Publications by authors named "Nigel Leigh"

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Stratifying IL-2 therapy in ALS: integrating biomarkers - Authors' reply.
Gilbert Bensimon, P Nigel Leigh, Timothy Tree

Lancet· November 2025

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Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.
Michele T Hu, Agustin Querejeta Coma, James B Rowe, Tanja Zerenner, Alistair Church, P Nigel Leigh

Brain· September 2025

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Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy.
Viorica Chelban, David Pellerin, Nirosen Vijiaratnam, Hamin Lee, Yen Yee Goh, P Nigel Leigh

Brain· September 2025

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Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study.
Christina D Orrú, David P Vaughan, Nirosen Vijiaratnam, Raquel Real, Alejandro Martinez-Carrasco, P Nigel Leigh

Lancet Neurol· July 2025

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Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial.
Gilbert Bensimon, P Nigel Leigh, Timothy Tree, Andrea Malaspina, Christine Am Payan

Lancet· May 2025

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Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome.
David P Vaughan, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Tatiana Georgiades, P Nigel Leigh

Mov Disord· December 2024

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Investigating the impact of socioeconomic status on amyotrophic lateral sclerosis.
Ali Shojaie, Ahmad Al Khleifat, Sarah Garrahy, Haniah Habash-Bailey, Rachel Thomson, P Nigel Leigh

Amyotroph Lateral Scler Frontotemporal Degener· November 2024

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Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.
Christopher Kobylecki, Viorica Chelban, Yee Yen Goh, Emilia Michou, Riona Fumi, P Nigel Leigh

Eur J Neurol· June 2024

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Pharmacometabolomics applied to low-dose interleukin-2 treatment in amyotrophic lateral sclerosis.
Hugo Alarcan, Clément Bruno, Patrick Emond, Cédric Raoul, Patrick Vourc'h, P Nigel Leigh

Ann N Y Acad Sci· June 2024

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Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials.
Duncan Street, Edwin Jabbari, Alyssa Costantini, P Simon Jones, Negin Holland, P Nigel Leigh

Brain· August 2023

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Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.
David J Whiteside, Duncan Street, Alexander G Murley, P Simon Jones, Maura Malpetti, P Nigel Leigh

Hum Brain Mapp· August 2023

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Comparison Of King's Clinical Staging In Multinational Amyotrophic Lateral Sclerosis Cohorts.
Rubika Balendra, Ashley R Jones, Ahmad Al Khleifat, Theresa Chiwera, Paul Wicks, P Nigel Leigh

Amyotroph Lateral Scler Frontotemporal Degener· February 2023

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Neurofilament light levels predict clinical progression and death in multiple system atrophy.
Viorica Chelban, Elham Nikram, Alexandra Perez-Soriano, Carlo Wilke, Alexandra Foubert-Samier, P Nigel Leigh

Brain· December 2022

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Profiling non-coding RNA expression in cerebrospinal fluid of amyotrophic lateral sclerosis patients.
Greig Joilin, Elizabeth Gray, Alexander G Thompson, Kevin Talbot, P Nigel Leigh

Ann Med· December 2022

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Potential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy.
Fabio A Simoes, Greig Joilin, Oliver Peters, Luisa-Sophie Schneider, Josef Priller, P Nigel Leigh

Int J Mol Sci· November 2022

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Altered network stability in progressive supranuclear palsy.
David J Whiteside, P Simon Jones, Boyd C P Ghosh, Ian Coyle-Gilchrist, Alexander Gerhard, P Nigel Leigh

Neurobiol Aging· November 2021

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Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.
Charis Wong, Maria Stavrou, Elizabeth Elliott, Jenna M Gregory, Nigel Leigh, Danielle Leighton

Brain Commun· October 2021

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Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2.
Ilaria Giovannelli, Nadhim Bayatti, Abigail Brown, Dennis Wang, Marius Mickunas, P Nigel Leigh

Brain Commun· June 2021

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Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial.
William Camu, Marius Mickunas, Jean-Luc Veyrune, Christine Payan, Cecilia Garlanda, P Nigel Leigh

EBioMedicine· September 2020

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Reply to: Early white matter changes on diffusion tensor imaging in amyotrophic lateral sclerosis.
Matt C Gabel, Rebecca J Broad, Alexandra L Young, Sharon Abrahams, Mark E Bastin, P Nigel Leigh

Ann Clin Transl Neurol· July 2020

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Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis.
Greig Joilin, Elizabeth Gray, Alexander G Thompson, Yoana Bobeva, Kevin Talbot, P Nigel Leigh

Brain Commun· June 2020

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Evolution of white matter damage in amyotrophic lateral sclerosis.
Matt C Gabel, Rebecca J Broad, Alexandra L Young, Sharon Abrahams, Mark E Bastin, P Nigel Leigh

Ann Clin Transl Neurol· May 2020

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Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
Edwin Jabbari, Negin Holland, Viorica Chelban, P Simon Jones, Ruth Lamb, P Nigel Leigh

JAMA Neurol· March 2020

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Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis.
Michael Swash, David Burke, Martin R Turner, Julian Grosskreutz, P Nigel Leigh

J Neurol Neurosurg Psychiatry· March 2020

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Corrigendum: An Overview of MicroRNAs as Biomarkers of ALS.
Greig Joilin, P Nigel Leigh, Sarah F Newbury, Majid Hafezparast

Front Neurol· October 2019

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