Publications by authors named "Nicholas Hughes"

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Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes.
Yuning J Tang, Haiqing Xu, Nicholas W Hughes, Paloma Ruiz, Samuel H Kim

Cancer Discov· December 2025

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Efficient and multiplexed somatic genome editing with Cas12a mice.
Jess D Hebert, Haiqing Xu, Yuning J Tang, Paloma A Ruiz, Colin R Detrick, Nicholas W Hughes

Nat Biomed Eng· November 2025

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Computationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells.
Julia Marsiglia, Kia Vaalavirta, Estefany Knight, Muneaki Nakamura, Le Cong, Nicholas W Hughes

Cell Rep Methods· October 2024

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Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.
Yuning J Tang, Haiqing Xu, Nicholas W Hughes, Samuel H Kim, Paloma Ruiz

bioRxiv· August 2024

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Efficient and multiplexed somatic genome editing with Cas12a mice.
Jess D Hebert, Haiqing Xu, Yuning J Tang, Paloma A Ruiz, Colin R Detrick, Nicholas W Hughes

bioRxiv· May 2024

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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth.
Rui Tang, Emily G Shuldiner, Marcus Kelly, Christopher W Murray, Jess D Hebert, Nicholas W Hughes

Nat Cell Biol· January 2023

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Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles.
Nicholas W Hughes, Yuanhao Qu, Jiaqi Zhang, Weijing Tang, Justin Pierce

Mol Cell· August 2022

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CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells.
Chengkun Wang, Qiong Xia, Qianhe Zhang, Yuanhao Qu, Stephen Su, Nicholas W Hughes

Front Cell Dev Biol· June 2022

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dCas9-based gene editing for cleavage-free genomic knock-in of long sequences.
Chengkun Wang, Yuanhao Qu, Jason K W Cheng, Nicholas W Hughes, Qianhe Zhang

Nat Cell Biol· February 2022

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A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.
Hongchen Cai, Su Kit Chew, Chuan Li, Min K Tsai, Laura Andrejka, Nicholas W Hughes

Cancer Discov· July 2021

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Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects.
Chengkun Wang, Jason K W Cheng, Qianhe Zhang, Nicholas W Hughes, Qiong Xia

Nucleic Acids Res· April 2021

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A CRISPR Landing for Genome Rewriting at Locus-Scale.
Nicholas W Hughes, Le Cong

CRISPR J· April 2021

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Diagnostic difficulties in a patient with multiple sclerosis who presents with cranial nerve palsies: an unusual complication of dental work.
Jennifer Cathcart, Rebecca Caitlin Johnson, Nicholas Hughes, Manish Patel

BMJ Case Rep· October 2020

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Health information work and the enactment of care in couples and families affected by Multiple Sclerosis.
Fadhila Mazanderani, Nicholas Hughes, Claire Hardy, Elizabeth Sillence, John Powell

Sociol Health Illn· February 2019

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A blood biomarker for monitoring response to anti-EGFR therapy.
Nicholas P Hughes, Lingyun Xu, Carsten H Nielsen, Edwin Chang, Sharon S Hori

Cancer Biomark· October 2018

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Navigating an unfamiliar world: how parents of young people who self-harm experience support and treatment.
Anne Stewart, Nicholas D Hughes, Sue Simkin, Louise Locock, Anne Ferrey

Child Adolesc Ment Health· May 2018

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Improving the management of pain from advanced cancer in the community: study protocol for a pragmatic multicentre randomised controlled trial.
Matthew J Allsop, Alexandra Wright-Hughes, Kath Black, Suzanne Hartley, Marie Fletcher, Nicholas D Hughes

BMJ Open· March 2018

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Estimating Cortical Feature Maps with Dependent Gaussian Processes.
Nicholas J Hughes, Geoffrey J Goodhill

IEEE Trans Pattern Anal Mach Intell· October 2017

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Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location.
Marta Vilalta, Nicholas P Hughes, Rie Von Eyben, Amato J Giaccia, Edward E Graves

Mol Imaging Biol· April 2017

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Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Tim Wang, Haiyan Yu, Nicholas W Hughes, Bingxu Liu, Arek Kendirli

Cell· February 2017

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Supporting self-management of pain by patients with advanced cancer: views of palliative care professionals.
Nicholas D Hughes, S José Closs, Kate Flemming, Michael I Bennett

Support Care Cancer· December 2016

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Changes in parenting strategies after a young person's self-harm: a qualitative study.
Anne E Ferrey, Nicholas D Hughes, Sue Simkin, Louise Locock, Anne Stewart

Child Adolesc Psychiatry Ment Health· July 2016

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Sensory experience modifies feature map relationships in visual cortex.
Shaun L Cloherty, Nicholas J Hughes, Markus A Hietanen, Partha S Bhagavatula, Geoffrey J Goodhill

Elife· June 2016

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Limitations of Neural Map Topography for Decoding Spatial Information.
Lilach Avitan, Zac Pujic, Nicholas J Hughes, Ethan K Scott, Geoffrey J Goodhill

J Neurosci· May 2016

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