Publications by authors named "Nicholas A Kennedy"

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Clinical utility of pre-treatment 4-digit resolution HLA genotyping to guide anti-TNF choice and concomitant immunomodulator use.
Phoebe Hodges, Christopher Roberts, Miles Parkes, Nicholas A Kennedy, James Goodhand

J Crohns Colitis· December 2025

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Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
Rachel Nice, Simeng Lin, Neil Chanchlani, Claire Bewshea, Nicholas A Kennedy

J Appl Lab Med· November 2025

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Gut microbiome comparability between DNA extraction kits.
Gregory R Young, Nurulamin Noor, Aryan Khirwadkar, Lauren C Beck, Mohmmed Tauseef Sharip, Nicholas A Kennedy

Gut· September 2025

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Triaging colorectal urgent referrals in the COVID-19 era using faecal immunochemical testing: a prospective UK real-world multicentre cohort study.
Gareth Walker, Supriya Balasubramanya, Joel Bowen, Nedal Debab, Robert Bethune, Nicholas A Kennedy

BMJ Open Gastroenterol· July 2025

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Developing an adaptive platform trial for evaluation of medical treatments for Crohn's disease.
Nurulamin M Noor, Shellie J Radford, Babak Choodari-Oskooei, Morris Gordon, Ailsa L Hart, Nicholas A Kennedy

Nat Rev Gastroenterol Hepatol· June 2025

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Efficacy and Safety of Infliximab and Vedolizumab Maintenance Therapy in Patients with Crohn's Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis.
Bruce E Sands, Laurent Peyrin-Biroulet, Stefan Schreiber, Silvio Danese, Alessandro Armuzzi, Nicholas A Kennedy

J Clin Med· June 2025

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Management of diarrhoea in patients with stable ulcerative colitis with low FODMAP diet, amitriptyline, ondansetron or loperamide: the MODULATE RCT.
Lauren A Moreau, Alexander Charles Ford, Matthew James Brookes, Sandra Graca, Elspeth Guthrie, Nicholas A Kennedy

Health Technol Assess· March 2025

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Evaluation of intestinal biopsy tissue preservation methods to facilitate large-scale mucosal microbiota research.
Nicola J Wyatt, Hannah Watson, Gregory R Young, Mary Doona, Ned Tilling, Nicholas A Kennedy

EBioMedicine· February 2025

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Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn's Disease.
Simeng Lin, Eilis Hannon, Mark Reppell, Jeffrey F Waring, Nizar Smaoui, Nicholas A Kennedy

J Crohns Colitis· August 2024

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Real-world effectiveness of upadacitinib in Crohn's disease: a UK multicentre retrospective cohort study.
Alexander Thomas Elford, Maria Bishara, Nikolas Plevris, Beatriz Gros, Nathan Constantine-Cooke, Nicholas A Kennedy

Frontline Gastroenterol· July 2024

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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
Neil Chanchlani, Simeng Lin, Claire Bewshea, Benjamin Hamilton, Amanda Thomas, Nicholas A Kennedy

Lancet Gastroenterol Hepatol· June 2024

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A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.
Nurulamin M Noor, James C Lee, Simon Bond, Francis Dowling, Biljana Brezina, Nicholas A Kennedy

Lancet Gastroenterol Hepatol· May 2024

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Baseline TREM-1 Whole Blood Gene Expression Does Not Predict Response to Adalimumab Treatment in Patients with Ulcerative Colitis or Crohn's Disease in the SERENE Studies.
Bram Verstockt, Valerie Pivorunas, Naim Al Mahi, Nizar Smaoui, Heath Guay, Nicholas A Kennedy

J Crohns Colitis· April 2024

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Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib.
Zhigang Liu, James L Alexander, Kai Yee Eng, Hajir Ibraheim, Sulak Anandabaskaran, Nicholas A Kennedy

J Crohns Colitis· April 2024

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Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine.
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Ciara Kennedy

BMJ Open· April 2024

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Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients.
Benjamin Y H Bai, Mark Reppell, Nizar Smaoui, Jeffrey F Waring, Valerie Pivorunas, Nicholas A Kennedy

J Crohns Colitis· March 2024

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Validation of the IBD-Control Questionnaire across different sociodemographic and clinical subgroups: secondary analysis of a nationwide electronic survey.
Gerum G Gebeyehu, Frederick Taylor, Liz Dobson, J R Fraser Cummings, Stuart Bloom, Nicholas A Kennedy

J Crohns Colitis· February 2024

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Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Natalie Yu, Danujan Sriranganathan, Gareth J Walker, Aleksejs Sazonovs, Helen Wilding, Nicholas A Kennedy

J Crohns Colitis· December 2023

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Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study.
Zhigang Liu, James L Alexander, Kaixing Le, Xin Zhou, Hajir Ibraheim, Nicholas A Kennedy

EClinicalMedicine· October 2023

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Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn's Disease (TOPPIC).
Nicholas T Ventham, Nicholas A Kennedy, Rahul Kalla, Alex T Adams, Alexandra Noble

Cell Mol Gastroenterol Hepatol· August 2023

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Pretreatment Vitamin D Concentrations Do Not Predict Therapeutic Outcome to Anti-TNF Therapies in Biologic-Naïve Patients With Active Luminal Crohn's Disease.
Neil Chanchlani, Simeng Lin, Rebecca Smith, Christopher Roberts, Rachel Nice, Nicholas A Kennedy

Crohns Colitis 360· July 2023

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Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease.
Maja Hanić, Frano Vučković, Helena Deriš, Claire Bewshea, Simeng Lin, Nicholas A Kennedy

Biomolecules· June 2023

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Opioid use and associated factors in 1676 patients with inflammatory bowel disease: a multicentre quality improvement project.
Samantha Baillie, Jimmy K Limdi, Ash Bassi, Aileen Fraser, Gareth Parkes, Nicholas A Kennedy

Frontline Gastroenterol· June 2023

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Establishing key performance indicators for inflammatory bowel disease in the UK.
Mohammed Nabil Quraishi, Elizabeth Dobson, Rachel Ainley, Shahida Din, Ruth Wakeman, Nicholas A Kennedy

Frontline Gastroenterol· May 2023

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The importance of high-quality 'big data' in the application of artificial intelligence in inflammatory bowel disease.
James J Ashton, Johanne Brooks-Warburton, Patrick B Allen, Tony C Tham, Sami Hoque, Nicholas A Kennedy

Frontline Gastroenterol· November 2022

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