Publications by authors named "Nicholas Izzo"

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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Nicholas J Izzo

Acta Neuropathol· February 2024

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A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer's disease using an indwelling CSF catheter.
Kelsie M LaBarbera, Yvette I Sheline, Nicholas J Izzo, Carla M Yuede, Lora Waybright

Transl Neurodegener· May 2023

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Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands.
Kuiying Xu, Chia-Ju Hsieh, Ji Youn Lee, Aladdin Riad, Nicholas J Izzo

Int J Mol Sci· July 2022

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Screening of σ Receptor Ligands and Evaluation of C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ Receptor Brain PET Tracer.
Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Aladdin Riad, Nicholas J Izzo

J Med Chem· April 2022

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Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Gilbert M Rishton, Gary C Look, Zhi-Jie Ni, Jason Zhang, Yingcai Wang, Nicholas J Izzo

ACS Med Chem Lett· September 2021

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Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Nicholas J Izzo, Carla M Yuede, Kelsie M LaBarbera, Colleen S Limegrover, Courtney Rehak

Alzheimers Dement· August 2021

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Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery.
Kelsie Mozzoni LaBarbera, Colleen Limegrover, Courtney Rehak, Raymond Yurko, Nicholas John Izzo

J Neurosci Methods· July 2021

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Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.
Nicholas J Izzo, Martí Colom-Cadena, Aladdin A Riad, Jinbin Xu, Meharvan Singh

eNeuro· June 2021

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Alzheimer's protection effect of A673T mutation may be driven by lower Aβ oligomer binding affinity.
Colleen S Limegrover, Harry LeVine, Nicholas J Izzo, Raymond Yurko, Kelsie Mozzoni

J Neurochem· May 2021

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Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.
Colleen S Limegrover, Raymond Yurko, Nicholas J Izzo, Kelsie M LaBarbera, Courtney Rehak

J Neurosci Res· April 2021

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The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease.
Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Nicholas J Izzo

Alzheimers Res Ther· March 2020

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A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease.
Michael Grundman, Roger Morgan, Jason D Lickliter, Lon S Schneider, Steven DeKosky, Nicholas J Izzo

Alzheimers Dement (N Y)· January 2019

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Nicholas J Izzo, Agnes Staniszewski, Lillian To, Mauro Fa, Andrew F Teich

PLoS One· July 2015

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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
Nicholas J Izzo, Jinbin Xu, Chenbo Zeng, Molly J Kirk, Kelsie Mozzoni

PLoS One· July 2015

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Sustained hypoxia enhances chondrocyte matrix synthesis.
Christian H Coyle, Nicholas J Izzo, Constance R Chu

J Orthop Res· June 2009

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Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage.
Brian N Dontchos, Christian H Coyle, Nicholas J Izzo, Deanna M Didiano, John C Karpie

J Orthop Res· May 2008

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Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography.
Constance R Chu, Nicholas J Izzo, James J Irrgang, Mario Ferretti, Rebecca K Studer

J Biomed Opt· January 2008

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In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes.
Constance R Chu, Nicholas J Izzo, Nicole E Papas, Freddie H Fu

Arthroscopy· July 2006

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Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogels.
Alicia J DeFail, Constance R Chu, Nicholas Izzo, Kacey G Marra

Biomaterials· March 2006

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Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasis.
Peter U Brucker, Nicholas J Izzo, Constance R Chu

Arthritis Rheum· October 2005

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Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures.
Koichiro Kawamura, Constance R Chu, Satoshi Sobajima, Paul D Robbins, Freddie H Fu, Nicholas J Izzo

Exp Hematol· August 2005

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Determination of endogenous extracellular signal-regulated protein kinase by microchip capillary electrophoresis.
Dustin E Starkey, Yasser Abdelaziez, Chong H Ahn, Jian Tu, LaShonda Anderson, Nicholas J Izzo

Anal Biochem· May 2003

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