Publications by authors named "Victor A Gault"

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Chronic exposure to incretin metabolites GLP-1(9-36) and GIP(3-42) affect islet morphology and beta cell health in high fat fed mice.
Ananyaa Sridhar, Dawood Khan, Gayathri Babu, Nigel Irwin, Victor A Gault

Peptides· August 2024

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Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?
Ryan A Lafferty, Peter R Flatt, Victor A Gault, Nigel Irwin

J Endocrinol· August 2024

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Sustained metabolic benefits of ΔTRTX-Ac1, a tarantula venom-derived peptide, when administered together with exenatide in high-fat fed mice.
Aimee Coulter-Parkhill, Neil Tanday, Diego Cobice, Christopher M McLaughlin, Stephen McClean, Victor A Gault

Diabetes Obes Metab· January 2024

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Proglucagon-Derived Peptides as Therapeutics.
Ryan A Lafferty, Finbarr P M O'Harte, Nigel Irwin, Victor A Gault, Peter R Flatt

Front Endocrinol (Lausanne)· December 2021

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Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.
Sarah L Craig, Nigel Irwin, Victor A Gault

Clin Med Insights Endocrinol Diabetes· September 2021

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A novel neurotensin/xenin fusion peptide enhances β-cell function and exhibits antidiabetic efficacy in high-fat fed mice.
Rachele A Perry, Sarah L Craig, Victor A Gault, Peter R Flatt, Nigel Irwin

Biosci Rep· August 2021

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Enzymatically stable analogue of the gut-derived peptide xenin on beta-cell transdifferentiation in high fat fed and insulin-deficient Ins1 ;Rosa26-eYFP mice.
Neil Tanday, R Charlotte Moffett, Victor A Gault, Peter R Flatt, Nigel Irwin

Diabetes Metab Res Rev· March 2021

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Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes.
Aimee Coulter-Parkhill, Stephen McClean, Victor A Gault, Nigel Irwin

Clin Med Insights Endocrinol Diabetes· March 2021

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The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin.
Sarah L Craig, Victor A Gault, Peter R Flatt, Nigel Irwin

Biochem Pharmacol· January 2021

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Dapagliflozin and Liraglutide Therapies Rapidly Enhanced Bone Material Properties and Matrix Biomechanics at Bone Formation Site in a Type 2 Diabetic Mouse Model.
Aleksandra Mieczkowska, Paul Millar, Daniel Chappard, Victor A Gault, Guillaume Mabilleau

Calcif Tissue Int· September 2020

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Ψ-Xenin-6 enhances sitagliptin effectiveness, but does not improve glucose tolerance.
Sarah L Craig, Victor A Gault, Gerd Hamscher, Nigel Irwin

J Endocrinol· May 2020

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Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes.
Nigel Irwin, Victor A Gault, Finbarr P M O'Harte, Peter R Flatt

Peptides· March 2020

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Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic Glu;ROSA26-eYFP mice.
Dipak Sarnobat, R Charlotte Moffett, Victor A Gault, Neil Tanday, Frank Reimann

Peptides· March 2020

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Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice.
Chao Ma, Jeroen H F de Baaij, Paul J Millar, Victor A Gault, Bastiaan E de Galan

Nephron· December 2019

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The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety.
Molly R Davies, Gursharan Kalsi, Chérie Armour, Ian R Jones, Andrew M McIntosh, Victor A Gault

Behav Res Ther· December 2019

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Effects of 2 Novel PYY(1-36) Analogues, (PLP)PYY(1-36) and PYY(1-36)(LysPAL), on Pancreatic Beta-Cell Function, Growth, and Survival.
Ryan A Lafferty, Victor A Gault, Peter R Flatt, Nigel Irwin

Clin Med Insights Endocrinol Diabetes· June 2019

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Exendin-4(Lys PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.
Annie Hasib, Ming T Ng, Neil Tanday, Sarah L Craig, Victor A Gault

Diabetes Metab Res Rev· March 2019

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Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.
Sarah L Craig, Victor A Gault, Nigel Irwin

Diabetes Metab Res Rev· September 2018

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Characterisation and antidiabetic utility of a novel hybrid peptide, exendin-4/gastrin/xenin-8-Gln.
Annie Hasib, Ming T Ng, Dawood Khan, Victor A Gault, Peter R Flatt

Eur J Pharmacol· September 2018

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Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model.
Paul Denver, Victor A Gault, Paula L McClean

Diabetes Obes Metab· May 2018

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Evaluation of the insulinotropic and glucose-lowering actions of zebrafish GIP in mammalian systems: Evidence for involvement of the GLP-1 receptor.
Galyna V Graham, J Michael Conlon, Yasser H Abdel-Wahab, Victor A Gault, Peter R Flatt

Peptides· February 2018

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GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes.
Victor A Gault, Christian Hölscher

Peptides· February 2018

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A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice.
Annie Hasib, Ming T Ng, Dawood Khan, Victor A Gault, Peter R Flatt

Peptides· February 2018

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Beneficial metabolic effects of dietary epigallocatechin gallate alone and in combination with exendin-4 in high fat diabetic mice.
Nupur M Pathak, Paul J B Millar, Varun Pathak, Peter R Flatt, Victor A Gault

Mol Cell Endocrinol· January 2018

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Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.
Dawood Khan, Srividya Vasu, R Charlotte Moffett, Victor A Gault, Peter R Flatt

Biol Chem· December 2017

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