Publications by authors named "Noah G Shuart"

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The contribution of Na1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na1.6 gain-of-function (GOF) mouse seizure control.
James P Johnson, Thilo Focken, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Noah Gregory Shuart

Br J Pharmacol· October 2024

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Molecular Pharmacology of Selective Na1.6 and Dual Na1.6/Na1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.
Samuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, Wenlei Ye, R Ryley Parrish

ACS Chem Neurosci· March 2024

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Expanding the genotype-phenotype spectrum in SCN8A-related disorders.
Malavika Hebbar, Nawaf Al-Taweel, Inderpal Gill, Cyrus Boelman, Richard A Dean, Noah Gregory Shuart

BMC Neurol· January 2024

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Expanding the genotype-phenotype spectrum in SCN8A-related disorders.
Malavika Hebbar, Nawaf Al-Taweel, Inderpal Gill, Cyrus Boelman, Richard A Dean, Noah Gregory Shuart

Res Sq· August 2023

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NBI-921352, a first-in-class, Na1.6 selective, sodium channel inhibitor that prevents seizures in gain-of-function mice, and wild-type mice and rats.
J P Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Noah Gregory Shuart

Elife· March 2022

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Inhibitory effects of cannabidiol on voltage-dependent sodium currents.
Mohammad-Reza Ghovanloo, Noah Gregory Shuart, Janette Mezeyova, Richard A Dean, Peter C Ruben

J Biol Chem· October 2018

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Selective Na1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.
Girish Bankar, Samuel J Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Noah G Shuart

Cell Rep· September 2018

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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa1.7 Inhibitors for the Treatment of Pain.
Thilo Focken, Sultan Chowdhury, Alla Zenova, Michael E Grimwood, Christine Chabot, Noah G Shuart

J Med Chem· June 2018

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Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.
Noah G Shuart, Yoni Haitin, Stacey S Camp, Kevin D Black, William N Zagotta

Nat Commun· August 2011

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Synaptosomes as a platform for loading nanoparticles into synaptic vesicles.
Kristi L Budzinski, Allyson E Sgro, Bryant S Fujimoto, Jennifer C Gadd, Noah G Shuart

ACS Chem Neurosci· May 2011

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