Publications by authors named "Nicholas D Mazarakis"

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Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration.
Rachel E James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Nicholas D Mazarakis

Brain· December 2022

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Not Just Loss-of-Function Variations: Identification of a Hypermorphic Variant in a Patient With a CDKL5 Missense Substitution.
Angelisa Frasca, Efterpi Pavlidou, Matteo Bizzotto, Yunan Gao, Dario Balestra, Nicholas D Mazarakis

Neurol Genet· April 2022

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Viral Vector Delivery of DREADDs for CNS Therapy.
Ceri A Pickering, Nicholas D Mazarakis

Curr Gene Ther· November 2021

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Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration.
Lynn van Olst, Carla Rodriguez-Mogeda, Carmen Picon, Svenja Kiljan, Rachel E James, Nicholas D Mazarakis

Acta Neuropathol· June 2021

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Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.
Carmen Picon, Anusha Jayaraman, Rachel James, Catriona Beck, Patricia Gallego, Nicholas D Mazarakis

Acta Neuropathol· April 2021

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Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.
Patricia Gallego-Delgado, Rachel James, Eleanor Browne, Joanna Meng, Swetha Umashankar, Nicholas D Mazarakis

PLoS Biol· December 2020

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Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.
Paolo La Montanara, Arnau Hervera, Lucas L Baltussen, Thomas H Hutson, Ilaria Palmisano, Nicholas D Mazarakis

Sci Transl Med· July 2020

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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration.
Rachel E James, Renee Schalks, Eleanor Browne, Ioanna Eleftheriadou, Carmen Picon Munoz, Nicholas D Mazarakis

Acta Neuropathol Commun· May 2020

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Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder.
Yunan Gao, Elaine E Irvine, Ioanna Eleftheriadou, Carlos Jiménez Naranjo, Francesca Hearn-Yeates, Nicholas D Mazarakis

Brain· March 2020

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The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case of Childhood-Onset Movement Disorder.
Matthew Benger, Kshitij Mankad, Christos Proukakis, Nicholas D Mazarakis, Maria Kinali

Front Neurol· May 2019

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Autism spectrum disorder: prospects for treatment using gene therapy.
Matthew Benger, Maria Kinali, Nicholas D Mazarakis

Mol Autism· October 2018

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Selective transduction of astrocytic and neuronal CNS subpopulations by lentiviral vectors pseudotyped with Chikungunya virus envelope.
Ioanna Eleftheriadou, Michael Dieringer, Xuan Ying Poh, Julia Sanchez-Garrido, Yunan Gao, Nicholas D Mazarakis

Biomaterials· April 2017

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CAR IGF-1 vector targeting of motor neurons ameliorates disease progression in ALS mice.
Ioanna Eleftheriadou, Ioannis Manolaras, Elaine E Irvine, Michael Dieringer, Antonio Trabalza, Nicholas D Mazarakis

Ann Clin Transl Neurol· October 2016

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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Loukia Katsouri, Yau M Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Nicholas D Mazarakis

Proc Natl Acad Sci U S A· October 2016

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IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention.
Evangelos Pazarentzos, Anne-Laure Mahul-Mellier, Christoph Datler, Wanwisa Chaisaklert, Ming-Shih Hwang, Nicholas D Mazarakis

EMBO J· December 2014

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Anticancer gene transfer for cancer gene therapy.
Evangelos Pazarentzos, Nicholas D Mazarakis

Adv Exp Med Biol· November 2014

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Rabies virus envelope glycoprotein targets lentiviral vectors to the axonal retrograde pathway in motor neurons.
James N Hislop, Tarin A Islam, Ioanna Eleftheriadou, David C J Carpentier, Antonio Trabalza, Nicholas D Mazarakis

J Biol Chem· June 2014

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Enhanced central nervous system transduction with lentiviral vectors pseudotyped with RVG/HIV-1gp41 chimeric envelope glycoproteins.
Antonio Trabalza, Ioanna Eleftheriadou, Argyro Sgourou, Ting-Yi Liao, Petros Patsali, Nicholas D Mazarakis

J Virol· March 2014

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Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Stéphane Palfi, Jean Marc Gurruchaga, G Scott Ralph, Helene Lepetit, Sonia Lavisse, Nicholas D Mazarakis

Lancet· March 2014

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Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors.
Daniel M Lipinski, Alun R Barnard, Peter Charbel Issa, Mandeep S Singh, Samantha R De Silva, Nicholas D Mazarakis

Hum Gene Ther· January 2014

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Dose-dependent neuroprotection of VEGF₁₆₅ in Huntington's disease striatum.
Stuart M Ellison, Antonio Trabalza, Veronica Tisato, Evangelos Pazarentzos, Shirley Lee, Nicholas D Mazarakis

Mol Ther· October 2013

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Dual systemic tumor targeting with ligand-directed phage and Grp78 promoter induces tumor regression.
Azadeh Kia, Justyna M Przystal, Nastasia Nianiaris, Nicholas D Mazarakis, Paul J Mintz

Mol Cancer Ther· December 2012

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Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
John Mitchell, Praveen Paul, Han-Jou Chen, Alex Morris, Miles Payling, Nicholas D Mazarakis

Proc Natl Acad Sci U S A· April 2010

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Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.
Béchir Jarraya, Sabrina Boulet, G Scott Ralph, Caroline Jan, Gilles Bonvento, Nicholas D Mazarakis

Sci Transl Med· October 2009

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