Publications by authors named "Neil R Stokes"

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Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Amanda Lyons, James Kirkham, Kevin Blades, David Orr, Elizabeth Dauncey, Neil R Stokes

Bioorg Med Chem Lett· June 2022

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Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.
David H McGarry, Ian R Cooper, Rolf Walker, Catherine E Warrilow, Mark Pichowicz, Neil R Stokes

Bioorg Med Chem Lett· September 2018

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Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Cédric Charrier, Anne-Marie Salisbury, Victoria J Savage, Thomas Duffy, Emmanuel Moyo, Neil R Stokes

Antimicrob Agents Chemother· May 2017

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In vitro biological evaluation of novel broad-spectrum isothiazolone inhibitors of bacterial type II topoisomerases.
Cédric Charrier, Anne-Marie Salisbury, Victoria J Savage, Emmanuel Moyo, Henry Forward, Neil R Stokes

J Antimicrob Chemother· October 2016

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Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.
Victoria J Savage, Cédric Charrier, Anne-Marie Salisbury, Helen Box, Nathan Chaffer-Malam, Neil R Stokes

Antimicrob Agents Chemother· September 2016

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Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Ian R Cooper, Andrew J McCarroll, David McGarry, James Kirkham, Mark Pichowicz, Neil R Stokes

Bioorg Med Chem Lett· September 2016

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Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV.
Victoria J Savage, Cédric Charrier, Anne-Marie Salisbury, Emmanuel Moyo, Henry Forward, Neil R Stokes

J Antimicrob Chemother· July 2016

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Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.
James T Palmer, Lorraine C Axford, Stephanie Barker, James M Bennett, Michael Blair, Neil R Stokes

Bioorg Med Chem Lett· September 2014

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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.
Neil R Stokes, Nicola Baker, James M Bennett, Pramod K Chauhan, Ian Collins

Bioorg Med Chem Lett· January 2014

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Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.
Neil R Stokes, Helena B Thomaides-Brears, Stephanie Barker, James M Bennett, Joanne Berry

Antimicrob Agents Chemother· December 2013

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Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.
Lorraine C Axford, Piyush K Agarwal, Kelly H Anderson, Laura N Andrau, John Atherall, Neil R Stokes

Bioorg Med Chem Lett· December 2013

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Characterization of three novel mechanosensitive channel activities in Escherichia coli.
Michelle D Edwards, Susan Black, Tim Rasmussen, Akiko Rasmussen, Neil R Stokes

Channels (Austin)· April 2013

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An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
Neil R Stokes, Nicola Baker, James M Bennett, Joanne Berry, Ian Collins

Antimicrob Agents Chemother· January 2013

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Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.
David J Haydon, James M Bennett, David Brown, Ian Collins, Greta Galbraith, Neil R Stokes

J Med Chem· May 2010

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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Neil R Stokes

Bioorg Med Chem Lett· January 2009

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An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
David J Haydon, Neil R Stokes, Rebecca Ure, Greta Galbraith, James M Bennett

Science· September 2008

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Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay.
Neil R Stokes, Jörg Sievers, Stephanie Barker, James M Bennett, David R Brown

J Biol Chem· December 2005

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Transcriptional responses of intestinal epithelial cells to infection with Vibrio cholerae.
Neil R Stokes, Xin Zhou, Stephen J Meltzer, James B Kaper

Infect Immun· July 2004

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A role for mechanosensitive channels in survival of stationary phase: regulation of channel expression by RpoS.
Neil R Stokes, Heath D Murray, Chandrasekaran Subramaniam, Richard L Gourse, Petra Louis

Proc Natl Acad Sci U S A· December 2003

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