Publications by authors named "Nathan Hatcher"

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Glucosylsphingosine is a potential fluid-based biomarker of lysosomal dysfunction in Cln3 mice.
Hallie Wald, Stephanie Cicalese, Lihang Yao, Nathan Hatcher, Weiwei Luo

Neurobiol Dis· October 2025

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Deficiency in NPC2 results in disruption of mitochondria-late endosome/lysosomes contact sites and endo-lysosomal lipid dyshomeostasis.
Raffaele Pastore, Lihang Yao, Nathan Hatcher, Martin Helley, Janet Brownlees

Sci Rep· January 2025

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Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture.
Michiel Vandenbosch, Shadrack M Mutuku, Maria José Q Mantas, Nathan H Patterson, Tucker Hallmark, Nathan G Hatcher

Anal Chem· December 2023

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Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease.
Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher

NPJ Parkinsons Dis· May 2023

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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Anthony J Roecker, Kathy M Schirripa, H Marie Loughran, Ling Tong, Tao Liang, Nathan G Hatcher

ACS Med Chem Lett· February 2023

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Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
Casey L Mahoney-Crane, Megha Viswanathan, Dreson Russell, Rachel A C Curtiss, Jennifer Freire, Nathan G Hatcher

J Neurosci· January 2023

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Proteomic Discovery and Validation of Novel Fluid Biomarkers for Improved Patient Selection and Prediction of Clinical Outcomes in Alzheimer's Disease Patient Cohorts.
Shivangi Awasthi, Daniel S Spellman, Nathan G Hatcher

Proteomes· August 2022

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Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes.
Nanyan Rena Zhang, Nathan G Hatcher, Kim Ekroos, Komal Kedia, Monika Kandebo

J Lipid Res· June 2022

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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.
Santhosh Satapati, Daniel P Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Nathan G Hatcher

SLAS Discov· January 2022

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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A Gretzula, Monika Kandebo, Nathan G Hatcher

Neurobiol Dis· November 2021

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High-defined quantitative snapshots of the ganglioside lipidome using high resolution ion mobility SLIM assisted shotgun lipidomics.
Kelly L Wormwood Moser, Gregory Van Aken, Daniel DeBord, Nathan Galen Hatcher, Laura Maxon

Anal Chim Acta· February 2021

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LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.
Emily M Rocha, Briana R De Miranda, Sandra Castro, Robert Drolet, Nathan G Hatcher

Neurobiol Dis· February 2020

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Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock.
Norman Atkins, Shifang Ren, Nathan Hatcher, Penny W Burgoon, Jennifer W Mitchell

ACS Chem Neurosci· August 2018

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cAMP, Ca, pH, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug Pleurobranchaea californica.
Daniel J Green, Rong-Chi Huang, Leland Sudlow, Nathan Hatcher, Kurt Potgieter

ACS Chem Neurosci· August 2018

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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.
Marija Usenovic, Shahriar Niroomand, Robert E Drolet, Lihang Yao, Renee C Gaspar, Nathan G Hatcher

J Neurosci· October 2015

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Neuromodulatory control of a goal-directed decision.
Keiko Hirayama, Leonid L Moroz, Nathan G Hatcher, Rhanor Gillette

PLoS One· April 2015

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In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.
Jose Castro-Perez, Nathan Hatcher, Nana Kofi Karikari, Sheng-Ping Wang, Vivienne Mendoza

Rapid Commun Mass Spectrom· November 2014

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Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies.
Qian Zhang, Daniel S Spellman, Yaoli Song, Bernard Choi, Nathan G Hatcher

Anal Chem· September 2014

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Fibrinogen α-chain-derived peptide is upregulated in hippocampus of rats exposed to acute morphine injection and spontaneous alternation testing.
Agatha E Maki, Kenneth A Morris, Kasia Catherman, Xian Chen, Nathan G Hatcher

Pharmacol Res Perspect· June 2014

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A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.
Mary J Savage, Juliya Kalinina, Abigail Wolfe, Katherine Tugusheva, Rachel Korn, Nathan G Hatcher

J Neurosci· February 2014

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Synthesis, accumulation, and release of d-aspartate in the Aplysia californica CNS.
Cory Scanlan, Ting Shi, Nathan G Hatcher, Stanislav S Rubakhin, Jonathan V Sweedler

J Neurochem· December 2010

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Nitric oxide potentiates cAMP-gated cation current by intracellular acidification in feeding neurons of pleurobranchaea.
Kurt Potgieter, Nathan G Hatcher, Rhanor Gillette, Catherine R McCrohan

J Neurophysiol· August 2010

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Composite modulatory feedforward loop contributes to the establishment of a network state.
Jin-Sheng Wu, Ferdinand S Vilim, Nathan G Hatcher, Michael R Due, Jonathan V Sweedler

J Neurophysiol· April 2010

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Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors.
Ferdinand S Vilim, Kosei Sasaki, Jurgen Rybak, Vera Alexeeva, Elizabeth C Cropper, Nathan Hatcher

J Neurosci· January 2010

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Neuropeptide Release is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome.
Suresh P Annangudi, Agatha E Luszpak, Soong Ho Kim, Shifang Ren, Nathan G Hatcher

ACS Chem Neurosci· January 2010

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