Publications by authors named "Timothy I Tree"

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Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
Masato Ogishi, Koji Kitaoka, Kim L Good-Jacobson, Darawan Rinchai, Baihao Zhang, Timothy I Tree

Immunity· December 2024

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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Timothy I Tree

J Exp Med· June 2024

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Generation of human islet-specific regulatory T cells by TCR gene transfer.
Caroline M Hull, Lauren E Nickolay, Megan Estorninho, Max W Richardson, James L Riley, Timothy I M Tree

J Autoimmun· May 2017

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Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes.
Jennie H M Yang, Antony J Cutler, Ricardo C Ferreira, James L Reading, Nicholas J Cooper, Timothy I M Tree

Diabetes· November 2015

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Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.
Gavin M Mason, Katie Lowe, Rossella Melchiotti, Richard Ellis, Emanuele de Rinaldis, Timothy I M Tree

J Immunol· September 2015

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Immune modulation in humans: implications for type 1 diabetes mellitus.
Bart O Roep, Timothy I M Tree

Nat Rev Endocrinol· April 2014

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Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.
James L Reading, Jennie H M Yang, Shereen Sabbah, Ania Skowera, Robin R Knight, Timothy I M Tree

J Immunol· May 2013

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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.
Marcin L Pekalski, Ricardo C Ferreira, Richard M R Coulson, Antony J Cutler, Hui Guo, Timothy I M Tree

J Immunol· March 2013

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Mesenchymal stromal cells as a means of controlling pathological T-cell responses in allogeneic islet transplantation.
James L Reading, Shereen Sabbah, Sarah Busch, Timothy I M Tree

Curr Opin Organ Transplant· February 2013

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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.
Garima Garg, Jennifer R Tyler, Jennie H M Yang, Antony J Cutler, Kate Downes, Timothy I M Tree

J Immunol· May 2012

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Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression.
Timothy I M Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif

Diabetes· June 2010

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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Ania Skowera, Richard J Ellis, Ruben Varela-Calviño, Sefina Arif, Guo Cai Huang, Timothy I M Tree

J Clin Invest· October 2008

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Reconstruction of a pathway of antigen processing and class II MHC peptide capture.
Catherine X Moss, Timothy I Tree, Colin Watts

EMBO J· April 2007

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A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop.
Timothy I M Tree, Bart O Roep, Mark Peakman

Ann N Y Acad Sci· October 2006

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HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee.
Gabrielle G M Pinkse, Christian Boitard, Timothy I M Tree, Mark Peakman, Bart O Roep

Ann N Y Acad Sci· October 2006

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HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.
Richard J Ellis, Ruben Varela-Calvino, Timothy I M Tree, Mark Peakman

Immunology· November 2005

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Shelley Lindley, Colin M Dayan, Amanda Bishop, Bart O Roep, Mark Peakman, Timothy I M Tree

Diabetes· January 2005

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Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media.
Timothy I M Tree, Bart O Roep, Mark Peakman

Ann N Y Acad Sci· December 2004

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HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.
Timothy I M Tree, Gaby Duinkerken, Sabine Willemen, René R P de Vries, Bart O Roep

Diabetes· July 2004

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Autoreactive T cells in human type 1 diabetes.
Timothy I M Tree, Mark Peakman

Endocrinol Metab Clin North Am· March 2004

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
Sefina Arif, Timothy I Tree, Thomas P Astill, Jennifer M Tremble, Amanda J Bishop

J Clin Invest· February 2004

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Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells.
James E Greening, Timothy I M Tree, Karolena T Kotowicz, Astrid G van Halteren, Bart O Roep

Diabetes· March 2003

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