Publications by authors named "Norbert Handler"

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Mechanochemical Degradation of Active Pharmaceutical Ingredients (APIs): A Simple Tool for the Prediction of Drug Stability.
Ulrike Holzgrabe, Helmut Buschmann, Norbert Handler, Mostafa M Amer, Renè Hommelsheim

Chimia (Aarau)· September 2025

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Prediction of Degradation Profiles for Various Sartans under Solvent-Free Mechanochemical Conditions.
Mostafa M Amer, Laura Backer, Helmut Buschmann, Norbert Handler, Oliver Scherf-Clavel

Anal Chem· August 2024

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The quality of drugs and drug products - Always guaranteed?
Helmut Buschmann, Norbert Handler, Ulrike Holzgrabe

J Pharm Biomed Anal· February 2024

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Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability.
Everaldo F Krake, Laura Backer, Benjamin Andres, Wolfgang Baumann, Norbert Handler

ACS Cent Sci· June 2023

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Ball milling - a new concept for predicting degradation profiles in active pharmaceutical ingredients.
Reinhard P Kaiser, Everaldo F Krake, Laura Backer, Jonas Urlaub, Wolfgang Baumann, Norbert Handler

Chem Commun (Camb)· November 2021

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A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages.
Burkhard Kloesch, Silvia Loebsch, Jenny Breitenbach, Katrin Goldhahn, Norbert Handler

Nat Prod Commun· October 2016

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New approaches to treating pain.
Andrea Wolkerstorfer, Norbert Handler, Helmut Buschmann

Bioorg Med Chem Lett· February 2016

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Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells.
Katrin Goldhahn, Norbert Handler, Silvia Loebsch, Klaus Schmetterer, Guenter Steiner

Anticancer Res· February 2016

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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.
Franziska Bollmann, Julia Art, Jenny Henke, Katharina Schrick, Verena Besche, Norbert Handler

Nucleic Acids Res· November 2014

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Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.
Astrid Bernhaus, Maria Ozsvar-Kozma, Philipp Saiko, Margit Jaschke, Andreas Lackner, Norbert Handler

Invest New Drugs· October 2009

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Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR.
Gerda Brunhofer, Norbert Handler, Klaus Leisser, Christian R Studenik, Thomas Erker

Bioorg Med Chem· June 2008

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Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity.
Philipp Saiko, Michael Pemberger, Zsuzsanna Horvath, Ivo Savinc, Michael Grusch, Norbert Handler

Oncol Rep· June 2008

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Synthesis and biological activity of thienodiltiazem in isolated heart muscle preparations of guinea pigs.
Norbert Handler, Thomas Erker, Rosa Lemmens-Gruber, Christian R Studenik

Arzneimittelforschung· May 2008

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Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds.
Yvonne Bader, Sibylle Madlener, Stephan Strasser, Susanne Maier, Philipp Saiko, Norbert Handler

Oncol Rep· March 2008

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No evidence for modulation of endothelial nitric oxide synthase by the olive oil polyphenol hydroxytyrosol in human endothelial cells.
Christoph A Schmitt, Norbert Handler, Elke H Heiss, Thomas Erker, Verena M Dirsch

Atherosclerosis· November 2007

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N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine.
Philipp Saiko, Maria Ozsvar-Kozma, Astrid Bernhaus, Margit Jaschke, Geraldine Graser, Norbert Handler

Int J Oncol· November 2007

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Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines.
Zsuzsanna Horvath, Sybille Marihart-Fazekas, Philipp Saiko, Michael Grusch, Mehmet Ozsüy, Norbert Handler

Anticancer Res· November 2007

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'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.
Norbert Handler, Gerda Brunhofer, Christian Studenik, Klaus Leisser, Walter Jaeger

Bioorg Med Chem· September 2007

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Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors.
Norbert Handler, Walter Jaeger, Helmut Puschacher, Klaus Leisser, Thomas Erker

Chem Pharm Bull (Tokyo)· January 2007

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Cytotoxic and biochemical effects of 3,3',4,4',5,5'-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells.
Zsuzsanna Horvath, Marek Murias, Philipp Saiko, Thomas Erker, Norbert Handler

Exp Hematol· October 2006

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Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.
Zdenka Ovesná, Katarína Kozics, Yvonne Bader, Philipp Saiko, Norbert Handler

Oncol Rep· September 2006

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Studies on the chemistry of thienoanellated O,N- and S,N-containing heterocycles. Part 30: synthesis and pharmacological properties of thieno[2,3-b][1,4]thiazines with potential vasopressin receptor antagonistic activity.
Maria E Galanski, Thomas Erker, Norbert Handler, Rosa Lemmens-Gruber, Majidreza Kamyar

Bioorg Med Chem· February 2006

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Cyclooxygenase-1 and cyclooxygenase-2 inhibition of novel 1,2-disubstituted imidazoles.
Norbert Handler, Walter Jaeger, Bea Kuen-Krismer, Thomas Erker

Arch Pharm (Weinheim)· December 2005

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Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship.
Marek Murias, Walter Jäger, Norbert Handler, Thomas Erker, Zsuzsanna Horvath

Biochem Pharmacol· March 2005

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Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.
Marek Murias, Norbert Handler, Thomas Erker, Karin Pleban, Gerhard Ecker

Bioorg Med Chem· November 2004

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