Publications by authors named "Sarah Jinn"

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Glucosylsphingosine is a potential fluid-based biomarker of lysosomal dysfunction in Cln3 mice.
Hallie Wald, Stephanie Cicalese, Lihang Yao, Nathan Hatcher, Weiwei Luo, Sarah Jinn

Neurobiol Dis· October 2025

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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
H Marie Loughran, Kathy M Schirripa, Anthony J Roecker, Michael J Breslin, Ling Tong, Sarah Jinn

ACS Med Chem Lett· January 2024

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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
Anthony J Roecker, Kathy M Schirripa, H Marie Loughran, Ling Tong, Tao Liang, Sarah Jinn

ACS Med Chem Lett· February 2023

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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Mali Cosden, Sarah Jinn, Lihang Yao, Cheryl A Gretzula, Monika Kandebo

Neurobiol Dis· November 2021

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Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.
Renee C Gentzel, Dawn Toolan, Sarah Jinn, Joel B Schachter, Lei Ma

Neurobiol Aging· October 2021

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Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.
Sarah Jinn, Cornelis Blauwendraat, Dawn Toolan, Cheryl A Gretzula, Robert E Drolet

Hum Mol Genet· October 2019

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TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Sarah Jinn, Robert E Drolet, Paige E Cramer, Andus Hon-Kit Wong, Dawn M Toolan

Proc Natl Acad Sci U S A· February 2017

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snoRNA U17 regulates cellular cholesterol trafficking.
Sarah Jinn, Katrina A Brandis, Aileen Ren, Anita Chacko, Nicole Dudley-Rucker

Cell Metab· June 2015

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Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular cholesterol trafficking.
Katrina A Brandis, Sarah Gale, Sarah Jinn, Stephen J Langmade, Nicole Dudley-Rucker

J Biol Chem· December 2013

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