Publications by authors named "Noriko Handa"

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Intramyocardial Transplantation of Human iPS Cell-Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals.
Shinji Kawaguchi, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama, Noriko Handa

JACC Basic Transl Sci· March 2021

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Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method.
Daisuke Takaya, Hideaki Niwa, Junko Mikuni, Kana Nakamura, Noriko Handa

J Mol Graph Model· September 2020

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Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.
Hideaki Niwa, Shin Sato, Noriko Handa, Toru Sengoku, Takashi Umehara

ChemMedChem· May 2020

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Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
Tomohiro Sato, Katsuhiko Sekimata, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Noriko Handa

ACS Omega· May 2020

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Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Noriko Handa

Chem Pharm Bull (Tokyo)· April 2019

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Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell‒derived cardiomyocytes.
Ryota Tabei, Shinji Kawaguchi, Hideaki Kanazawa, Shugo Tohyama, Akinori Hirano, Noriko Handa

J Heart Lung Transplant· February 2019

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Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.
Yasushi Takemoto, Akihiro Ito, Hideaki Niwa, Mutsumi Okamura, Takashi Fujiwara, Noriko Handa

J Med Chem· April 2016

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Crystal structures of the S6K1 kinase domain in complexes with inhibitors.
Hideaki Niwa, Junko Mikuni, Shunta Sasaki, Yuri Tomabechi, Keiko Honda, Noriko Handa

J Struct Funct Genomics· September 2014

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Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Lorien J Parker, Shigenao Taruya, Keiko Tsuganezawa, Naoko Ogawa, Junko Mikuni, Noriko Handa

Acta Crystallogr D Biol Crystallogr· February 2014

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Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).
Shinji Mori, Yuta Tezuka, Akihiko Arakawa, Noriko Handa, Mikako Shirouzu

Biochem Biophys Res Commun· June 2013

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Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
Hideaki Niwa, Noriko Handa, Yuri Tomabechi, Keiko Honda, Mitsutoshi Toyama

Acta Crystallogr D Biol Crystallogr· April 2013

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A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Yoriko Saito, Hitomi Yuki, Mitsuo Kuratani, Yoshinobu Hashizume, Shinsuke Takagi, Noriko Handa

Sci Transl Med· April 2013

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Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor.
Lorien J Parker, Hisami Watanabe, Keiko Tsuganezawa, Yuri Tomabechi, Noriko Handa

Acta Crystallogr Sect F Struct Biol Cryst Commun· August 2012

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A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.
Keiko Tsuganezawa, Hisami Watanabe, Lorien Parker, Hitomi Yuki, Shigenao Taruya, Noriko Handa

J Mol Biol· March 2012

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Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.
Ella Czarina Morishita, Kazutaka Murayama, Miyuki Kato-Murayama, Yoshiko Ishizuka-Katsura, Yuri Tomabechi, Noriko Handa

Structure· October 2011

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ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.
Makoto Nagano, Daisuke Hoshino, Seizo Koshiba, Takuya Shuo, Naohiko Koshikawa, Noriko Handa

J Biol Chem· September 2011

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Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Akihiko Arakawa, Noriko Handa, Mikako Shirouzu, Shigeyuki Yokoyama

Protein Sci· August 2011

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Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
Noriko Handa, Tetsuo Takagi, Shinya Saijo, Seiichiro Kishishita, Daisuke Takaya

Acta Crystallogr D Biol Crystallogr· May 2011

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An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.
Noriko Handa, Takeshi Yamada, Reiko Tanaka

Phytochemistry· October 2010

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The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.
Akihiko Arakawa, Noriko Handa, Noboru Ohsawa, Meiri Shida, Takanori Kigawa

Structure· March 2010

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Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP.
Noriko Handa, Eiichi Mizohata, Seiichiro Kishishita, Mitsutoshi Toyama, Satoshi Morita

J Biol Chem· July 2008

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Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form.
Noriko Handa, Seiichiro Kishishita, Satoshi Morita, Ryogo Akasaka, Zhongmin Jin

Acta Crystallogr D Biol Crystallogr· December 2007

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Structure of the UNC5H2 death domain.
Noriko Handa, Mutsuko Kukimoto-Niino, Ryogo Akasaka, Kazutaka Murayama, Takaho Terada

Acta Crystallogr D Biol Crystallogr· December 2006

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The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain.
Noriko Handa, Mutsuko Kukimoto-Niino, Ryogo Akasaka, Seiichiro Kishishita, Kazutaka Murayama

J Mol Biol· October 2006

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Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8.
Noriko Handa, Takaho Terada, Yukiko Doi-Katayama, Hiroshi Hirota, Jeremy R H Tame

Protein Sci· April 2005

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