Publications by authors named "Niels Vrang"

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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.
Jens Christian Nielsen, Claudia Hjo Rringgaard, Mads Mo Rup Nygaard, Anita Wester, Lisbeth Elster, Niels Vrang

J Med Chem· July 2024

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Identification of GDF15 peptide fragments inhibiting GFRAL receptor signaling.
Flora Alexopoulou, Nina Buch-Månson, Søren Ljungberg Pedersen, Niels Vrang, Lisbeth Nielsen Fink

Peptides· October 2023

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Hepatoprotective effects of the long-acting fibroblast growth factor 21 analog PF-05231023 in the GAN diet-induced obese and biopsy-confirmed mouse model of nonalcoholic steatohepatitis.
Malte Hasle Nielsen, Matthew P Gillum, Niels Vrang, Jacob Jelsing, Henrik H Hansen

Am J Physiol Gastrointest Liver Physiol· May 2023

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Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH.
Mathias B Møllerhøj, Sanne S Veidal, Kirstine Tølbøl Thrane, Denise Oró, Agnete Overgaard, Niels Vrang

Clin Transl Sci· May 2022

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Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect.
Flora Alexopoulou, Esben Matzen Bech, Søren Ljungberg Pedersen, Ditte Dencker Thorbek, Ulrike Leurs, Niels Vrang

Sci Rep· February 2022

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Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease.
Frederikke E Sembach, Helene M Ægidius, Lisbeth N Fink, Thomas Secher, Annemarie Aarup, Niels Vrang

Dis Model Mech· October 2021

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Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease.
Mette V Østergaard, Thomas Secher, Michael Christensen, Casper Gravesen Salinas, Urmas Roostalu, Niels Vrang

Am J Physiol Renal Physiol· August 2021

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An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy.
Johanna Perens, Casper Gravesen Salinas, Jacob Lercke Skytte, Urmas Roostalu, Anders Bjorholm Dahl, Niels Vrang

Neuroinformatics· July 2021

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Whole-brain activation signatures of weight-lowering drugs.
Henrik H Hansen, Johanna Perens, Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Niels Vrang

Mol Metab· May 2021

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Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice.
Henrik H Hansen, Rikke V Grønlund, Tamara Baader-Pagler, Peter Haebel, Harald Tammen, Niels Vrang

Sci Rep· April 2021

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Whole-brain mapping of amylin-induced neuronal activity in receptor activity-modifying protein 1/3 knockout mice.
Grethe Skovbjerg, Urmas Roostalu, Henrik H Hansen, Thomas A Lutz, Christelle Le Foll, Niels Vrang

Eur J Neurosci· April 2021

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Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography.
Urmas Roostalu, Louise Thisted, Jacob Lercke Skytte, Casper Gravesen Salinas, Philip Juhl Pedersen, Niels Vrang

Sci Rep· March 2021

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An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins.
Karin Mannerstedt, Narendra Kumar Mishra, Ebbe Engholm, Morten Lundh, Charlotte S Madsen, Niels Vrang

Chemistry· February 2021

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Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model.
Chen Zhang, Lise Christine Biehl Rudkjær, Marisa Fernández Cachón, Mechthilde Falkenhahn, Stefan Theis, Niels Vrang

Peptides· February 2021

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Rodent models of diabetic kidney disease: human translatability and preclinical validity.
Frederikke E Sembach, Mette V Østergaard, Niels Vrang, Bo Feldt-Rasmussen, Keld Fosgerau

Drug Discov Today· January 2021

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Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment.
Christoffer A Hagemann, Chen Zhang, Henrik H Hansen, Tina Jorsal, Kristoffer T G Rigbolt, Niels Vrang

J Clin Endocrinol Metab· January 2021

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Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in diabetic db/db mice.
Mette Simone Aae Madsen, Rikke Veggerby Grønlund, John Eid, Mikkel Christensen-Dalsgaard, Morten Sommer, Niels Vrang

Biomed Pharmacother· January 2021

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3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II.
Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang

Dis Model Mech· December 2020

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Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery.
Tina Jorsal, Marie M Christensen, Brynjulf Mortensen, Eva B Nygaard, Chen Zhang, Niels Vrang

Obesity (Silver Spring)· November 2020

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Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.
Henrik H Hansen, Helene M Ægidius, Denise Oró, Simon S Evers, Sara Heebøll, Niels Vrang

BMC Gastroenterol· July 2020

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Automated Image Analyses of Glomerular Hypertrophy in a Mouse Model of Diabetic Nephropathy.
Mette V Østergaard, Frederikke E Sembach, Jacob L Skytte, Urmas Roostalu, Thomas Secher, Niels Vrang

Kidney360· June 2020

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The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity.
Chen Zhang, Pernille Barkholt, Jens Christian Nielsen, Ditte Dencker Thorbek, Kristoffer Rigbolt, Niels Vrang

Brain Res· January 2020

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Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis.
Helene M Ægidius, Sanne S Veidal, Michael Feigh, Philip Hallenborg, Michele Puglia, Niels Vrang

Sci Rep· January 2020

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Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice.
Frederikke E Sembach, Lisbeth N Fink, Thea Johansen, Brandon B Boland, Thomas Secher, Niels Vrang

Physiol Rep· December 2019

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Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH.
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Christina Christoffersen, Michael Feigh, Niels Vrang

BMC Gastroenterol· December 2019

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