Publications by authors named "Timothy Tree"

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Stratifying IL-2 therapy in ALS: integrating biomarkers - Authors' reply.
Gilbert Bensimon, P Nigel Leigh, Timothy Tree

Lancet· November 2025

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Subcutaneous Abatacept in New Onset Type 1 Diabetes: Clinical and Immunological Effects.
Samuel T Jerram, Jennie H M Yang, Evangelia Williams, Clara Domingo-Vila, Yuk-Fun Liu, Timothy Tree

Diabetes Metab Res Rev· September 2025

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Minimum effective low dose of antithymocyte globulin in people aged 5-25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial.
Chantal Mathieu, Julie Wych, A Emile J Hendriks, Lisa Van Ryckeghem, Timothy Tree

Lancet· September 2025

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Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays.
Clara Domingo-Vila, Evangelia D Williams, Megan E Smithmyer, Basilin Benson, Lauric A Ferrat, Timothy I M Tree

Front Immunol· August 2025

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Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial.
Gilbert Bensimon, P Nigel Leigh, Timothy Tree, Andrea Malaspina, Christine Am Payan

Lancet· May 2025

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Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance.
Helen Stark, Quan Yao Ho, Amy Cross, Alessandro Alessandrini, Alice Bertaina, Timothy Tree

Transplantation· April 2025

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Anti-viral action against type 1 diabetes autoimmunity: The GPPAD-AVAnT1A study protocol.
Sandra Hummel, Alexandra Käßl, Stefanie Arnolds, Peter Achenbach, Reinhard Berner, Timothy Tree

Contemp Clin Trials Commun· April 2025

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Clonal driver neoantigen loss under EGFR TKI and immune selection pressures.
Maise Al Bakir, James L Reading, Samuel Gamble, Rachel Rosenthal, Imran Uddin, Timothy I M Tree

Nature· March 2025

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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
Masato Ogishi, Koji Kitaoka, Kim L Good-Jacobson, Darawan Rinchai, Baihao Zhang, Timothy I Tree

Immunity· December 2024

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Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial.
Danijela Tatovic, Ashish Marwaha, Peter Taylor, Stephanie J Hanna, Kym Carter, Timothy I M Tree

Nat Med· September 2024

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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Timothy I Tree

J Exp Med· June 2024

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Pharmacometabolomics applied to low-dose interleukin-2 treatment in amyotrophic lateral sclerosis.
Hugo Alarcan, Clément Bruno, Patrick Emond, Cédric Raoul, Patrick Vourc'h, Timothy Tree

Ann N Y Acad Sci· June 2024

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A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes.
Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Timothy Tree

Cell Rep Med· June 2024

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Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis.
Hania Arain, Tina Patel, Nicoleta Mureanu, Athina Efthymiou, Giovanna Lombardi, Timothy Tree

Front Immunol· December 2023

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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.
Stephanie J Hanna, Terri C Thayer, Emma J S Robinson, Ngoc-Nga Vinh, Nigel Williams, Timothy I M Tree

Front Immunol· November 2023

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Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials.
Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams, Timothy I M Tree

Front Immunol· June 2023

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IL-2-based approaches to Treg enhancement.
Ffion Harris, Yoana Arroyo Berdugo, Timothy Tree

Clin Exp Immunol· March 2023

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Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis.
Ozlem Yildiz, Johannes Schroth, Timothy Tree, Martin R Turner, Pamela J Shaw

Neurol Neuroimmunol Neuroinflamm· January 2023

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Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19.
Marc F Österdahl, Eleni Christakou, Deborah Hart, Ffion Harris, Yasaman Shahrabi, Timothy Tree

J Med Virol· November 2022

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Low-dose IL-2 reduces IL-21 T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Timothy I M Tree

Nat Commun· November 2022

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Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer.
Duncan R McKenzie, Rosalind Graham, Thomas Lechmere, Clara Domingo-Vila, Thanussuyah Alaguthurai, Timothy Tree

Cancer Res Commun· November 2022

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The Impact of Immune-Modifying Treatments for Skin Diseases on the Immune Response to COVID-19 Vaccines: a Narrative Review.
Su-Yi Liew, Timothy Tree, Catherine H Smith, Satveer K Mahil

Curr Dermatol Rep· October 2022

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INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.
David B Dunger, Sylvaine F A Bruggraber, Adrian P Mander, M Loredana Marcovecchio, Timothy Tree

Trials· May 2022

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The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis.
Ozlem Yildiz, Johannes Schroth, Vittoria Lombardi, Valentina Pucino, Yoana Bobeva, Timothy Tree

Int J Mol Sci· March 2022

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