Publications by authors named "Nathan Dascal"

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Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.
Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Nathan Dascal

Nat Commun· November 2025

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Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.
Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Nathan Dascal

bioRxiv· October 2025

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Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ subunit.
Haritha P Reddy, Tal Keren-Raifman, Galit Tabak, Nathan Dascal, Daniel Yakubovich

Front Pharmacol· May 2025

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Ethosuximide: Subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels.
Boris Shalomov, Theres Friesacher, Daniel Yakubovich, J Carlo Combista, Haritha P Reddy, Nathan Dascal

Br J Pharmacol· April 2025

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Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca channel may modulate its β-adrenergic regulation.
Shimrit Oz, Tal Keren-Raifman, Tom Sharon, Suraj Subramaniam, Tamara Pallien, Nathan Dascal

BMC Biol· November 2024

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A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.
Arianne Papa, Pedro J Del Rivero Morfin, Bi-Xing Chen, Lin Yang, Alexander N Katchman, Nathan Dascal

J Clin Invest· January 2024

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Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.
Sophie Colombo, Haritha P Reddy, Sabrina Petri, Damian J Williams, Boris Shalomov, Nathan Dascal

Front Cell Neurosci· May 2023

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A novel small-molecule selective activator of homomeric GIRK4 channels.
Meng Cui, Keman Xu, Kirin D Gada, Boris Shalomov, Michelle Ban, Nathan Dascal

J Biol Chem· June 2022

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A selectivity filter mutation provides insights into gating regulation of a K channel.
Theres Friesacher, Haritha P Reddy, Harald Bernsteiner, J Carlo Combista, Boris Shalomov, Nathan Dascal

Commun Biol· April 2022

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A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).
Boris Shalomov, Reem Handklo-Jamal, Haritha P Reddy, Neta Theodor, Amal K Bera, Nathan Dascal

J Physiol· March 2022

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Encephalopathy-causing mutations in Gβ () alter regulation of neuronal GIRK channels.
Haritha P Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A Tsemakhovich, Nathan Dascal

iScience· September 2021

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Reconstitution of β-adrenergic regulation of Ca1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Moshe Katz, Suraj Subramaniam, Orna Chomsky-Hecht, Vladimir Tsemakhovich, Veit Flockerzi, Nathan Dascal

Proc Natl Acad Sci U S A· May 2021

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A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors.
Shai Berlin, Etay Artzy, Reem Handklo-Jamal, Uri Kahanovitch, Hanna Parnas, Nathan Dascal

Front Pharmacol· August 2020

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Andersen-Tawil Syndrome Is Associated With Impaired PIP Regulation of the Potassium Channel Kir2.1.
Reem Handklo-Jamal, Eshcar Meisel, Daniel Yakubovich, Leonid Vysochek, Roy Beinart, Nathan Dascal

Front Pharmacol· May 2020

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Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.
Galit Tabak, Tal Keren-Raifman, Uri Kahanovitch, Nathan Dascal

Sci Rep· January 2019

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Lithium reduces the span of G protein-activated K (GIRK) channel inhibition in hippocampal neurons.
Nathan Dascal, Moran Rubinstein

Bipolar Disord· November 2017

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Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca1.2.
Tal Keren Raifman, Prabodh Kumar, Hannelore Haase, Enno Klussmann, Nathan Dascal

Channels (Austin)· November 2017

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Collision coupling in the GABA receptor-G protein-GIRK signaling cascade.
Uri Kahanovitch, Shai Berlin, Nathan Dascal

FEBS Lett· September 2017

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Protein kinase A regulates C-terminally truncated Ca 1.2 in Xenopus oocytes: roles of N- and C-termini of the α subunit.
Shimrit Oz, Ines Pankonien, Anouar Belkacemi, Veit Flockerzi, Enno Klussmann, Nathan Dascal

J Physiol· May 2017

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Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel.
Adva Benmocha Guggenheimer, Lior Almagor, Vladimir Tsemakhovich, Debi Ranjan Tripathy, Joel A Hirsch, Nathan Dascal

Channels (Austin)· October 2016

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Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C.
Sharon Weiss, Nathan Dascal

Curr Mol Pharmacol· August 2016

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The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels.
Nathan Dascal, Uri Kahanovitch

Int Rev Neurobiol· July 2016

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A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.
Daniel Yakubovich, Shai Berlin, Uri Kahanovitch, Moran Rubinstein, Isabella Farhy-Tselnicker, Nathan Dascal

PLoS Comput Biol· November 2015

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Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.
Uri Kahanovitch, Vladimir Tsemakhovich, Shai Berlin, Moran Rubinstein, Boaz Styr, Nathan Dascal

J Physiol· December 2014

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Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.
Isabella Farhy Tselnicker, Vladimir Tsemakhovich, Ida Rishal, Uri Kahanovitch, Carmen W Dessauer, Nathan Dascal

Proc Natl Acad Sci U S A· April 2014

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