Publications by authors named "Neil Farrow"

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Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics.
Bin Hu, Michael Rotherham, Neil Farrow, Paul Roach, Jon Dobson

Int J Mol Sci· September 2022

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Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Joshua S Alford, John W Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Neil A Farrow

ACS Med Chem Lett· July 2022

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Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
John W Lampe, Joshua S Alford, P Ann Boriak-Sjodin, Dorothy Brach, Kat Cosmopoulos, Neil A Farrow

ACS Med Chem Lett· October 2021

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Indole Inhibitors of MMP-13 for Arthritic Disorders.
Steven J Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R Proudfoot, Neil A Farrow

ACS Omega· July 2021

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X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains.
Eric T Larson, Debra L Brennan, Eugene R Hickey, Raj Ganesan, Rachel Kroe-Barrett, Neil A Farrow

Protein Sci· July 2020

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Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
Xiang Li, Marie Anderson, Delphine Collin, Ingo Muegge, John Wan, Neil A Farrow

J Biol Chem· July 2017

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Development of Three Orthogonal Assays Suitable for the Identification and Qualification of PIKfyve Inhibitors.
Kylie Fogarty, Mohammed Kashem, Andras Bauer, Alexandra Bernardino, Debra Brennan, Neil Farrow

Assay Drug Dev Technol· July 2017

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Crystal structure of human GDF11.
Anil K Padyana, Bhamini Vaidialingam, David B Hayes, Priyanka Gupta, Michael Franti, Neil A Farrow

Acta Crystallogr F Struct Biol Commun· March 2016

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Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13.
Steven J Taylor, Asitha Abeywardane, Shuang Liang, Ingo Muegge, Anil K Padyana, Neil A Farrow

J Med Chem· August 2015

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Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting.
Munitta Muthana, Aneurin J Kennerley, Russell Hughes, Ester Fagnano, Jay Richardson, Neil Farrow

Nat Commun· August 2015

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Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications.
Eva Céspedes, James M Byrne, Neil Farrow, Sandhya Moise, Victoria S Coker

Nanoscale· November 2014

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Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.
Steven J Taylor, Asitha Abeywardane, Shuang Liang, Ingo Muegge, Anil K Padyana, Neil A Farrow

J Med Chem· December 2011

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Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.
Ho Yin Lo, Peter A Nemoto, Jin Mi Kim, Ming-Hong Hao, Kevin C Qian, Neil A Farrow

Bioorg Med Chem Lett· August 2011

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Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Ho Yin Lo, Chuk C Man, Roman W Fleck, Neil A Farrow, Richard H Ingraham

Bioorg Med Chem Lett· November 2010

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SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability.
Donghong Amy Gao, Zhaoming Xiong, Alexander Heim-Riether, Laura Amodeo, E Michael August, Neil A Farrow

Bioorg Med Chem Lett· September 2010

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Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Anne B Eldrup, Fariba Soleymanzadeh, Neil A Farrow, Alison Kukulka, Stéphane De Lombaert

Bioorg Med Chem Lett· January 2010

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Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
Anne B Eldrup, Fariba Soleymanzadeh, Steven J Taylor, Ingo Muegge, Neil A Farrow

J Med Chem· October 2009

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Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.
Steven J Taylor, Fariba Soleymanzadeh, Anne B Eldrup, Neil A Farrow, Ingo Muegge

Bioorg Med Chem Lett· October 2009

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Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Alexander Heim-Riether, Steven J Taylor, Shuang Liang, Donghong Amy Gao, Zhaoming Xiong, Neil A Farrow

Bioorg Med Chem Lett· September 2009

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Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor.
Rachel R Kroe, Martha A Baker, Martha P Brown, Neil A Farrow, Elda Gautschi

Biophys Chem· July 2007

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Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR.
Sharon J Archer, Daniel M Camac, Zhongren J Wu, Neil A Farrow, Peter J Domaille

Chem Biol· January 2002

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