Publications by authors named "Nigel Irwin"

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Impact of novel amino acid substituted and acylated spexin analogues on pancreatic beta-cell function, appetite and glucose homeostasis.
Daniel M Gallagher, Md Zahidul Islam Khan, Steven Patterson, Finbarr P M O'Harte, Nigel Irwin

Mol Cell Endocrinol· November 2025

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Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.
Ananyaa Sridhar, Dawood Khan, Rithiga Muthukumar, Swetha Sampathkumar, Nigel Irwin

Biomolecules· November 2025

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Effect of Multiparity on Pregnancy-Induced Islet Adaptation and Cellular Transdifferentiation.
Vaibhav Dubey, Neil Tanday, Asif Ali, Andrei I Tarasov, Peter R Flatt, Nigel Irwin

Clin Med Insights Endocrinol Diabetes· October 2025

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The Beneficial Impact of a Novel Pancreatic Polypeptide Analogue on Islet Cell Lineage.
Wuyun Zhu, Neil Tanday, Peter R Flatt, Nigel Irwin

Int J Mol Sci· April 2025

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Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy.
Vaibhav Dubey, Neil Tanday, Nigel Irwin, Andrei I Tarasov, Peter R Flatt

Diabet Med· January 2025

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Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice.
Wuyun Zhu, Neil Tanday, Ryan A Lafferty, Peter R Flatt, Nigel Irwin

Biofactors· December 2024

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[P]PP, a stable, long-acting pancreatic polypeptide analogue, evokes weight lowering and pancreatic beta-cell-protective effects in obesity-associated diabetes.
Neil Tanday, Wuyun Zhu, Andrei I Tarasov, Peter R Flatt, Nigel Irwin

Diabetes Obes Metab· November 2024

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Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.
Asif Ali, Dawood Khan, Vaibhav Dubey, Andrei I Tarasov, Peter R Flatt, Nigel Irwin

Biomolecules· November 2024

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NPYR modulation: Potential for the next major advance in obesity and type 2 diabetes management?
Ryan A Lafferty, Peter R Flatt, Nigel Irwin

Peptides· September 2024

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Chronic exposure to incretin metabolites GLP-1(9-36) and GIP(3-42) affect islet morphology and beta cell health in high fat fed mice.
Ananyaa Sridhar, Dawood Khan, Gayathri Babu, Nigel Irwin, Victor A Gault

Peptides· August 2024

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Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?
Ryan A Lafferty, Peter R Flatt, Victor A Gault, Nigel Irwin

J Endocrinol· August 2024

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Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress.
Ananyaa Sridhar, Peter R Flatt, Matthew Draper, Andrei I Tarasov, R Charlotte Moffett, Nigel Irwin

J Pharm Pharmacol· July 2024

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Gut-Derived Peptide Hormone Analogues and Potential Treatment of Bone Disorders in Obesity and Diabetes Mellitus.
Asif Ali, Peter R Flatt, Nigel Irwin

Clin Med Insights Endocrinol Diabetes· March 2024

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An update on galanin and spexin and their potential for the treatment of type 2 diabetes and related metabolic disorders.
Daniel M Gallagher, Finbarr P M O'Harte, Nigel Irwin

Peptides· January 2024

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Sustained metabolic benefits of ΔTRTX-Ac1, a tarantula venom-derived peptide, when administered together with exenatide in high-fat fed mice.
Aimee Coulter-Parkhill, Neil Tanday, Diego Cobice, Christopher M McLaughlin, Stephen McClean, Nigel Irwin

Diabetes Obes Metab· January 2024

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Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?
Neil Tanday, Andrei I Tarasov, R Charlotte Moffett, Peter R Flatt, Nigel Irwin

Diabetes Obes Metab· January 2024

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Sex-based impact of pancreatic islet stressors in GluCreERT2/Rosa26-eYFP mice.
Neil Tanday, Aimee Coulter-Parkhill, R Charlotte Moffett, Karthick Suruli, Vaibhav Dubey, Nigel Irwin

J Endocrinol· November 2023

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GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice.
Ananyaa Sridhar, Dawood Khan, Peter R Flatt, Charlotte R Moffett, Nigel Irwin

Peptides· November 2023

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The glucagon receptor antagonist desHisProGlu-glucagon(LysPAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.
Ryan Lafferty, Neil Tanday, Vaibhav Dubey, Aimee Coulter-Parkhill, Karthick Vishal, Nigel Irwin

Mol Cell Endocrinol· June 2023

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RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.
Ananyaa Sridhar, Dawood Khan, Jessie A Elliott, Violetta Naughton, Peter R Flatt, Nigel Irwin

PLoS One· June 2023

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Development of a First-in-Class Unimolecular Dual GIP/GLP-2 Analogue, GL-0001, for the Treatment of Bone Fragility.
Benoit Gobron, Malory Couchot, Nigel Irwin, Erick Legrand, Béatrice Bouvard

J Bone Miner Res· May 2023

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Have we got the guts to maintain target weight?
Nigel Irwin

Acta Physiol (Oxf)· May 2023

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GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy.
Ryan A Lafferty, Peter R Flatt, Nigel Irwin

Expert Opin Pharmacother· April 2023

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Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes.
Wuyun Zhu, Neil Tanday, Peter R Flatt, Nigel Irwin

Peptides· February 2023

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Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.
Dipak Sarnobat, Ryan A Lafferty, R Charlotte Moffett, Andrei I Tarasov, Peter R Flatt, Nigel Irwin

J Pharm Pharmacol· November 2022

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