan, Min Jo Kim, Juthamart Maneenet, Naoki Toyooka

J Med Chem· June 2023

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Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.
Michiko Jo, Keiichi Koizumi, Mizuho Suzuki, Daisuke Kanayama, Yurie Watanabe, Naoki Toyooka

Bioorg Med Chem Lett· May 2023

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Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D receptors for treatment of somatic and visceral pain.
Yoshihito Kasanami, Chihiro Ishikawa, Takahiro Kino, Momoka Chonan, Naoki Toyooka

Eur J Med Chem· December 2022

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Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
Mineyuki Mizuguchi, Yusuke Nakagawa, Kishin Inui, Wakana Katayama, Yurika Sawai, Naoki Toyooka

J Med Chem· December 2022

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Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice.
Yusuke Shintani, Yui Yamano, Manato Kuta, Rei Takeshita, Kazuhiro Takuma, Naoki Toyooka

Biochem Biophys Res Commun· November 2022

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Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells.
Takuya Okada, Yuri Chino, Keita Yokoyama, Yuki Fujihashi, Nguyễn Duy Phan, Naoki Toyooka

Bioorg Med Chem· October 2022

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A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid .
Tetsuya Ishimoto, Takuya Okada, Shiho Fujisaka, Kunimasa Yagi, Kazuyuki Tobe, Naoki Toyooka

Int J Mol Sci· July 2022

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