Publications by authors named "Simeng Lin"

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Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
Rachel Nice, Simeng Lin, Neil Chanchlani, Claire Bewshea, Nicholas A Kennedy

J Appl Lab Med· November 2025

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Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource.
Christopher Roberts, Jaime Peters, Aleksejs Sazonvos, Neil Goodman, Mohmmed Sharip, Simeng Lin, Christian Selinger

Aliment Pharmacol Ther· September 2025

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Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn's Disease.
Simeng Lin, Eilis Hannon, Mark Reppell, Jeffrey F Waring, Nizar Smaoui

J Crohns Colitis· August 2024

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Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification.
Anish Dattani, Elena Corujo-Simon, Arthur Radley, Tiam Heydari, Yasaman Taheriabkenar, Simeng Lin

Cell Stem Cell· July 2024

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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
Neil Chanchlani, Simeng Lin, Claire Bewshea, Benjamin Hamilton, Amanda Thomas

Lancet Gastroenterol Hepatol· June 2024

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Baseline TREM-1 Whole Blood Gene Expression Does Not Predict Response to Adalimumab Treatment in Patients with Ulcerative Colitis or Crohn's Disease in the SERENE Studies.
Bram Verstockt, Valerie Pivorunas, Naim Al Mahi, Nizar Smaoui, Heath Guay, Simeng Lin

J Crohns Colitis· April 2024

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Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients.
Benjamin Y H Bai, Mark Reppell, Nizar Smaoui, Jeffrey F Waring, Valerie Pivorunas, Simeng Lin

J Crohns Colitis· March 2024

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Pretreatment Vitamin D Concentrations Do Not Predict Therapeutic Outcome to Anti-TNF Therapies in Biologic-Naïve Patients With Active Luminal Crohn's Disease.
Neil Chanchlani, Simeng Lin, Rebecca Smith, Christopher Roberts, Rachel Nice

Crohns Colitis 360· July 2023

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Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease.
Maja Hanić, Frano Vučković, Helena Deriš, Claire Bewshea, Simeng Lin

Biomolecules· June 2023

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Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic.
Nicholas A Kennedy, Malik Janjua, Neil Chanchlani, Simeng Lin, Claire Bewshea, Merlin Davies

Gut· February 2023

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Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.
Zhigang Liu, Kaixing Le, Xin Zhou, James L Alexander, Simeng Lin

Lancet Gastroenterol Hepatol· February 2023

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The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients.
James L Alexander, Benjamin H Mullish, Nathan P Danckert, Zhigang Liu, Marton L Olbei, Simeng Lin, Caroline Sands

EBioMedicine· February 2023

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Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study.
Neil Chanchlani, Simeng Lin, Marcus K Auth, Chai Leng Lee, Helena Robbins, Aisling Murphy, Christian P Selinger

Aliment Pharmacol Ther· October 2022

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Understanding anti-TNF treatment failure: does serum triiodothyronine-to-thyroxine (T3/T4) ratio predict therapeutic outcome to anti-TNF therapies in biologic-naïve patients with active luminal Crohn's disease?
Simeng Lin, Neil Chanchlani, Isabel Carbery, Malik Janjua, Rachel Nice, Christian P Selinger

Aliment Pharmacol Ther· September 2022

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Recent advances in clinical practice: management of inflammatory bowel disease during the COVID-19 pandemic.
Simeng Lin, Louis Hs Lau, Neil Chanchlani, Nicholas A Kennedy, Siew C Ng

Gut· July 2022

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Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients.
Neil Chanchlani, Simeng Lin, Desmond Chee, Benjamin Hamilton, Rachel Nice

J Crohns Colitis· March 2022

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Nitrogen concentration acting as an environmental signal regulates cyanobacterial EPS excretion.
Long Qian, Xingwang Ye, Jingshang Xiao, Simeng Lin, Hongyu Wang, Zulin Zhang

Chemosphere· March 2022

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Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
Simeng Lin, Nicholas A Kennedy, Aamir Saifuddin, Diana Muñoz Sandoval, Catherine J Reynolds, Kai-Min Lin

Nat Commun· March 2022

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Patient-led Remote IntraCapillary pharmacoKinetic Sampling (fingerPRICKS) for Therapeutic Drug Monitoring in patients with Inflammatory Bowel Disease.
Desmond Chee, Rachel Nice, Ben Hamilton, Edward Jones, Sarah Hawkins, Simeng Lin

J Crohns Colitis· February 2022

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Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD.
Nicholas A Kennedy, Simeng Lin, James R Goodhand, Neil Chanchlani, Benjamin Hamilton

Gut· October 2021

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Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
Nicholas A Kennedy, James R Goodhand, Claire Bewshea, Rachel Nice, Desmond Chee, Simeng Lin, Christian P Selinger

Gut· May 2021

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Root-cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease.
Claire Gordon, Desmond Chee, Ben Hamilton, Neel M Heerasing, Peter Hendy, Simeng Lin

Aliment Pharmacol Ther· January 2021

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Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment.
Simeng Lin, Harry D Green, Peter Hendy, Neel M Heerasing, Neil Chanchlani, Ellina Lytvyak

J Crohns Colitis· December 2020

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Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study.
Gareth J Walker, Neil Chanchlani, Amanda Thomas, Simeng Lin, Lucy Moore

Arch Dis Child· October 2020

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Quality improvement project identifies factors associated with delay in IBD diagnosis.
Gareth J Walker, Simeng Lin, Neil Chanchlani, Amanda Thomas, Peter Hendy

Aliment Pharmacol Ther· August 2020

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