Publications by authors named "Nicholas N Lyssenko"

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Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE.
Viktor Garliyev, Catherine A Lyssenko, Joel P Wiener, Domenico Praticò, Nicholas N Lyssenko

J Neuropathol Exp Neurol· October 2024

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Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA.
Joel P Wiener, Sindy Desire, Viktor Garliyev, Nicholas Lyssenko Iii, Domenico Praticò, Nicholas N Lyssenko

Cells· August 2023

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ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease.
Yi-An Ko, Jeffrey T Billheimer, Nicholas N Lyssenko, Alexandra Kueider-Paisley, David A Wolk

Alzheimers Res Ther· December 2022

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The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.
Nicholas N Lyssenko, Xinghua Shi, Domenico Praticò

Acta Neuropathol· September 2022

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Specificity of ABCA7-mediated cell lipid efflux.
Antonino Picataggi, Amrith Rodrigues, Debra A Cromley, Hu Wang, Joel P Wiener, Nicholas N Lyssenko

Biochim Biophys Acta Mol Cell Biol Lipids· July 2022

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Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease.
Eleonora Cipollari, Hannah J Szapary, Antonino Picataggi, Jeffrey T Billheimer, Catherine A Lyssenko, Nicholas N Lyssenko

J Alzheimers Dis· August 2021

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ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease.
Nicholas N Lyssenko, Domenico Praticò

Alzheimers Dement· February 2021

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Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics.
Makan Khoshnejad, Ami Patel, Krzysztof Wojtak, Sagar B Kudchodkar, Laurent Humeau, Nicholas N Lyssenko

Mol Ther· January 2019

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Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.
Nicholas N Lyssenko, Naqi Haider, Antonino Picataggi, Eleonora Cipollari, Wanzhen Jiao

J Lipid Res· October 2018

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Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.
Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R Lagor, Nicholas N Lyssenko

J Lipid Res· April 2017

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ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion.
Xin Bi, Evanthia E Pashos, Marina Cuchel, Nicholas N Lyssenko, Mayda Hernandez

EBioMedicine· April 2017

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Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.
Duyen Quach, Cecilia Vitali, Fiona M La, Angel X Xiao, John S Millar, Nicholas N Lyssenko

Biochim Biophys Acta· December 2016

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Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein.
Andrea J Luthi, Nicholas N Lyssenko, Duyen Quach, Kaylin M McMahon, John S Millar

J Lipid Res· May 2015

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Mechanisms responsible for the compositional heterogeneity of nascent high density lipoprotein.
Sissel Lund-Katz, Nicholas N Lyssenko, Margaret Nickel, David Nguyen, Palaniappan Sevugan Chetty

J Biol Chem· August 2013

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Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.
Nicholas N Lyssenko, Margaret Nickel, Chongren Tang, Michael C Phillips

FASEB J· July 2013

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Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality.
Nicholas N Lyssenko, Mami Hata, Padmaja Dhanasekaran, Margaret Nickel, David Nguyen

Biochim Biophys Acta· March 2012

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A novel compound inhibits reconstituted high-density lipoprotein assembly and blocks nascent high-density lipoprotein biogenesis downstream of apolipoprotein AI binding to ATP-binding cassette transporter A1-expressing cells.
Nicholas N Lyssenko, Gregory Brubaker, Bradley D Smith, Jonathan D Smith

Arterioscler Thromb Vasc Biol· November 2011

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An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases.
Nicholas N Lyssenko, Yana Miteva, Simon Gilroy, Wendy Hanna-Rose, Robert A Schlegel

BMC Dev Biol· October 2008

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Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans.
Nicholas N Lyssenko, Wendy Hanna-Rose, Robert A Schlegel

Biotechniques· November 2007

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Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis.
Stephanie Züllig, Lukas J Neukomm, Marko Jovanovic, Steve J Charette, Nicholas N Lyssenko

Curr Biol· June 2007

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The Arabidopsis repressor of light signaling, COP1, is regulated by nuclear exclusion: mutational analysis by bioluminescence resonance energy transfer.
Chitra Subramanian, Byung-Hoon Kim, Nicholas N Lyssenko, Xiaodong Xu, Carl Hirschie Johnson

Proc Natl Acad Sci U S A· April 2004

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Functional analysis of regulatory elements in the gene promoter for an abscission-specific cellulase from bean and isolation, expression, and binding affinity of three TGA-type basic leucine zipper transcription factors.
Mark L Tucker, Catherine A Whitelaw, Nicholas N Lyssenko, Pravendra Nath

Plant Physiol· November 2002

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Delayed abscission and shorter Internodes correlate with a reduction in the ethylene receptor LeETR1 transcript in transgenic tomato.
Catherine A Whitelaw, Nicholas N Lyssenko, Liwei Chen, Dingbo Zhou, Autar K Mattoo

Plant Physiol· March 2002

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