Publications by authors named "Nicholas Alp"

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Comparison of low-density lipoprotein cholesterol equations in patients with dyslipidaemia receiving cholesterol ester transfer protein inhibition.
Seth S Martin, Marc Ditmarsch, Mark Simmons, Nicholas Alp, Traci Turner

Eur Heart J Cardiovasc Pharmacother· February 2023

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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.
Mason W Freeman, Yuan-Di Halvorsen, William Marshall, Mackenzie Pater, Jon Isaacsohn, Nicholas Alp

N Engl J Med· February 2023

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Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial.
Stephen J Nicholls, Marc Ditmarsch, John J Kastelein, Scott P Rigby, Douglas Kling, Nicholas John Alp

Nat Med· August 2022

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Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth.
Surawee Chuaiphichai, Grace Z Yu, Cheryl M J Tan, Christopher Whiteman, Gillian Douglas, Nicholas J Alp

Hypertension· December 2021

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A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Gillian Douglas, Ashley B Hale, Mark J Crabtree, Brent J Ryan, Alex Hansler, Nicholas J Alp

Dev Biol· March 2015

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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Surawee Chuaiphichai, Eileen McNeill, Gillian Douglas, Mark J Crabtree, Jennifer K Bendall, Nicholas J Alp

Hypertension· September 2014

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Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction.
Florim Cuculi, Erica Dall'Armellina, Cedric Manlhiot, Alberto R De Caterina, Sharon Colyer, Nicholas J Alp

Eur Heart J· August 2014

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Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.
Gillian Douglas, Erik Van Kampen, Ashley B Hale, Eileen McNeill, Jyoti Patel, Nicholas J Alp

Eur Heart J· November 2013

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Unique blood pressure characteristics in mother and offspring after early onset preeclampsia.
Merzaka Lazdam, Arancha de la Horra, Jonathan Diesch, Yvonne Kenworthy, Esther Davis, Nicholas Alp

Hypertension· November 2012

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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Ricardo Carnicer, Ashley B Hale, Silvia Suffredini, Xing Liu, Svetlana Reilly, Nicholas J Alp

Circ Res· August 2012

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Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
An L Moens, Elizabeth A Ketner, Eiki Takimoto, Tim S Schmidt, Charles A O'Neill, Nicholas J Alp

J Mol Cell Cardiol· October 2011

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Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.
Svetlana N Reilly, Raja Jayaram, Keshav Nahar, Charalambos Antoniades, Sander Verheule, Nicholas J Alp

Circulation· September 2011

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Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia.
Nimit C Shah, Shahzad M Munir, Nicholas J Alp

JACC Cardiovasc Interv· August 2011

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Acute myocarditis mimicking reverse Takotsubo cardiomyopathy.
Theodoros D Karamitsos, Sacha Bull, Vanessa Ferreira, Nicholas J Alp, Stefan Neubauer

Circulation· January 2011

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Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.
Irina A Ionova, Jeannette Vásquez-Vivar, Brian C Cooley, Ashwani K Khanna, Jennifer Whitsett, Nicholas J Alp

Am J Physiol Heart Circ Physiol· July 2010

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Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?
Merzaka Lazdam, Arancha de la Horra, Alex Pitcher, Zola Mannie, Jonathan Diesch, Nicholas Alp

Hypertension· July 2010

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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
Tim S Schmidt, Eileen McNeill, Gillian Douglas, Mark J Crabtree, Ashley B Hale, Alphonsus Cheng, Nicholas J Alp

Clin Sci (Lond)· May 2010

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Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
Mark J Crabtree, Amy L Tatham, Ashley B Hale, Nicholas J Alp, Keith M Channon

J Biol Chem· October 2009

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GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
Amy L Tatham, Mark J Crabtree, Nicholas Warrick, Shijie Cai, Nicholas J Alp

J Biol Chem· May 2009

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Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding.
Janet Chamberlain, Sheila Francis, Zoe Brookes, Gary Shaw, Delyth Graham, Nicholas J Alp

PLoS One· May 2009

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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
Mark J Crabtree, Amy L Tatham, Yasir Al-Wakeel, Nicholas Warrick, Ashley B Hale, Nicholas J Alp

J Biol Chem· January 2009

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CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Ziad A Ali, Christina A Bursill, Gillian Douglas, Eileen McNeill, Marianna Papaspyridonos, Nicholas J Alp

Circulation· September 2008

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GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Charalambos Antoniades, Cheerag Shirodaria, Tim Van Assche, Colin Cunnington, Irmgard Tegeder, Nicholas J Alp

J Am Coll Cardiol· July 2008

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Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
An L Moens, Eiki Takimoto, Carlo G Tocchetti, Khalid Chakir, Djahida Bedja, Nicholas J Alp

Circulation· May 2008

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Role of Chlamydia pneumoniae in atherosclerosis.
Caroline Watson, Nicholas J Alp

Clin Sci (Lond)· April 2008

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