Publications by authors named "Nicholas Laping"

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Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy.
Shon A Koren, Matthew J Hamm, Ryan Cloyd, Sarah N Fontaine, Emad Chishti, Nicholas J Laping

Int J Mol Sci· January 2021

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Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function.
Zehua Bian, Qiang Wang, Xinyu Zhou, Tao Tan, Ki Ho Park, Nicholas J Laping

Nat Commun· October 2019

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PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
Valentina Grande, Francesca Ornaghi, Liliana Comerio, Elena Restelli, Antonio Masone, Nicholas J Laping

Hum Mol Genet· July 2018

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TLR2 agonism reverses chemotherapy-induced neutropenia in .
Nicholas J Laping, Michael P DeMartino, Joshua E Cottom, Jeffrey M Axten, John G Emery

Blood Adv· December 2017

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Effects of Rho-kinase inhibition on myosin light chain phosphorylation and obstruction-induced detrusor overactivity.
James O Marx, Maureen E Basha, Sunish Mohanan, Joseph A Hypolite, Shaohua Chang, Nicholas J Laping

Int J Urol· March 2014

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Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
Angela K Clouse, Malcolm J Jugus, Stephen H Eisennagel, Nicholas J Laping, Timothy D Westfall

Urology· June 2012

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Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists.
Jian Jin, Angel Morales-Ramos, Patrick Eidam, John Mecom, Yue Li, Nicholas Laping

ACS Med Chem Lett· October 2010

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Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor alpha in rat uterine cells and tissues.
Lindsay Glace, Eugene T Grygielko, Ryan Boyle, Qi Wang, Nicholas J Laping

Steroids· February 2010

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Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
Lara S Kallander, David G Washburn, Tram H Hoang, James S Frazee, Patrick Stoy, Nicholas J Laping

Bioorg Med Chem Lett· January 2010

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Evaluation of pressor and visceromotor reflex responses to bladder distension in urethane anesthetized rats.
Lauren K Blatt, Erin S R Lashinger, Nicholas J Laping, Xin Su

Neurourol Urodyn· September 2009

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Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Marlys Hammond, David G Washburn, H Tram Hoang, Sharada Manns, James S Frazee, Nicholas J Laping

Bioorg Med Chem Lett· August 2009

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Effect of estrogen and progesterone on urodynamics in the conscious rat.
Phani B Patra, Kevin S Thorneloe, Nicholas J Laping

Urology· August 2009

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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
Scott K Thompson, David G Washburn, James S Frazee, Kevin P Madauss, Tram H Hoang, Nicholas J Laping

Bioorg Med Chem Lett· August 2009

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Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists.
Marlys Hammond, Jaclyn R Patterson, Sharada Manns, Tram H Hoang, David G Washburn, Nicholas J Laping

Bioorg Med Chem Lett· May 2009

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Urodynamic measurements by radiotelemetry in conscious, freely moving beagle dogs.
Gerald P McCafferty, Robert W Coatney, Nicholas J Laping, Kevin S Thorneloe

J Urol· March 2009

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Modulation of bladder function by prostaglandin EP3 receptors in the central nervous system.
Xin Su, Lisa A Leon, Charlene W Wu, Dwight M Morrow, Jon-Paul Jaworski, Nicholas J Laping

Am J Physiol Renal Physiol· October 2008

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AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.
Erin S R Lashinger, Matthew S Steiginga, J Paul Hieble, Lisa A Leon, Scott D Gardner, Nicholas J Laping

Am J Physiol Renal Physiol· September 2008

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Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.
Andrea B Sherk, Daniel E Frigo, Christine G Schnackenberg, Jeffrey D Bray, Nicholas J Laping

Cancer Res· September 2008

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N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.
Kevin S Thorneloe, Anthony C Sulpizio, Zuojun Lin, David J Figueroa, Angela K Clouse, Nicholas J Laping

J Pharmacol Exp Ther· August 2008

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Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice.
Gerald P McCafferty, Blake A Misajet, Nicholas J Laping, Richard M Edwards, Kevin S Thorneloe

Am J Physiol Renal Physiol· August 2008

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An excitatory role for peripheral EP3 receptors in bladder afferent function.
Xin Su, Erin S R Lashinger, Lisa A Leon, Bryan E Hoffman, J Paul Hieble, Nicholas J Laping

Am J Physiol Renal Physiol· August 2008

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Effects of the beta 3-adrenergic receptor agonist disodium 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on bladder micturition reflex in spontaneously hypertensive rats.
Lisa A Leon, Bryan E Hoffman, Scott D Gardner, Nicholas J Laping, Christopher Evans

J Pharmacol Exp Ther· July 2008

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Role of spinal Cav2.2 and Cav2.1 ion channels in bladder nociception.
Xin Su, Lisa A Leon, Nicholas J Laping

J Urol· June 2008

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Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Xin Su, Erin S Riedel, Lisa A Leon, Nicholas J Laping

Neurourol Urodyn· May 2008

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Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.
Amy Wang, Fuad N Ziyadeh, Eun Young Lee, Petr E Pyagay, Sun Hee Sung, Nicholas J Laping

Am J Physiol Renal Physiol· November 2007

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