Publications by authors named "Nicholas Ede"

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Novel Chimeric CTLA-4 B-cell Epitope Peptide Vaccines Demonstrate Effective Antitumor Immunity with/without PD1/PDL1 Blockade in Multiple Syngeneic Murine Models of Breast and Colorectal Cancers.
Linlin Guo, Jay Overholser, Sarah Naylon, Stephane Roche, Nicholas Ede

Mol Cancer Ther· September 2025

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Phase II Trial of HER-Vaxx, a B-cell Peptide-Based Vaccine, in HER2-Overexpressing Advanced Gastric Cancer Patients Under Platinum-Based Chemotherapy (HERIZON).
Joshua Tobias, Marina Maglakelidze, Zoran Andrić, Dinara Ryspayeva, Iurie Bulat, Nicholas J Ede, Ursula Wiedermann

Clin Cancer Res· September 2024

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Preclinical and Clinical Observations Implying Combination Therapy to Enhance the Efficacy of the Her-2/neu B-Cell Peptide-Based Vaccine HER-Vaxx and to Prevent Immune Evasion.
Joshua Tobias, Sandra Högler, Martin Raigel, Diego Shih-Chieh Lin, Yee Chao, Nicholas J Ede, Ursula Wiedermann

Int J Mol Sci· December 2023

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CF33-hNIS-anti-PD-L1 oncolytic virus followed by trastuzumab-deruxtecan in a patient with metastatic triple negative breast cancer: a case study.
Yuan Yuan, Colt Egelston, Oscar Colunga Flores, Shyambabu Chaurasiya, David Lin, Nicholas Ede

Ther Adv Med Oncol· November 2023

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An Oncolytic Poxvirus Encoding hNIS, Shows Antitumor Efficacy and Allows Tumor Imaging in a Liver Cancer Model.
Shyambabu Chaurasiya, Hannah Valencia, Zhifang Zhang, Sang-In Kim, Annie Yang, Nicholas J Ede

Mol Cancer Ther· June 2023

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An oncolytic poxvirus encoding hNIS, shows anti-tumor efficacy and allows tumor imaging in a liver cancer model.
Shyambabu Chaurasiya, Hannah Valencia, Zhifang Zhang, Sang-In Kim, Annie Yang, Nicholas J Ede

Mol Cancer Ther· May 2023

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Development of the B cell cancer vaccine HER-vaxx for the treatment of her-2 expressing cancers.
Nicholas J Ede, Anthony J Good, Joshua Tobias, Erika Garner-Spitzer, Christoph C Zielinski, Ursula Wiedermann

Front Oncol· December 2022

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A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx).
Linlin Guo, Jay Overholser, Heather Darby, Nicholas J Ede, Pravin T P Kaumaya

Oncoimmunology· October 2022

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Preclinical Studies of a Novel Human PD-1 B-Cell Peptide Cancer Vaccine PD1-Vaxx From BALB/c Mice to Beagle Dogs and to Non-Human Primates (Cynomolgus Monkeys).
Linlin Guo, Jay Overholser, Anthony J Good, Nicholas J Ede, Pravin T P Kaumaya

Front Oncol· May 2022

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A comprehensive preclinical study supporting clinical trial of oncolytic chimeric poxvirus CF33-hNIS-anti-PD-L1 to treat breast cancer.
Shyambabu Chaurasiya, Annie Yang, Zhifang Zhang, Jianming Lu, Hannah Valencia, Nicholas Ede

Mol Ther Methods Clin Dev· March 2022

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Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer-Results from Phase Ib Trial IMU.ACS.001.
Ursula Wiedermann, Erika Garner-Spitzer, Yee Chao, Marina Maglakelidze, Iurie Bulat, Nicholas J Ede

Clin Cancer Res· July 2021

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Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide.
Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Ursula Wiedermann

BMC Cancer· February 2017

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Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease.
Nicholas J Ede, Jeffrey Hill, Joma K Joy, Anne-Marie Ede, Merran L Koppens

J Pept Sci· November 2012

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Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
David I Rhodes, Thomas S Peat, Nick Vandegraaff, Dharshini Jeevarajah, Janet Newman, Nicholas J Ede

Chembiochem· October 2011

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Examination of methodology for the synthesis of cyclic thioether peptide libraries derived from linear tripeptides.
Kade D Roberts, Nicholas J Ede

J Pept Sci· December 2007

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Efficient methodology for the cyclization of linear peptide libraries via intramolecular S-alkylation using Multipin solid phase peptide synthesis.
Kade D Roberts, John N Lambert, Nicholas J Ede, Andrew M Bray

J Pept Sci· August 2006

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A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates.
Daniel A Thomas, Peter Francis, Carla Smith, Steven Ratcliffe, Nicholas J Ede

Proteomics· April 2006

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Preparation of cyclic peptide libraries using intramolecular oxime formation.
Kade D Roberts, John N Lambert, Nicholas J Ede, Andrew M Bray

J Pept Sci· November 2004

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Novel solid-phase synthesis of 1,2-dialkoxyindoles.
Zemin Wu, Nicholas J Ede

Org Lett· August 2003

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Beyond Rf tagging.
Nicholas J Ede, Zemin Wu

Curr Opin Chem Biol· June 2003

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Synthesis of tetrahydro-1,4-benzodiazepine-2-ones on hydrophilic polyamide SynPhase lanterns.
Zemin Wu, Francesca Ercole, Michael FitzGerald, Senake Perera, Phil Riley, Nicholas J Ede

J Comb Chem· May 2003

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Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes.
Yazhong Pei, Michael J Lilly, David J Owen, Lawrence J D'Souza, Xiao-Qing Tang, Nicholas J Ede

J Org Chem· January 2003

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Multiple parallel synthesis of peptides on SynPhase grafted supports.
Nicholas J Ede

J Immunol Methods· September 2002

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Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus.
Georgia Deliyannis, David C Jackson, Nicholas J Ede, Weiguang Zeng, Irene Hourdakis

J Virol· May 2002

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